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E Bourstyn

Publications and source records attributed to E Bourstyn.

29 records · Page 2Linked to original sources
PubMed1987

Anorexia in oesophageal carcinoma.

The influence of anorexia on nutritional status and tumour resectability was prospectively assessed in 50 patients with oesophageal carcinoma and severe dysphagia. Among the 21 patients in whom anorexia was present, objective measurement of clinical status demonstrated that malnutrition was present in 13 (62%) and resection of the tumour was possible only in five (24%). On the contrary, among the 29 patients without anorexia, malnutrition was only present in five (17%) and resection of the tumour was possible in 24 (82%). We conclude that anorexia is a main determinant of malnutrition and that it is related to the tumour development independently of dysphagia. In patients with oesophageal carcinoma, the clinical assessment of anorexia must be used for evaluating nutritional status before surgery. The presence of anorexia suggests a widespread tumour or a disseminated cancer and it might explain the poor nutritional effects of palliative intubation in non resectable tumour.

Adult↗
PubMed1987

Splenectomy performed upon thirty-seven patients with hairy cell leukemia.

Thirty-seven patients with hairy cell leukemia underwent splenectomy. The postoperative course was uneventful for 34 patients. Improvement of peripheral cytopenia was obtained in the majority of patients. Survival time of patients who underwent splenectomy was significantly longer than for patients who did not undergo this procedure. Splenectomy is a habitually effective form of treatment for hairy cell leukemia, although not completely free of risks.

Adult↗
PubMed1986

Results of portal systemic shunts in Budd-Chiari syndrome.

Nine patients with Budd-Chiari syndrome (BCS) were treated by a portal systemic shunt. One had thrombosis of the superior mesenteric vein (SMV) and another had complete obstruction of the retrohepatic inferior vena cava (IVC). All other patients had a marked stenosis of the retrohepatic IVC with caval pressure ranging from 12 to 24 mmHg (mean: 17 mmHg). Seven patients had an interposition mesocaval shunt using an autologous jugular vein. The patient with a thrombosed SMV had a portoatrial shunt. The patient with an obstructed IVC had a cavoatrial shunt after an erroneous portacaval shunt had failed to relieve ascites. There were no operative deaths and no major postoperative complications. One patient died 19 months after operation of acute leukemia complicating polycythemia rubra vera. All other patients were alive and well 8 months to 6 years after operation. None of them had encephalopathy. These results suggest several comments: Portal systemic shunts are a good treatment for BCS and have a low operative risk. The mesocaval shunt is an efficient procedure, even when there is stenosis of the IVC with high caval pressure; shunts to the right atrium should be performed only in the case of complete obstruction or inaccessibility of the IVC. The long-term prognosis is excellent, except in patients with potential malignancies. Therefore, portal systemic shunts should be indicated early in patients with symptomatic BCS.

Adolescent↗
PubMed1984

[Results of portasystemic shunts in the treatment of the Budd-Chiari syndrome].

Seven patients (6 women and 1 man) with a Budd-Chiari syndrome were treated by a portal systemic shunt (6 mesocaval and 1 portoatrial shunts). Budd-Chiari syndrome occurred after treatment by estrogen-progestational drugs in 3 cases and following delivery in one. It was due to a myeloproliferative syndrome in 2 cases and to narrowing of the ostium of the hepatic veins in one. All patients had ascites before operation and 5 had an increased serum activity of transaminases. One patient was operated in emergency for progressive massive liver cytolysis. There was no operative mortality. In all patients ascites cleared after operation and transaminases returned to normal values. There was no chronic encephalopathy. Six patients are alive and well with a follow-up of 5 to 66 months. One patient died of acute myeloblastic leukemia 19 months after mesocaval shunt. A liver biopsy was obtained in 2 patients 18 months and 2 years after operation. Hemorrhagic necrosis and sinusoidal dilatation had disappeared and there was annular fibrosis. These results suggest that portal-systemic shunting is a good treatment of the Budd-Chiari syndrome. Since the natural history of this syndrome is still poorly known, a surgical shunt should be rapidly decided upon.

Adult↗
PubMed1983

Surgical implications of malnutrition and immunodeficiency in patients with carcinoma of the oesophagus.

A nutritional and immunological assessment was respectively performed in 75 patients with squamous cell carcinoma of the oesophagus. Abnormal nutritional and/or immunological values were present in 37 patients (50 per cent) and absent in 38. The tumour was resectable in 27 patients (71 per cent) with normal values and only in 11 among the 37 (29 per cent) with abnormal values (P less than 0.001). Complications after resection including death, pneumonia and anastomotic failure were not significantly different in the two groups of patients except for anastomotic failure. This observation suggests that reduction of surgical complications by preoperative nutritional therapy might be expected only in few patients with oesophageal carcinoma.

Adult↗
PubMedDate not supplied

Illegitimate villin transcripts in normal bone marrow precludes detection of colon cancer micrometastases.

Villin is a specific marker for normal and tumoral colon tissue. We have developed a highly sensitive assay using reverse transcription (RT) and real-time PCR to detect villin transcripts. The sensitivity of detection is one colon cancer cell. However, high levels of illegitimate villin transcripts were observed in normal bone marrow, precluding the use of villin RT-PCR for routine detection of colon cancer cells in bone marrow of patients with colon cancer.

Biomarkers↗