Pseudolipomatosis cutis.
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Acrodermatitis↗
Biomedical subjects
E Brehmer-Andersson
Publications and source records attributed to E Brehmer-Andersson.
Acrodermatitis chronica atrophicans: histopathologic findings and clinical correlations in 111 cases.
We studied 111 consecutive, untreated and serologically confirmed patients with acrodermatitis chronica atrophicans. Emphasis was on the histopathologic patterns of erythematous and fibrous lesions, and on an assay used to correlate histopathologic findings with such clinical features as fibrous nodules, ulnar bands and the pain reaction allodynia. There was a significant correlation between allodynia and signs of marked inflammation, but not between allodynia and neural and perineural cell infiltrates or fibrosis. Moreover, there was no significant correlation between serum IgG titers to Borrelia and the density of inflammatory cell infiltrates or the proportion of plasma cells in tissue. Histopathologic examination did not reveal any important differences between fibrous nodules, ulnar bands and sclerodermatous lesions. The histopathologic pattern is not diagnostic per se, but characteristic enough to alert the experienced pathologist.
Acrodermatitis↗
Oral hairy leukoplakia: pathogenetic aspects and significance of the lesion.
Oral hairy leukoplakia in HIV-seropositive persons is considered as a highly serious sign and places the patient in the AIDS-related complex group according to the classification recommended by the Centers for Disease Control. Epstein-Barr virus (EBV) is thought to be the cause. Based on the investigation of 14 of our own cases and a review of the literature, we conclude that so called hairy leukoplakia does not have a specific histopathologic pattern. Identical lesions can be caused by fungus infection, or biting and other kinds of mechanical irritation. Both fungal infection and EBV infection have been proven in a high percentage of the lesions. However, EBV has been found also in apparently normal oral mucosa. This questions the assumption that the virus is the cause of the lesions. In our investigation the presence of "hairy leukoplakia" did not reflect the clinical status of the patient. The best indicator of the clinical status was the T-lymphocyte subset CD4+ number in the peripheral blood. It appears that low CD4+ counts, candidiasis and the presence of replicating EBV in the epithelial cells are parallel markers of increasing immunodeficiency.
Adult↗
Isoenzymes of alkaline phosphatases in seminomas. An immunohistochemical and biochemical study.
Placental alkaline phosphatase (the PLAP-like isoenzyme) and liver alkaline phosphatase (LAP) were demonstrated immunohistochemically by use of monoclonal antibodies in the tumor cells of twelve seminomas and one seminoma metastasis. Intestinal alkaline phosphatase (IAP) was not found. The PLAP-like and LAP enzymes showed high catalytic activities compared to normal testis. This is the first occasion that LAP has been demonstrated by immunochemistry in seminoma cells. The results suggest that demonstration of these tumor enzymes may be useful markers for seminomas in histopathological specimens.
Alkaline Phosphatase↗
The exanthema of acute (primary) HIV infection. Identification of a characteristic histopathological picture?
A male homosexual presented with a skin rash, pharyngitis, fever and lymphadenopathy. The clinical symptoms were suggestive of an acute primary HIV infection. The diagnosis was confirmed serologically. We describe here the clinical and histopathological picture of the exanthema. Biopsy from a papular skin lesion revealed a possibly characteristic pattern.
Acquired Immunodeficiency Syndrome↗
Occupational dermatoses from colour developing agents. Clinical and histopathological observations.
Exposure to colour developing agents that are derivatives of p-phenylenediamine, e.g. CD-2 and CD-3, are known to cause lichenoid lesions and allergic contact dermatitis. This study describes the clinical picture, course and patch test results in 24 patients with occupational skin disease caused by colour developing agents. Biopsies for histopathology of the occupationally-induced lesions and/or patch test reactions were obtained in 14 cases. The skin lesions cleared rapidly after exposure to colour developers had ceased. Sixteen patients had to leave their exposed work due to the skin disease. Contact allergy to colour developing agents was found in 23 cases. The clinical and histopathological findings showed that lichen planus and lichen planus-like lesions were common among the dermatoses caused by colour developers. It was not possible to provoke lichenoid lesions by patch testing. The histopathology of the patch test reactions showed dermatitis.
Adolescent↗
Patterns of seminoma tissue markers and deletions.
Seminomas and control tissues were analyzed for several tumor markers. Very high levels of placental alkaline phosphatase (PLAP)-like enzyme levels were found in all 18 seminomas studied. The majority of the seminomas were of phenotype I, thus differing from palcental PLAP. The mean amount of enzyme protein as measured by monoclonal antibodies, was 100 times higher than in non-malignant tissues and 10 times lower than in placental tissue. The specific enzymatic activity in seminomas was about half of that observed in placenta. Similarly, the specific activity of PLAP-like enzymes in sera of patients with seminoma was only about half of that found in pregnancy sera. HCG was strongly elevated in 3 seminomas, but not obviously related to PLAP. Thirteen of the 17 pure seminomas had HCG over 100 IU/g, which was not seen in normal testes. Liver alkaline phosphatase (LAP) and intestinal alkaline phosphatase (IAP) were high in seminomatous tissues, the mean increases being 60-fold and 20-fold, respectively. The highest IAP levels were found in 2 yolk-sac tumors. Ferritin was moderately elevated in seminomas, but high in several control tissues. Carcinoembryonic antigen (CEA) was not elevated and alpha-fetoprotein (AFP) was not detected at all in pure seminomas. A decrease in carbohydrate antigen 50 (CA-50) content was noted in seminomas as compared to normal testes, yolk-sac tumors and choriocarcinomas. Defects in tumor-related enzymes may account for increase of PLAP and decrease of CA-50.
Alkaline Phosphatase↗
Therapeutic ureteral occlusion in advanced pelvic malignant tumors.
A technique for ureteral occlusion, combining insertion of nylon plugs with injection of polidocanol, is described. The method was used in 15 patients with vesicovaginal fistulas after operation and irradiation for advanced gynecological malignancy, or with severe malfunction and fibrosis of the bladder after radiotherapy for bladder carcinoma. The urinary leakage ceased in 11 patients, was greatly diminished in 2 and was unchanged in 2. Migration of plugs to the renal pelvis was the most serious complication and may have been the cause of pyelonephritis in 1 case. The technique is recommended for patients with a short life expectancy and uncontrolled, distressing leakage of urine.
Adult↗
Acrodermatitis chronica atrophicans--a spirochetosis. Clinical and histopathological picture based on 32 patients; course and relationship to erythema chronicum migrans Afzelius.
The recent discovery that spirochetes transmitted by the tick Ixodes ricinus are involved in the etiology of erythema chronicum migrans Afzelius (ECMA), Bannwarth's syndrome, and acrodermatitis chronica atrophicans (ACA) has thrown new light upon these disorders. Thirty-two patients showing clinical and serological evidence of ACA were investigated. Histologically, constant findings in active ACA lesions were telangiectases and a lymphocytic infiltrate with a moderate to rich admixture of plasma cells. Clinically, besides ACA lesions, lichen sclerosus et atrophicus (LSA)-like lesions were found in five patients. Four of these patients displayed a histopathological picture compatible with LSA. These findings suggest a relationship between ACA and LSA. In six patients spontaneous healing of ECMA was followed by ACA lesions after a latency period of 1-8 years. Six patients reported histories of cranial nerve involvement. Radiography revealed subluxation of joints in hands or feet in six patients, and periosteal thickening in another three patients. The results indicate that ACA may be a late manifestation of infection with the same spirochete that causes ECMA and Bannwarth's syndrome. If untreated, the infection may continue for many years and result in irreversible degenerative lesions.
Acrodermatitis↗
The histopathogenesis of the flame figure in Wells' syndrome based on five cases.
Characteristics of Wells' syndrome are recurrent episodes of edema and erythema of sudden onset, often covering large areas of the skin. Microscopy shows marked eosinophilia and the presence of so-called flame figures. The flame figures have been considered to be either secondary to aggregates of expelled eosinophilic granules and disintergrating eosinophils, or foci of necrobiotic collagen. Our study indicates that the flame figure is secondary to disintegration of eosinophils and consists of aggregates of eosinophilic granules and nuclear fragments and not of necrobiotic collagen. We consider Wells' syndrome to be a distinctive clinical and histological reaction, which can be triggered by many different, mostly unknown factors.
Adolescent↗
Extensive hemangiomatosis of the extremities with the same histopathological pattern as the early lesion of Kaposi's sarcoma.
For 13 years a 28-year-old man had on his hands and feet bluish red patches, which had slowly progressed in size. Biopsy specimens exhibited an abnormal vascular pattern similar to that seen in early lesions of Kaposi's sarcoma. Skeletal radiographs of the hands and feet showed lesions indicating hemangiomatosis.
Adult↗
Hemorrhagic infarctions of testis due to intimal fibroplasia of spermatic artery.
Two cases of hemorrhagic infarctions of the testis are presented. The infarctions were due to intimal fibroplasia of the branches of the spermatic artery; to our knowledge, a condition described only in the kidney. The differences between intimal fibroplasia and the lesions of polyarteritis nodosa and thromboangiitis obliterans are discussed.
Adult↗
Eutopic expression of placental-like alkaline phosphatase in testicular tumors.
Very high levels of placental-like alkaline phosphatases (PLAP-like enzymes) were observed in tissues from 13 typical seminomas. Four tumors with seminoma components contained these enzymes to varying degrees, and other testicular tumors had them in smaller or non-detectable amounts. Analysis using monoclonal antibodies produced against the common placental alkaline phosphatase (PLAP) phenotypes and enzyme inhibition studies with amino acids and peptides showed the PLAP-like enzymes present in seminoma to be similar to those PLAP-like enzymes which are expressed in lower amounts in two embryonal carcinomas and in trace amounts in normal testicular tissue. These similarities suggest that the increased expression of PLAP-like enzymes in seminomas results from enhanced eutopic expression of enzymes found in normal testis.
Alkaline Phosphatase↗
Cytologic diagnosis of renal cell carcinoma.
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Adenocarcinoma↗
Lymphomatoid papulosis. A concept which encompasses more than one disease process.
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Adult↗
Detection of different DNA stem cell lines in a case of human bladder carcinoma.
An unusual case of bladder carcinoma is presented. The cystectomy specimen contained one large tumour with the histological picture of a poorly-moderately well-differentiated squamous cell carcinoma and another small tumour with poorly-differentiated transitional cell carcinoma. Besides, widespread areas of carcinoma in situ were seen. Random biopsies from the bladder and from the tumours were independently examined, histopathologically and by flow-cytofluorometric DNA-analyses. The degree of ploidy was found to be quite different between the two tumours. In areas of carcinoma in situ different aneuploid cll lines were indicated. Altogether five different aneuploid cell lines were found. There was a good correlation between the histopathological assessments and the DNA measurements: Carcinoma in situ corresponding to aneuploidy and various degrees of atypia corresponding to diploidy. In tumour metastases from several organs, only one aneuploid cell line was found. This cell line did not correspond to those found in the tumours.
Aged↗
Suppressor T cells in mycosis fungoides and so-called premycotic eruptions.
The proportions of suppressor T cells (TG) and helper T cells (TM) were determined in 5 patients with Mycosis fungoides (MF), 4 patients with parapsoriasis en plaques/poikiloderma atrophicans vasculare and 3 patients with generalized chronic dermatitis. All the MF patients showed increased proportions of suppressor T cells, whereas the others did not differ from age- and sex-matched healthy controls.
Adult↗
Mycosis fungoides and its relation to Sézary's syndrome, lymphomatoid papulosis, and primary cutaneous Hodgkin's disease. A clinical, histopathologic and cytologic study of fourteen cases and a critical review of the literature.
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Adult↗