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Biomedical subjects

E Briggs

Publications and source records attributed to E Briggs.

10 recordsLinked to original sources

Holt-Oram syndrome with hypoplastic left heart syndrome in an African child.

This report illustrates the rare association of Holt-Oram syndrome with hypoplastic left heart syndrome hitherto unreported in an African child. The above association is highlighted as this child and the only other case reported in a Caucasian were diagnosed post mortem. The need for early cardiovascular and genetic evaluation or simple detailed family history to aid counselling is also emphasised.

Abnormalities, Multiple↗

The effects of adding fluoride compounds to a fluoride-free glass ionomer cement on subsequent fluoride and sodium release.

Studies have shown that ions in a glass ionomer matrix are 1-10% of the amounts present in the original glass. To measure more precisely the release from a cement matrix, known amounts of ions were added to LG30 glass which was fluoride and sodium-free. Cement without additions acted as the control. 1.4-1.6% of each of sodium, calcium and aluminum fluorides were added to three portions of control blend. The sodium and fluoride release into deionised water from five discs of each cements blend was measured for 8 months. This represented complete release for sodium but not for fluoride. Traces of fluoride and sodium in the glass produced low but measurable amounts indicating about a third of the fluoride and substantially all sodium present in LG30 was released. The addition of calcium fluoride had no significant effect on sodium or fluoride release and aluminium fluoride minimal effects. Adding sodium fluoride significantly enhanced release of both ions although fluoride release was less than from a glass containing 5% fluoride. Only small proportions of the additions, 2-5% of the fluoride and 13% of sodium, were released. Sodium and fluoride appeared to be released independently. For LG30 cements additives were poor at supplying extra ions.

Acrylic Resins↗

[Congenital ischemic onychodystrophy (Iso-Kikuchi syndrome) and chronic lupus erythematosus].

We report a patient with nail and bone disorders of the index and middle fingers (Iso and Kikuchi syndrome) associated with chronic discoid lupus erythematosus. Angiographic studies showed filiform arteries of the fingers and slow blood circulation. Since a vascular pathogenic mechanisms is probable, the designation "Congenital ischemic onychodystrophy" seems more suitable. The association with chronic discoid lupus erythematosus has not previously been reported.

Adult↗

Blood pressure in women taking oral contraceptives.

A controlled prospective survey of women taking oestrogen-progestogen oral contraceptives showed increases in mean systolic and diastolic blood pressure of 14.2 mm Hg and 8.5 mm Hg respectively after four years. The largest increases in individual cases were 36 mm Hg systolic and 20 mm Hg diastolic. Blood pressure returned to pretreatment levels within three months after oral contraceptives had been stopped. These changes in blood pressure were unrelated to the progestogenic potencies of the preparations being taken.

Adult↗