[Severe growth retardation: results of a study of fetal blood samples (cordocentesis)].
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Biomedical subjects
Publications and source records attributed to E Brusis.
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Fetal Dopplersonography is a not generally applicable additive method in prenatal care. Its main value is the non-invasive access to the fetal cardiovascular system. Previous studies show a diagnostic gain in sonographically and clinically pathologic pregnancies, mainly those with intrauterine growth retardation. The validity of a general screening of all pregnant women is poor. The examination of fetal physiology, pathophysiology as well as of the influence of drugs on fetuses and pregnant women will profit from Dopplersonography and fetal blood sampling.
The infection with parvovirus B19 during pregnancy causes in 1/3 of the cases an aplastic crisis in the fetus and consecutively generalized fetal hydrops as a result of severe anemia. Some cases of fetal hydrops and intrauterine death are reported. In our two cases, the fetal therapy by intrauterine intravasal transfusion was successful and the children developed normal. The techniques and indications for fetal blood sampling and the method of intrauterine intravasal transfusion are explained.
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The authors report on prenatal ultrasonic diagnosis of foetal liver cysts with a massively thickened and cystic placenta in the twenty-third week of pregnancy. Karyotyping and serological examination of foetal blood samples of the umbilical vein gave normal results. The liver cysts were tapped twice subsequently, because they displaced other foetal abdominal and thoracic organs. In the thirty-fifth week of pregnancy the foetus died due to malnutrition resulting from the changes of the placenta, the origin of which remained unclear.
The authors report on prenatal sonographic diagnosis of a large congenital solitary bronchiogenic pulmonary cyst in the 21st week of pregnancy. The cyst became progressively smaller during the further pregnancy course. After delivery on term the bronchial cyst was removed by surgery. The infant has since developed without any abnormal findings.
The diagnostic accuracy of sonographic screening is demonstrated by the results obtained in 171 pregnant women referred to the Department of Gynaecology of the University of Munich during 1984 for on-target sonography of foetal developmental disturbances. The accuracy was found to be 80%. Examination of pregnant women at risk shows a very low rate of developmental disturbances. The consequences arising from the observed disturbances of development are discussed.
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