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Biomedical subjects

E Bruun

Publications and source records attributed to E Bruun.

At least 37 records · Page 2Linked to original sources
PubMed1988

Dihydrotestosterone measured in core biopsies from prostatic tissues.

Dihydrotestosterone (DHT) levels were measured and related to the content of DNA in 10- to 15-mg tissue samples obtained by punch biopsies from the prostatic gland. The aim of the study was to provide an opportunity to detect the variation of dihydrotestosterone (DHT) in prostatic tissue on endocrine manipulations in phase III studies of metastatic prostatic cancer. DHT was assayed in ranges of 27.9 to 102.9 pg/ml or when related to DNA from 0.57 to 4.00 pg/micrograms DNA by modifying a commercial testosterone/dihydrotestosterone kit. Preliminary clinical results from nine patients with prostatic cancer and eight with benign hyperplasia showed a significantly lower DHT/DNA ratio in prostatic cancer. The predictive value of the histological grading was improved by estimates of the weighted mean nuclear volume. The trend that mean nuclear volume of prostatic cancer exceeded the mean nuclear volume of hyperplasia was clear, and a significantly larger nuclear variation was demonstrated in the malignant specimens. Neither the DHT/DNA ratio nor the mean nuclear volume appears to be sufficient to guide the handling of individual patients, but the described methods enable us by repeated measurements to follow the course of disease and response to treatment.

Aged↗
PubMed1988

Stereological estimates of nuclear volume correlated with clinical stage and progression of prostatic cancer: clinical aspects.

Fifty-one transurethral prostatectomies were reviewed regarding the possible prognostic value of stereological estimation of cell nuclear volume in prostatic cancer. Patients with manifest cancer had a larger nuclear volume than those with incidental cancer, even though the two groups were matched concerning age and histological grade of the cancer. The nuclear volume was larger in patients with incidental cancer than in those with prostatic hyperplasia. Stereological estimation of nuclear volume may be a useful objective supplement to other prognostic parameters in prostatic cancer.

Aged↗
PubMed1987

"TUR syndrome" after transurethral resection of the prostate using suprapubic drainage.

In a retrospective study of 522 consecutive patients who were subjected to transurethral resection of the prostate with suprapubic trocar technique, six patients were suspected of having transurethral prostatic resection syndrome. The majority of the transurethral resections were performed by surgical or urological trainees. Only two patients fulfilled the criterion for TUR syndrome caused by absorption of irrigating fluid and defined as an electrolyte dilution corresponding to a plasma sodium level below 120 mmol/l. In the present paper the symptomatology and treatment of TUR syndrome are outlined with reference to the literature. The trocar technique clearly has minimized the risk of TUR syndrome, which emphasizes the value of the method.

Aged↗
PubMed1987

Incidental versus manifest prostatic carcinoma.

The problem in managing incidental prostatic carcinoma is whether deferred treatment or active therapy should be preferred. Eighty-six consecutive patients with prostatic carcinoma diagnosed at TUR-P during 1979-83 were studied retrospectively. Seventeen of the patients (20%) had incidental prostatic carcinoma. Incidental carcinomas were significantly more well differentiated histologically than manifest carcinomas. The striking difference between incidental and manifest prostatic carcinomas appeared when the clinical course was considered. Only one patient with incidental carcinoma developed symptoms requiring endocrine therapy, against 31 patients with manifest carcinoma (p less than 0.01). It is therefore concluded that the distinction between manifest and incidental prostatic carcinoma is justified and that deferred treatment is sufficient in most patients presenting with incidental prostatic carcinoma at TUR-P.

Aged↗
PubMed1987

Ultrasound in detection of early neoplasia of the testis.

Testicular ultrasound scanning was performed in 192 men with a history of cryptorchidism. The ultrasonic tissue pattern was evaluated and each testis was accordingly given a score on a scale from 1 to 4, 1 representing the normal uniform pattern and 4 being a very irregular pattern. Testicular biopsy of the previously maldescended testicle(s) was carried out in 143 of the scanned men and from two contralateral testicles where the score 4 was given at the ultrasound examination. Two biopsies showed carcinoma-in-situ pattern. Both were found among testes with a very irregular echo pattern. This pattern was found in only 3.2% of all scanned testes.

Adolescent↗
PubMed1987

Testicular biopsy as an outpatient procedure in screening for carcinoma-in-situ: complications and the patient's acceptance.

Testicular biopsy has been performed as a simple outpatient procedure to facilitate screening purposes. The target population was men aged 20-30 years with previous cryptorchidism, and the aim of the study was to discover carcinoma-in-situ. When results from the first 209 consecutive males were assessed, very few and minor complications were encountered. Only three patients needed hospitalization for drainage of pus from the wound. The effects of the procedure as experienced by the patients were evaluated by a questionnaire. 72% of the patients found the method acceptable. The advantages were the patients' minimal absence from their jobs, and the low consumption of resources.

Adult↗
PubMed1987

A randomized trial of postoperative radiotherapy versus observation in stage II and III renal adenocarcinoma. A study by the Copenhagen Renal Cancer Study Group.

Between 1979 and 1984 the Copenhagen Renal Cancer Study Group randomized 72 patients nephrectomized for stages II and III renal adenocarcinoma in a prospective study of postoperative radiotherapy versus observation. Radiotherapy was 50 Gy in 20 fractions to the kidney bed, ipsi- and contralateral lymph nodes. 7/72 were excluded from further analysis because of major protocol violations. 33/65 were in stage II, 32/65 in stage III. Relapse was found in 31/65 = 48% during the follow-up period without any difference between the two groups. 12/27 = 44% had significant complications from stomach, duodenum or liver, median 5 mo., range 1-44 mo. after radiotherapy. In 5/27 = 19% did the postirradiatory complications contribute to the death of the patients. Patients with stage II tumours survived significantly better than those with stage III tumours (p less than 0.05), but no significant differences in survival could be demonstrated between patients randomized to postoperative radiotherapy or observation. It is concluded that postoperative radiotherapy as given in the present study is without any beneficial effect on relapse rate and survival. Moreover, the treatment is associated with an unacceptable complication rate.

Adult↗
PubMed1986

Solitary cyst and clear cell adenocarcinoma of the kidney: report of 2 cases and review of the literature.

We report 2 cases of a solitary simple cyst of the kidney harboring clear cell adenocarcinoma in the wall of the cyst. Cysts of the kidney may be divided into solitary cysts, that is large, unilocular cysts with a thin wall, and multilocular cysts, that is sharply demarcated multilocular epithelial-lined cysts with compression of the adjacent renal parenchyma. There are 4 types of tumor and cyst that occur in the same kidney, and our cases belonged to type 3. Suspicion of malignancy was raised by preoperative cytological examination of the fluid of the cysts. Perioperatively, however, no gross evidence of malignancy was found in either case. Frozen section biopsy in case 1 failed to confirm the diagnosis. The cysts were removed by partial nephrectomy. Patient 1 died within 2 years of widespread metastases. Patient 2 had undergone nephrectomy and was well. Based on the literature and our findings we strongly recommend the surgical approach of partial nephrectomy followed by total nephrectomy when the diagnosis has been confirmed.

Adenocarcinoma↗
PubMed1986

Etiology of urethral stricture following transurethral prostatectomy. A retrospective study.

A retrospective review of 417 transurethral prostatectomies was made regarding the significance of possible etiologies of postoperative urethral stricture. Clinically significant stricture developed in 9% of the patients. Of the studied factors, only indwelling catheter for a short period (1-7 days) within the last preoperative month showed statistically significant correlation with postoperative urethral stricture.

Aged↗
PubMed1985

Absence of testicular steroid sulphatase activity in a boy with recessive X-linked ichthyosis and testicular maldescent.

We present a 14-year-old boy with recessive X-linked ichthyosis in whom only one testis could be found. In this apparently normal testis, a lack of activity of the enzyme steroid sulphatase was demonstrated. Several male patients with recessive X-linked ichthyosis have been reported to have testicular diseases, and it is suggested that this may be related to the absence of testicular steroid sulphatase activity.

Adolescent↗
PubMed1980

Possible antagonists to gastrin in parathyroid adenomas.

The high incidence of gastroduodenal ulcers in patients with hyperparathyroidism has been ascribed to gastric hyperacidity induced by hypercalcaemia. In a clinical study comprising 40 patients with solitary parathyroid adenoma, a negative correlation between serum calcium and spontaneous gastric acid secretion was found. At the same time a positive correlation was found between serum calcium and gastrin. It is concluded that gastric hyperacidity is not part of the syndrome provoked by parathyroid adenomas, and that a mechanism inhibitory to gastrin is active in these patients. It is suggested that the inhibitor could be calcitonin.

Adenoma↗
PubMed1979

Glucagon stimulated plasma cyclic adenosine-3',5'-monophosphate in the differential diagnosis of jaundice.

The amount of plasma cyclic adenosine-3',5'-monophosphate was estimated before and 15 minutes after the intravenous injection of 1 milligram of glucagon in 34 patients with obstructive and in 23 patients with nonobstructive jaundice. After stimulation with glucagon, the median adenosine-3',5'-monophosphate concentration in obstructive jaundice rose fortyfold or more, while in nonobstructive jaundice, the increase was twentyfold or less. The difference was highly significant. The results indicate that this test can be useful in the differential diagnosis of obstructive and nonobstructive jaundice.

Cholestasis↗