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Biomedical subjects

E Businco

Publications and source records attributed to E Businco.

26 records · Page 2Linked to original sources
PubMedDate not supplied

Allergic pathogenesis in chronic bronchitis.

Chronic bronchitis is a disease related to numerous etiologic factors: infections, climate influence, air pollution, cigarette smoking, etc. From a pathogenetic point of view, chronic bronchitis is generally considered as the phlogistic resultant of various irritative conditions, with a characteristic neutrophil component in the phlogistic pattern. Microbic involvement has up to now been considered a very important factor, with consequent wide utilization of antibiotic agents in basic therapy. Considerations of clinical nature induced us to consider unsatisfactory such pathogenetic concepts based on neutrophil phlogosis, while the involvement of an allergic mechanism became more acceptable. In order to solve this problem, we have carried out hitological studies on postmortem material from the respiratory tract of individuals whose death was attributable to chronic bronchitis or to concurrent chronic bronchitis. Results of our study conducted up to now on 60 cases may be summarized as follows: Bronchitis with lymphomonoplasmacytoid phlogosis of immunoallergic type (60%), bronchitis with neutrophil phlogosis of irritative-infective type (20%); bronchitis with mixed allergic-neutrophil phlogosis (20%). Lymphocytes, monocytes and plasma cells are directly involved in allergic tissue reactions, both of immediate and delayed type because they release active substances such as hsitamine, bradyquinine, quinine, etc., which will their multiple pharmacodynamic actions are responsible of various anatomic and functional changes in hypersensitivity. Infiltration of the bronchial mucosa with lymphomonoplasmacytary cells in chronic bronchitis, has a pattern of mixed allergic phlogosis of immediate and delayed type. Prophylaxis and management of chronic bronchitis should therefore be set up on new bases, with the various treatments used for hyperactive pathology.

Adult↗
PubMedDate not supplied

Alternaria allergy: a three-year controlled study in children treated with immunotherapy.

In this prospective controlled study, 39 children with Alternaria-induced asthma and/or rhinitis were followed-up over a 3-year period. Skin tests and RAST were positive to Alternaria tenuis only. All children were treated with specific Alternaria immunotherapy. The long-term results have shown that immunotherapy was successful in 80% of the children given more than 80.000 PNU. By contrast, the outcome of 40 selected controls also followed during the same period who did not receive immunotherapy was almost exactly the opposite. In addition to demonstrating the clinical effectivity of specific Alternaria immunotherapy, the authors stress the relationship between successful results, highest tolerated doses, and larger cumulative dosage, which is irrespective of the duration of the therapy.

Adolescent↗
PubMedDate not supplied

[Coated talcum].

Explore the source record for details and available documents.

Cosmetics↗
PubMedDate not supplied

Evaluation of long-term oral administration of a sustained release theophylline preparation in children with chronic asthma.

Over a one-year-period 23 children with chronic asthma were given an oral sustained-release theophylline preparation in twice-daily doses. Constant therapeutic theophylline levels were maintained in 18 children for the whole period, while in 5 subjects the values were in almost all instances below the therapeutic range. In both groups, however, a good clinical effect from the preparation was observed. Only two children reported nausea and mild abdominal pains, whereas other two children had serum theophylline levels above 20 micrograms/ml with no side effects. It is concluded that oral sustained-release theophylline preparation is effective in providing therapeutic drug concentrations on a 12 hr dose schedule, thus avoiding the risk of lower compliance observed in children given normal theophylline tablets.

Administration, Oral↗
PubMedDate not supplied

Allergy and experimental chronic broncho-pneumopathy.

House dust is a mixture of specific and non-specific stimulating factors. More particularly it contains a wide range of irritating factors, antigens, responsible for the production of immediate and delayed allergic reactions, moulds, microbes, etc. It may therefore be understood that inhalation of house dust induces in the respiratory tract of treated rats various reactive pictures. These pictures are, however, dominated by immuno-allergic reactions. Immuno-allergic reactions are manifested by the dominant increase in plasma cells and lymphocytes. This increase generally occurs in the vicinity of connective tissue macrophages containing numerous dust granules, as if macrophagic digestion formed more active antigens from the dust. Sometimes in the proximity of these plasma cell aggregates, mast cells in the degranulation phase are observed. The release of histamine, serotonin, etc. which occurs with mast cell degranulation produces the intense tissue edema which is observed in these areas. An infiltration with eosinophils is also observed here probably drawn to the site on account of their protective, enzymatic, antihistaminic action. The morphological picture thus indicates the co-existence of two allergic reactive movements: one of the immediate type, the other of the delayed type linked to specific allergens of the mixture of antigens present in house dust. The stimulus of the inhalation of house dust also includes the possible action of microbes, irritants, etc. which produce regressive changes in the tissue, attract polymorphs and stimulate the proliferation of fibroblasts so that more or less wide area of tissue undergo a fibrous transformation. Such changes may be found in the pulmonary parenchyma as well as in the bronchial mucosa. The concordance of these findings with those of chronic bronchitis in man appear sufficiently important to attribute, a predominantly allergic pathogenesis to both pathological conditions. This concept obviously does not exclude other etiopathogenetic factors which under certain environmental or constitutional conditions, may in various degrees be also included in the overall picture of respiratory tissue reactivity.

Allergens↗
PubMedDate not supplied

Results of a milk and/or egg free diet in children with atopic dermatitis.

Food allergy plays an important role in the pathogenesis of atopic dermatitis. Exclusion of eggs and milk from the diet of children during the first few months of life has been proven to significantly reduce the severity of eczema in children aged between 2 and 8 years. We studied the efficacy of exclusion of milk and/or egg from the diet of 59 children with severe atopic dermatitis. A detailed personal and family history was obtained. Total and specific IgE levels were determined on one hand, and intracutaneous tests were evaluated on the other. All allergens suspected of being implicated in the genesis of atopic dermatitis were eliminated from the diet. Clinical improvement was observed in 80% of cases after dietary exclusion. The younger children responded best, and the response to diet was not influenced by the severity of the eczema. No relation was observed between the family history of atopy and response to diet. Neither total nor specific IgE titers presented significant differences when the responder groups were compared.

Adolescent↗