PubMed Health⌕ Search

Biomedical subjects

E Butoianu

Publications and source records attributed to E Butoianu.

6 recordsLinked to original sources
PubMedDate not supplied

Ph1-positive polycythemia vera.

The rare presence of the ph1 chromosome in chronic myeloproliferative disorders other than chronic granulocytic leukemia (CGL), i.e. polycythemia vera (PV), myeloid metaplasia with myelofibrosis (MMM) and hemorrhagic thrombocytopenia (HT) raised the question whether or not the Ph1 chromosome is peculiar to CGL. In an attempt to answer this question, the authors reports six cases of positive-Ph1 of which two are from their personal experience and four from the literature. Three of these six cases converted to CGL. The authors conclude that the cases of Ph1-positive PV and HT are transition forms to CGL, and the cases of Ph1-positive MMM are in fact secondary forms derived from CGL.

Adult↗
PubMedDate not supplied

A preventive therapy of the central nervous system complications in acute leukemias. Preliminary report.

A new therapeutic schedule for preventive therapy of the central nervous system (CNS) complications by intrathecal (i.t.) injections of methotrexate (MTX) was applied in two groups of 6 and respectively 13 adults with acute lymphoblastic or non-lymphoblastic leukemias. Instead of starting this treatment only in the remission stage, i.t. MTX was given from the very beginning of cytostatic therapy. In most of the patients this drug proved to be effective in preventing CNS involvement. In some cases, however, it was not well, tolerated owing probably to a neurotoxic effect. This suggested continuation of the study with Ara-C.

Adolescent↗
PubMedDate not supplied

LAP negative and Ph1-positive hemorrhagic thrombocythemia.

Cytochemical and cytogenetic studies were carried out in 4 patients with chronic myeloproliferative disorders. These corresponded only partially to the clinical and hematologic criteria for the diagnosis of hemorrhagic thrombocythemia (HT), yet with a low leukocyte alkaline phosphatase (LAP) level and in the presence of the Ph1 positive 46, XX, mitoses. The authors discuss the significance of the presence of the Ph1 chromosome as well as the possibility of transition forms among chronic myeloproliferative disorders.

Adolescent↗
PubMedDate not supplied

Congenital dyserythropoietic anemia type II. Radioautographic, ultrastructural and cytogenetical study in two familial cases.

The case of two sisters is reported in whom morphological (multinucleated erythroblasts in the bone marrow) and serological (positive Ham test, negative sucrose and water-sugar tests) characteristics of a congenital dyserythropoietic anemia type II were found. Radioautographic, cytogenetic and electron microscope studies confirmed the presence of an inefficient erythropoiesis and of a membrane defect, common in this disease. The finding of a nil LAP score has never been reported so far.

Adolescent↗