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Biomedical subjects

E C Griesemer

Publications and source records attributed to E C Griesemer.

10 recordsLinked to original sources
PubMed1983

The determination of cocaine and its major metabolite, benzoylecgonine, in postmortem fluids and tissues by computerized gas chromatography/mass spectrometry.

An analytical procedure for the simultaneous determination of both cocaine and benzoylecgonine in postmortem fluid and tissue samples has been developed by using computerized gas chromatography/mass spectrometry and gas chromatography using a nitrogen/phosphorus (N/P) detector. Both methods are accurate and sensitive and allow the determination of tissue concentrations of cocaine and benzoylecgonine as low as 0.015 microgram/mL.

Autopsy↗
PubMed1982

Hydromorphone detected in bile following hydrocodone ingestion.

Two similar cases are reported here in which Tussionex, a preparation containing hydrocodone and phenyltoloxamine, caused or contributed to death. Toxicological analyses revealed a high concentration ratio of hydromorphone to hydrocodone in the bile in both cases. It is postulated that the finding of hydromorphone is due to the metabolism of hydrocodone.

Adult↗
PubMed1976

Antemortem conversion of codeine to morphine in man.

Forty-five drug overdose cases involving codeine were investigated. Concentrations of codeine and morphine were determined in blood, bile, liver, kidney, and urine. Ratios of codeine to morphine values for each of these specimens were compared and evidence was developed that codeine was metabolized partially into morphine in the antemortem stage. Morphine concentration was less than that of codeine in blood, liver, kidney, and urine. However, bile analyses showed that the amount of morphine exceeded that of codeine, suggesting a more active demethylation activity in the hepatic system than in the blood and other tissues studied. Controlled-in-vitro studies showed that no codeine demethylation occurred in postmortem tissues during cold storage for a period as long as 30 days.

Bile↗
PubMedDate not supplied

Procainamide depleted tablets not a cause of death.

Sixteen apparently intact procainamide tablets, in varied stages of drug depletion, were found distributed throughout the gastrointestinal tract of a man who died of arteriosclerotic heart disease with pulmonary complications. The tablets were found to contain procainamide by a thin layer chromatography system with cataloged compound identification characteristics. The drug was confirmed by ultraviolet spectrophotometry and gas chromatography/mass spectrometry. The concentration of the drug in the liver was in a therapeutic range and the drug was not attributed as contributing to the cause of death.

Aged↗
PubMedDate not supplied

The frequency of deaths resulting from the use of drugs and chemicals in Los Angeles County.

A study of the frequency of deaths resulting from the use of drugs and chemicals in Los Angeles County in the period 1947--1980 indicated that there was a substantial increase in the number of such deaths in 1968/69. This trend continued until 1976/77 when the number of deaths decreased, and the declining trend continued until 1979/80. An additional study in the period 1974--1981, based on the analyses of 35 drugs in biological samples taken in autopsies, showed that those drugs were more often present in overdose cases of death than in drug-related cases of death where drugs were not directly responsible fo the occurrence of death. Ethanol and phencyclidine were, however, more frequently found in drug-related cases of death.

Adolescent↗