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Biomedical subjects

E C Huskisson

Publications and source records attributed to E C Huskisson.

At least 109 records · Page 6Linked to original sources
PubMed1979

Osteoarthritis. Changing concepts in pathogenesis and treatment.

The clinical features of osteoarthritis provide little support for the traditional view of the disease as a wear-and-tear phenomenon of aging. In many cases osteoarthritis consists of a polyarthritis with mildly inflammatory features, such as stiffness, effusions, and hot Heberden's nodes. The finding of biochemical abnormalities of cartilage throws new light on this enormously important disease and suggests the possibility of more effective therapy.

Humans↗
PubMed1979

Treatment of rheumatoid arthritis with a single daily dose of benoxaprofen.

A single daily dose of 600 mg of henoxaprofen has been shown to be more effective than a previously reported dosage regime in patients with rheumatoid arthritis. Increased total daily dosage was not associated with a greater incidence of side-effects. The drug worked slowly reaching a plateau after eight days of treatment. It was usually well tolerated especially by the gastro-intestinal tract.

Adult↗
PubMed1979

D-penicillamine and immune complex deposition.

Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum immunoglobulin and complement levels decreased significantly in patients treated with penicillamine. It is suggested that, in addition to penicillamine nephropathy, other side effects of this drug may be related to widespread deposition of immune complexes.

Adult↗
PubMed1979

Another look at osteoarthritis.

One hundred consecutive cases of osteoarthritis seen in a medical clinic have been reviewed and contrasted with 100 patients with rheumatoid disease. Osteoarthritis was usually a polyarticular disease and as symmetrical in distribution as rheumatoid; the knees and hands were the most commonly involved sites. Evidence of inflammation was often found in patients with osteoarthritis and included morning stiffness, redness of distal interphalangeal joints, warmth, and effusions in the knees. In many cases there was either radiological or electron microscopical evidence of deposition of calcium salts. These findings do not support the concept of osteoarthritis as a mechanical, noninflammatory 'wear and tear' condition. An active metabolic abnormality of articular cartilage resulting in cartilage destruction, calcification, and inflammation is suggested as being more compatible with the findings.

Arthritis, Rheumatoid↗
PubMed1979

Accuracy of subjective measurements made with or without previous scores: an important source of error in serial measurement of subjective states.

Pain severity was assessed on visual analogue scale in 4 groups of patients receiving long-term therapy. A comparison was made between pain measurements made with and without access to initial scores. The differences between these measurements increased with the duration of treatment. Patients tended to overestimate their pain severity when previous scores were not available. It is suggested that initial scores should be made available when serial measurements of pain are made in long-term experiments.

Humans↗
PubMed1979

Vertical or horizontal visual analogue scales.

Vertical and horizontal visual analogue scales have been compared in the measurement of pain. There was a good correlation between the 2 scales, but the scores from horizontal scales tended to be slightly lower than those from vertical scales.

Humans↗
PubMed1978

Factors affecting the development of penicillamine side-effects.

Characteristics of patients on penicillamine therapy for rheumatoid arthritis were correlated with the occurrence of different side-effects. Patients developing proteinuria tended to have lower sheep-cell agglutination test titres prior to therapy, but no other correlations were found. It is postulated that rheumatoid factor reacts with immune complexes, causing their precipitation and reducing renal glomerular deposition and therefore the incidence of proteinuria. Penicillamine would surely be the first choice of anti-rheumatic therapy if it were not for its side-effects. It is capable of controlling the disease, but in many cases treatment must be interrupted because of some potentially serious side-effects, such as thrombocytopenia, rash or nephropathy. Understanding the mode of action of a drug may lead to the development of new and better compounds. Similarly, understanding the mechanism of the side-effects may lead to their elimination. This survey was designed to identify factors which influenced the development of particular side-effects in patients receiving penicillamine for rheumatoid arthritis.

Agglutination Tests↗
PubMed1978

Benoxaprofen: a clinical trial with an unusual design.

Benoxaprofen is a new nonsteroidal analgesic anti-inflammatory drug with a long half-life. Preliminary studies showed that steady-state blood levels could be achieved within 24 hours of treatment using a dose of 300 mg on the first day followed by 100 mg twice daily. A double-blind cross-over trial showed that benoxaprofen was effective and well tolerated in rheumatoid arthritis. Its analgesic effect was not apparent until the sixth day of treatment. An unusual trial design was used with treatment periods of unequal duration. This design has the advantage of allowing a new drug to be given for long enough to determine the time course of its action, while sparing patients prolonged treatment with placebo.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1978

Sulindac. Trials of a new anti-inflammatory drug.

Trials in patients with rheumatoid arthritis and osteoarthritis showed sulindac to be an analgesic with anti-inflammatory properties and at least as effective as aspirin. It was effective within 24 hours in doses of 300-400 mg daily. It had the advantages of twice daily administration and a lower incidence of gastric side effects than aspirin. Constipation, usually mild, occurred in 20-30% of cases. Like other anti-inflammatory drugs, it was effective in only a proportion of the patients.

Arthritis, Rheumatoid↗