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Biomedical subjects

E C Kingsley

Publications and source records attributed to E C Kingsley.

5 recordsLinked to original sources
PubMed1989

Trisomy 14: a new entity within acute nonlymphocytic leukemia.

Three cases of acute nonlymphocytic leukemia with trisomy 14 as the sole chromosome abnormality are presented and it is suggested that this type of trisomy, either as an extra chromosome or an isochromosome, is phenotypically equivalent. The findings are presented in relation to other cases previously reported.

Aged↗
PubMed1987

Acute promyelocytic leukemia.

Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia frequently associated with disseminated intravascular coagulation (DIC). Data on 11 patients with APL treated at our institution were analyzed and compared with those of 147 published cases. Most had a bleeding diathesis at presentation and evidence of DIC eventually developed in all. Seven patients (64%) showed the t(15;17)(q22;q21) karyotype or a similar translocation. Using a chemotherapy induction regimen containing an anthracycline, complete remission, requiring a total of 14 courses of treatment, was achieved in six patients (55%). The median duration of response and median survival for complete responders were 10 and 15 months, respectively. Three patients (27%) died of bleeding complications during induction therapy. The tritiated-thymidine labeling index of leukemia cells predicted which patients would achieve a complete remission. Review of six studies of 147 patients with APL from the past 12 years supports the use of a chemotherapy induction regimen containing anthracycline or amsacrine and heparin for the treatment of DIC.

Antineoplastic Agents↗
PubMed1986

Prolonged survival in patients with treatment-related leukemia.

We summarize the findings in 2 patients with treatment-related acute leukemia, who have had prolonged disease-free survival (62 and 84 months, respectively). The 1st patient developed acute myelogenous leukemia after receiving whole pelvic radiation and chlorambucil daily for 7 yr, as treatment for Stage III ovarian carcinoma; and the 2nd patient received cyclophosphamide, doxorubicin, vincristine and prednisone for Stage IV non-Hodgkin's lymphoma and subsequently developed acute monoblastic leukemia. The most remarkable finding is the unusually prolonged survival of both these patients with what is generally considered to be a very poor prognostic type of leukemia (mean survival less than 6 months). One predictive factor may have been the normal chromosomes in 1 patient. Since prolonged survival is possible in treatment-related leukemia, it is recommended that aggressive induction chemotherapy be at least considered for all such patients.

Antineoplastic Agents↗