E C McCoy — Page 4 | PubMed Health

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Airplane emissions: a source of mutagenic nitrated polycyclic aromatic hydrocarbons.

Organic solvent extracts from airplane emission particulates are mutagenic for Salmonella typhimurium strain TA98. Using Salmonella tester strains deficient in enzymes required for the bioactivation of various nitroarenes, the mutagenicity present in these emissions was ascribed to the presence of nitrated polycyclic aromatic hydrocarbons. Based on the known aircraft particulate emission rates at U.S. airports, and using 1-nitropyrene (1-NP) and 1,8-dinitropyrene (1,8-DNP) as surrogates, it is calculated that at a minimum 7 kg 1-NP and 20 g, 1,8-DNP are emitted daily at a typical U.S. airport.

Air Pollutants↗

PubMedDate not supplied

Comparative mutagenesis by aminofluorene derivatives. A possible effect of DNA configuration.

The mutagenicity of N-acetoxy-N-2-acetylaminofluorene (N-acetoxy- 2AAF ) for Salmonella typhimuricum TA98 is greatly reduced when compared to that of N-hydroxy-2-aminofluorene. This decrease in mutagenic response is accompanied by the formation of a deoxyguanosine-2-acetylaminofluorene adduct. The deoxyguanosine-2-aminofluorene adduct, characteristic of cells exposed to N - hydroxy-2-aminofluorene, was not detected in N-acetoxy- 2AAF -treated cells. Enzymic deacetylation of N - acetoxy- 2AAF results in restoration of potent mutagenicity. N-Acetoxy-2-acetylamino-7- iodofluorene is also more mutagenic than N-acetoxy- 2AAF . Because the acetylated and unacetylated guanine adducts induce greatly different configurational changes, the results may be indicative that the introduction of the syn configuration and a possible shift to the Z-conformation at the mutational hot spot of Salmonella typhimurium TA98 [(dG-dC)8] results in reduced mutagenic potency.

Chromatography, High Pressure Liquid↗