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E Cacciola

Publications and source records attributed to E Cacciola.

84 records · Page 5Linked to original sources
PubMedDate not supplied

Early response to alpha interferon in a patient affected by hairy cell leukemia.

A 61-year-old splenectomized male patient affected by hairy cell leukemia (HCL) in relapse was treated with interferon (IFN) at a dosage of 3 x 10(6) U/day. After only 11 days of treatment, IFN was stopped because the patient developed fever, jaundice and respiratory distress. Upon recovery from this infectious episode, the patient was judged to be in complete remission of HCL on the basis of clinical and laboratory findings, and he remained off-therapy for 2 years. When an overt relapse occurred, the patient was again treated with IFN and, after a very short time, he achieved a new, good partial remission that is maintained 28 months later without treatment. This observation remains speculative for understanding the mechanism of action of IFN in other comparable HCL cases.

Combined Modality Therapy↗
PubMedDate not supplied

Multiple myeloma and renal transplant.

Until now, no case of multiple myeloma (MM) had been reported among the B-lymphoproliferative disorders occurring in organ-transplant recipients. The history of a 58-year-old man who developed IgG-kappa MM 31 months after a cadaveric renal transplant is described. A possible relationship between drug-mediated immunosuppression and the development of MM is discussed.

Azathioprine↗
PubMedDate not supplied

Vitro drug-induced apoptosis in freshly isolated leukemic cells: a flow cytometric analysis.

Fludarabine is considered a useful drug in the management of B-CLL resistant to conventional chemotherapy as it is able to trigger apoptosis in neoplastic B cells. In order to analyze this aspect, we tested by means of a simple and rapid flow cytometric method the in vitro apoptotic response of CD5+ B-CLL lymphocytes to FAMP, in comparison with other cytoreductive agents such as Interferons. Our findings showed that apoptosis occurred significantly in lymphocytes cultured with FAMP, but not with IFNs. In conclusion, flow cytometry allows an easy and rapid detection of in vitro drug-induced apoptosis, possibly representing also a reliable assay for testing tumor cell sensitivity or resistance.

Apoptosis↗
PubMedDate not supplied

Cutaneous vasculitis in non Hodgkin's lymphoma.

Cutaneous vasculitis has been described in association with various hematological malignancies, but it seems to be very uncommon among non Hodgkin's lymphomas (NHL). For this reason no attention has been given to the peculiarity of this rare association. We identified 5 cases of cutaneous vasculitis among 315 NHL patients examined at our Institution from 1984 through 1990 and after the appearance of vasculitis, we observed some heterogeneity in either the degree of activity or in the clinical outcome of the NHL. The onset of cutaneous vasculitis appeared to mark two different clinical patterns: a vasculitis present from diagnosis characterized an indolent course of the neoplasia, while a late-appearing vasculitis was followed by rapid lymphoma progression and short survival.

Adult↗