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Biomedical subjects

E Canducci

Publications and source records attributed to E Canducci.

2 recordsLinked to original sources

Dietary habits and multiple sclerosis. A retrospective study in Ferrara, Italy.

In a retrospective case-control study of multiple sclerosis (MS), set up with the aim of verifying the role of environmental factors in pathogenesis, we included a section on dietary habits. We compared the frequency and pattern of food consumption by cases and controls. We found an association between. MS and high consumption of bread and "pasta", butter and lard, legume soup, horse flesh, coffee and tea in the period from infancy to adolescence. A different pattern of consumption of eggs, wine and mineral water between cases and controls was found during adulthood. Our results support, at least partially, the data already reported in the international literature on an association between certain dietary factors and MS. Some foods consumed at certain "critical" ages could play a causal role in the onset of MS.

Adolescent↗

Vitamin E in beta-thalassemia.

In homozygous beta-thalassemia low serum level of alpha-tocopherol have been found. The administration of high doses of the vitamin increased the serum level, decreased lipid peroxidation and, in some case, prolonged red blood cell survival; no significant change in transfusion requirement was obtained. Only few data are available about the vitamin E in heterozygous beta-thalassemia. We have studied 131 patients aged 1 to 72 years with thalassemic trait and 218 age-matched controls. Serum level of alpha-tocopherol was statistically lower in the former. We have studied the effect of vitamin E on 10 patients. In each subject the subsequent parameters were determined before and after a three month treatment (vitamin E 400-600 mg/day) glutathione peroxidase, pyruvate kinase and creatine in erythrocytes serum vitamin E and red blood cell count. Hematological values were unchanged in all patients. In half of them biochemical parameters showed reduction of lipid peroxidation and increased erythrocyte survival.

Adolescent↗