[The effect of physical stress on the repair of isoprenaline damage to the myocardium].
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Biomedical subjects
Publications and source records attributed to E Cerný.
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In this experimental work we evaluated the effect of preventively administered Cordarone on the myocardial damage of rats, caused by isoproterenol. Cordarone had prevented the early mortality of rats up to 1 h, however, after the administration of high doses of Cordarone the late mortality of experimental animals was increased. In the group of rats, which were treated by Cordarone there were almost no small necroses of myocardium, which were, however, contrary--very often found in the control animals. We guess that this effect of Cordarone is caused by its influence on the heart rate, which is slowing down, by its antiarrhythmic effect and by its efficiency to improve the perfusion of myocardium by its power to decrease the resistance of coronary vessels.
Influence of Neo-Gilurytmal was studied upon catecholamine heart lesion in rats of two weight categories: In bigger ones (350-420 g) the lesion was diminished, in smaller animals (200-230 g) any protective influence did not occur. Sensitivity of myocardium to Neo-Gilurytmal is supposed to concur with that to catecholamine effect in rats of increasing weight.
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Two autoptic cases of chondroosteoplastic tracheopathy yielded features defining the lesion: continuous shrubby proliferation of the inner surface of tracheal cartilages developed bony lamellae in connection with cells of mucosa.
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The development of rat myocardial lesion induced by isoprenaline was studied under the influence of Faustan, morphine and Spasmo-eunalgit. A protective effect diminishing the myocardial lesion was limited to morphine.
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ATP failed to influence the rate of myocardial healing having been administered to rats 1 hour after Isoprenaline. Further long-term administering of ATP diminished the intensity of repeated myocardial lesion due to catecholamine. However, myocardial fibrosis was not sure to be influenced.
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