E Champlin | PubMed Health

PubMed1982

Chronic urticaria and angioedema.

Of 231 patients evaluated for chronic urticaria and angioedema (CUA), 192 were diagnosed as having an idiopathic condition. The roles of serum IgE, complement (CH50), and immune complexes (IC) were investigated in 112 patients with idiopathic CUA. Immediate skin tests were not helpful, but total IgE was elevated in 13%, equally divided between dermographic (D) and non-dermographic (ND) patients. Depressed haemolytic complement (CH50) was noted in 10% of CUA, all of whom were D. Serum IC were elevated in 38% equally divided between D and ND patients. There was no relationship between depressed CH50 and elevated IC. Skin biopsies, evaluated by both light and immunofluorescent techniques, were negative for all specimens tested. The pathophysiology of idiopathic CUA is multifactorial, with a variety of immunological mechanisms involving serum IgE, CH50, and IC. . The relationship between depressed CH50 and dermographism was noted but unexplained by serum or tissue studies.

Adenocarcinoma↗

PubMed1982

Clinical significance of screening for antibody to ribonucleoprotein.

Of more than 1500 sera screened for antinuclear antibody 13 were positive for antiribonucleoprotein (RNP). Nine patients had either systemic lupus erythematosus or mixed connective tissue disease. Four other had no significant medical problems. The detection of anti-RNP antibody does not have diagnostic specificity and may not indicate active collagen disease.

Adrenal Cortex Hormones↗

PubMed1982

Chronic urticaria dnd vasculitis.

Of 231 patients with chronic urticaria, eight presented with arthritis. All had elevated sedimentation rates, five had depressed complement (CH50) and two elevated serum immune complexes (IC). Skin biopsies were abnormal in only four patients, unrelated to abnormalities of CH50 or IC. No single diagnostic test was consistently abnormal.

Angioedema↗