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Biomedical subjects

E Chodosowska

Publications and source records attributed to E Chodosowska.

At least 19 recordsLinked to original sources
PubMed1998

Emotional status does not alter exercise tolerance in patients with chronic obstructive pulmonary disease.

Exercise tolerance in chronic obstructive pulmonary disease (COPD) patients has been shown to be related to airway limitation and dyspnoea, but little is known about the effects of an emotional status on physical performance. We examined 49 COPD patients with a wide spectrum of airway limitation severity and hypoxaemia. Exercise tolerance was evaluated using the Six-minute Walking Distance Test (6MWD), dyspnoea at rest and on exercise was measured using the visual analogue scale, and the emotional status was evaluated using the battery of psychological tests. The average 6MWD (mean+/-SD) was 355+/-112 m. In the majority of patients a fall in arterial blood oxygen saturation (Sa,O2) on exercise of >3% was found. The mean dyspnoea score of 21+/-19 at rest increased to 66+/-19 on exercise. All subjects demonstrated an increased level of anxiety. The majority also demonstrated elevated emotional tension, and half of the study group showed signs of depression. Step-wise multiple regression analysis with results of 6MWD as dependent and other studied variables as independent variables showed that exercise tolerance depended mainly on airway limitation. The forced expiratory volume in one second (FEV1) explained 24% of the variance. The forced vital capacity added a further 10%, and arterial blood carbon dioxide tension contributed 7%. The dyspnoea level on exercise added only 0.9%. All four variables explained 42% of the variance. There was no correlation between 6MWD and any of the variables characterizing the emotional status. We conclude that the emotional status of chronic obstructive pulmonary disease patients is characterized by an increased level of psychological tension, anxiety and depression, but these do not affect exercise tolerance as assessed by the six-minute walking distance test.

Anxiety↗
PubMed1992

[Natural history of pulmonary hypertension in chronic obstructive lung diseases and the usefulness of the simple noninvasive methods of its diagnosis].

In 47 patients with chronic obstructive pulmonary disease and 19 patients with idiopathic pulmonary fibrosis pulmonary haemodynamics were studied. Pulmonary arterial pressure was compared with non-invasive lung function tests, ecg and the chest X-ray. Correlations between pulmonary arterial pressure and some of those parameters were found. Investigations were repeated after 3 or 5 years depending on severity of pulmonary hypertension initially found. The progression of pulmonary hypertension was found. It was accompanied by intensification of non-invasive indices of pulmonary hypertension. More than half of patients with initially severe pulmonary hypertension (> or = 30 mmg Hg) did not survive 3 years.

Adult↗
PubMed1992

[Evaluation of the relations between exercise tolerance, dyspnea and pulmonary function in patients with chronic obstructive lung diseases].

We studied 53 patients with severe COPD (FEV1 0.92 +/- 0.40 1, PaO2 61 +/- 9 mm Hg), aged 58 +/- 9 years, to assess the relationship between ability to exercise (6 MWD), dyspnea and baseline lung function parameters. Dyspnea at rest (D1) and during exercise (D2) was evaluated using VAS. During exercise dyspnea increased by 41 +/- 28, and oxygen saturation (StcO2) decreased from 92 +/- 3% to 84 +/- 9%. The fall in the StcO2 of more than 3% was observed in 42 patients (79%). We found that 6 MWD significantly correlated with the FEV1, VC and maximal dyspnea during exercise. There was no correlation between exercise tolerance and resting PaO2, PaCO2, severity of dyspnea at rest and the increase in dyspnea during exercise as well as with the resting and exercise StcO2 and the fall in StcO2 during walk. Dyspnea at rest and during exercise significantly correlated with air flow limitation and StcO2 at rest, during exercise and the exercise decrease in StcO2. There was a significant correlation between the fall in StcO2 during exercise and blood gases at rest. No relationship between the fall in StcO2 and the increase in dyspnea during exercise was found.

Dyspnea↗
PubMed1992

[Dyspnea at rest and after exercise and the mental status of patients with chronic obstructive lung diseases].

Thirty two patients with severe COPD were studied. We evaluated relationships between their psychological status, lung function parameters, exercises tolerance (6 MWD test) and dyspnea at rest and exercise (visual analogue scale). Patients demonstrated increased level of anxiety and psychological tension. In nearly half of the patients depression, low self-esteem and disbelief in the efficiency of therapy were observed. The correlations between the psychological status and the exercise tolerance hasn't been found. The correlation between the high level of depression and impairment of the lung function was found. The high increase in dyspnea score during exercises was connected with low self-esteem, although at rest the dyspnea level in those patients was low.

Adult↗
PubMed1991

[Control of respiration in patients with respiratory insufficiency in chronic obstructive lung disease].

Twenty eight COPD patients with respiratory insufficiency were studied. These included: 12 hypoxemic and normocapnic patients, 16 hypoxemic and hypercapnic patients, and 22 healthy volunteers. During at rest respiration both COPD groups differed from the control group--demonstrating a higher respiratory incidence, VT/Ti and PO2 values. During hypercapnic stimulation using the rebreathing method the ventilatory response to CO2 in the COPD patients was lowered in comparison with the control. Increase of occlusion pressure as a response to the increasing hypercapnia was lowered in both groups, significantly in patients with hypercapnia.

Adult↗
PubMed1989

[Pulmonary arterial pressure and the effect of short term oxygen therapy on it in patients qualified for home oxygen treatment].

Forty patients with chronic bronchitis and emphysema qualified for domiciliary oxygen treatment according to widely accepted criteria were assessed. Only two patients had normal pulmonary artery pressure. Pulmonary arterial pressure correlated well with oxygen arterial partial pressure. It seems that pulmonary hemodynamic studies are not necessary in patient qualification for domiciliary oxygen therapy. Short oxygen therapy (30 min.) produced only a small decrease of pulmonary artery pressure from 31 +/- 10 to 29 +/- 8 mm Hg. Only in 7 patients was the fall greater than 5 mm Hg. Fall of pressure in pulmonary artery produced by oxygen correlated only with initial pulmonary artery pressure and rose proportionally with increase of pressure.

Adult↗
PubMed1987

Mixed venous blood oxygen tension is not a good predictor of survival in patients with chronic obstructive lung disease.

In a recent study, Kawakami et al, suggested that mixed venous blood oxygenation (PvO2) is one of the most important prognostic factors in patients with chronic obstructive lung disease (COLD). The aim of the present study was to evaluate the predictive power of PvO2 in 99 of our own patients with COLD. Lung function and pulmonary hemodynamics were investigated in a stable period of the disease. Follow-up studies were done at least 3 years after initial work-up. Observation time was 5.4 +/- 1.6 years in patients who survived (S) and 2.8 +/- 2.3 years in patients who died (N-S). The two groups differed significantly in the following variables (mean +/- SD for survivors and non-survivors): VC 3.0 +/- 1.0 1 and 2.3 +/- 8.1 1, FEV1 1.6 +/- 0.9 1 and 0.9 +/- 0.4 1, PaO2 9.6 +/- 1.4 and 8.3 +/- 1.7 kPa, SaO2 94 +/- 3% and 90 +/- 6%, PaCO2 5.0 +/- 0.9 kPa and 5.9 +/- 1.1 kPa, mean pulmonary arterial pressure (PAP) 2.6 +/- 0.7 kPa = 19.5 +/- 5.6 mmHg and 3.9 +/- 1.7 kPa = 29.4 +/- 12.9 mmHg, and hematocrit (Ht) 47 +/- 5% and 51 +/- 7%. The following three variables did not differ significantly: cardiac index 3.8 +/- 1.8.1 and 3.3 +/- 1.6, PvO2 5.6 +/- 0.9 kPa and 5.3 +/- 0.9 kPa, and coefficient of oxygen delivery (COD) 5.69 +/- 2.28 and 5.29 +/- 2.35. The number of patients with signs of tissue hypoxia (PvO2 less than 4.66 kPa) was similar in both groups, 7 (S) and 9 (N-S).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1980

Plasma catecholamines during exercise-induced bronchoconstriction in bronchial asthma.

Plasma levels of adrenaline and noradrenaline during and after submaximal exercise in patients with bronchial asthma were investigated. Three groups were studied comprising 10 patients with exercise-induced bronchoconstriction (EIB), 10 asthmatic patients without EIB and four normal control subjects. Plasma catecholamines were measured at rest, at the end of exercise, and five and 15 minutes after exercise. Changes in airway resistance were assessed by measuring peak expiratory flow rate. Significant differences in catecholamine levels between reacting and non-reacting patients were found. In 10 patients developing EIB adrenaline and noradrenaline levels had risen significantly by the end of exercise and remained elevated up to the fifth minute of recovery. The rise in catecholamine levels in non-reacting asthmatics was insignificant. In control subjects noradrenaline had increased significantly by the end of exercise.

Adult↗