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Biomedical subjects

E Cichocka-Jarosz

Publications and source records attributed to E Cichocka-Jarosz.

10 recordsLinked to original sources
PubMed2001

[Montelukast in treatment mild chronic asthma].

UNLABELLED: The efficacy of montelukast, a leukotriene receptor antagonist, in treatment of mild asthma was evaluated. METHODS: Thirty children aged 6 to 14 years with mild persistent asthma (asthma history more than 12 months and > or = 15% FEV1 improvement after inhaled beta 2-agonist in the past, good control of asthma with inhaled cromolyn or budesonide in the last three months) were enrolled. The study included three periods (2 week's each): washout, placebo, and montelukast. Asthma symptoms score (range 0-5) and PEF were estimated twice daily by children. Spirometric parameters FEV1 and MEF50 were measured during three consecutive visits: on the day of study inclusion, on the last day of the placebo and montelukast period. RESULTS: The mean value of asthma symptoms score was significantly lower during the montelukast period in comparison with placebo (p = 0.038). The mean PEF values were significantly higher during the montelukast vs. placebo period (p = 0.0091). Moreover, in the montelukast period, the mean PEF values in the second week were significantly higher than those in the first week (p = 0.003). The mean FEV1 predictive value in the last day of the montelukast period was higher, though not significantly, than on the day of study inclusion and on the last day of the placebo period. A similar change in mean MEF50 values was observed. CONCLUSION: In children aged 6-14 years with mild persistent asthma, montelukast treatment significantly diminishes asthma symptoms and increases mean PEF values comparing to placebo.

Acetates↗
PubMed1998

Induction of allergy to new aeroallergens during specific immunotherapy (SIT) in grass pollen sensitive patients.

In the group of 50 patients suffering from grass pollen allergy and successfully treated with SIT for three consecutive years, we observed in 5 persons after the end of this treatment the induction of allergy to new allergens (to weeds, mites or tree) manifested by the change of the symptoms season. The induction of the new kind of allergy was confirmed by revealing of the positive skin prick tests to new allergens and by an increase of the specific IgE serum level to them. Despite disappearance of the symptoms of the illness during grass pollen season in all 5 patients we noted the higher total IgE as well as specific to grasses IgE serum level, in comparison to the value at the start of SIT. In the paper the possible mechanisms of this phenomenon are discussed, which seems to be not connected with the natural development of allergy and which confirms once more that during SIT individual changes in humoral and cellular immunity of the patient take place, sometimes very difficult to be predicted. They may among others switch clinical profile of allergy, what indicates that patient during SIT should be under the careful immunological supervision.

Adolescent↗
PubMed1997

[Bronchial asthma: do boys or girls have the highest incidence?].

The aim of the study was to assess the gender related prevalence of asthma and asthma symptoms in schoolchildren. The survey was performed using standardized ISAAC questionnaire in two age groups: 6-7 yr. (n = 2281; girls 49.7%) and 13-14 yr. (n = 4849; girls 49.8%). It was revealed that in older group the prevalence of ever diagnosed asthma was lower in girls than in boys (2.0% versus 3.3%; odds ratio [OR] = 0.58; p = 0.004). But the prevalence of symptoms: wheeze ever (OR = 1.16; p = 0.056), current wheeze (last 12 mo) (OR = 1.26; p = 0.029), current exercise wheeze (OR = 1.40; p = 0.0008), current night cough (OR = 1.67; p = 0.0001) were higher in girls than in boys. However, in younger group of schoolchildren the prevalence of ever diagnosed asthma and asthma symptoms were higher in boys (5.1% male versus 3.5% female). The girls in comparison to boys revealed lower risk of ever asthma diagnosis (OR = 0.66; p = 0.056) and symptoms: wheeze ever (OR = 0.63; p = 0.0001), current wheeze (OR = 0.69; p = 0.003), current exercise wheeze (OR = 0.59; p = 0.008) and current night cough (OR = 0.70; p = 0.0003).

Adolescent↗
PubMed1997

[Diagnostic value of selected eosinophil activity parameters in children with hay fever].

Seventy three children aged 5-15 years were involved in the survey. Thirteen children suffered from seasonal allergic rhinitis (SAR), fourty four children suffered from seasonal allergic rhinitis and bronchial asthma (SAR-A), sixteen patients with no allergic symptoms were treated as a control group (CG). All the patients were examined twice: in July--during the highest pollen season and in December--period free of pollen. During each examination samples were collected to measure the following parameters: blood eosinophilia, serum eosinophil cationic protein (ECP) and eosinophil percentage in the nasal mucosal smears (nasal eosinophilia). In statistical analysis values of all parameters in pollen and free of pollen seasons were compared the groups of patients as well as within the groups. In winter values of: blood eosinophilia, ECP and nasal eosinophilia were statistically higher in SAR-A group in comparison to SAR group and CG, simultaneously there was no statistical difference in blood eosinophilia and ECP between SAR group and CG. In the pollen season the highest values of all parameters were observed in SAR-A group. SAR group values were higher in comparison to control group. The difference between groups was significant. Both groups of allergic patients (SAR, SAR-A) revealed statistically higher values of all measured parameters in pollen season in comparison to winter. In CG only level of ECP was significantly higher in July than in December.

Adolescent↗
PubMed1997

[Pollen allergy. I. Pathophysiology and clinic].

Pollen allergy constitutes about 1/3 of allergic disorders in people. Clinical manifestation of the disease depends on the natural allergen exposure. Main clinical symptoms are dealing with conjunctivitis, allergic rhinitis, bronchial asthma. Permanent increase in number of pollen sensitive patients observed during last years, depends on atopic genetic background, as well as natural allergen exposure and other environmental factors. Better understanding of pathophysiological mechanisms underlying the disease and opportunity to monitor the degree of allergen exposure seems to play the vital role in current treatment and prophylaxis. The allergic reaction takes place in two phases--the first one--early response (EAR) depends on IgE receptors binding which results in mast cell and basophils activation, in the second one--the late response (LAR), adhesive molecules, eosinophils, lymphocytes and their products, as well as neuropeptides are engaged. Also homeostasis of respiratory tract mucous membrane plays an important role at this stage.

Basophils↗
PubMed1997

[Pollen allergy. II. Diagnosis and treatment].

Pollen allergy--one of the most frequent allergies in people is diagnosed by combined data, derived from patient's history together with in vitro and in vivo examinations. Basic in vivo examinations consist of skin prick tests with chosen allergens, functional tests of upper and lower respiratory tract, specific as well as non-specific nasal and bronchial challenge tests. The major role among in vitro examinations is played by those tests, which confirm atopic background of the disease (total and specific IgE). Other tests, like those for T-cell function and tests for effector cells activation, have secondary importance. Patients who are asymptomatic but endangered by the possibility of symptoms occurrence, are treated by primary prevention. Complex therapeutical approach consists of causal treatment (identification of allergens, specific immunotherapy), secondary prevention and symptomatic pharmacology.

Bronchial Provocation Tests↗
PubMed1996

[Value of selected parameters for monitoring efficacy of specific immunotherapy in allergic disorders].

Prevention, pharmacotherapy and specific immunotherapy are used as methods to treat patients with allergic disorders of respiratory system. SIT as a method of controlled supply of allergen, releases immunological mechanisms related to humoral, cellular and effector organic response. Role of those mechanisms and type of changes, taking place can be monitored with given immunological parameters. Most convincing proof of effectiveness of desensitisation, is diminishing of manifestation of clinical symptoms. In patients treated with obvious therapeutical progress, tolerance of increased dose of allergen was noted.

Humans↗
PubMed1995

Congenital stridor.

Fifty-two infants and children with stridor were examined. The median age was 5 months and the boy/girl ratio was 2:1. Fiberoptic bronchoscopy was performed when other diagnostic methods had failed to establish the origin of stridor. The most common cause of stridor was laryngomalacia, which was found in 34 children (65%). The most common form of laryngomalacia was due to large, floppy arytenoid cartilages; this was observed twice as often as other forms of laryngomalacia and boys suffered from this abnormality more than twice as often as girls. Children with laryngomalacia had significant weight (24%) and height (8%) deficits in comparison with the normal healthy population (P < 0.001). In all but four patients with laryngomalacia, blood gases were within normal limits. In 18 children (35%) stridor was not caused by laryngomalacia. This group showed significant etiologic heterogeneity. However, identification of the cause of stridor in these patients is important because specific treatment can be offered and prognosis depends on the type and cause of the anatomical and functional abnormality present.

Bronchoscopy↗
PubMed1992

[Foreign bodies in respiratory tracts of children treated at the Institute of Pediatrics in Krakow during the years 1987-1991].

Foreign bodies aspirated into respiratory tract may produce severe lung damage and threaten life. We have analysed retrospectively symptoms, physical findings, chest roentgenograms and bronchoscopy reports in 20 children with foreign body aspiration. Boys dominated in this group. Foreign body aspiration often accompanied by coughing, wheezing and vomiting. In chest X-ray examination it was revealed unilateral body trapping and obstructive emphysema. Foreign body aspiration should be considered in children with prolonged respiratory tract problems even when no adequate history is present and with negative chest roentgenograms.

Adolescent↗