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E Cingolani

Publications and source records attributed to E Cingolani.

At least 19 recordsLinked to original sources
PubMed2005

Post-traumatic stress disorder-related symptoms after intensive care.

AIM: To determine the incidence of Post Traumatic Stress Disorder (PTSD) related symptoms in a population of intensive care unit (ICU) admitted patients and the relationship between PTSD-related symptoms and memories of ICU. METHODS: Adults consecutively admitted to an ICU of a University hospital during 1 year, who stayed in the ICU at least 3 days, were prospectively studied. A questionnaire (ICU memory tool) was administered to 84 patients 1 week after ICU discharge and to 63 of them after 3 months. Past medical history and clinical variables present during ICU stay were collected. RESULTS: At the 1st interview, 5 patients (5.9%) did not remember to have been in ICU. Of the remaining 79 patients (males 59.5%, median age 69 years, SAPS II 34, APACHE II 14 and ICU stay 5 days), 4 reported intrusive memories and none panic attacks. The Impact of Events Scale (IES), available in 3 of them, scored in medium/high levels. Only the median number of factual memories reported by the patients with and without intrusive memories was significantly different (4 interquartile range 2-5 vs 8 interquartile range 6-10; p=0.002). The patients with intrusive memories at the 1st interview did not report them at the 2nd interview. Two patients not having panic or intrusive memories at the 1st interview reported PTSD-related symptoms after 3 months. CONCLUSIONS: In a general ICU population, few patients (5%) have PTSD-related symptoms and those who present those symptoms report less factual memories of ICU stay.

Aged↗
PubMed2001

Analgesia, sedation, and memory of intensive care.

PURPOSE: The purpose of this article was to investigate the relationship between analgesia, sedation, and memory of intensive care. PATIENTS AND METHODS: One hundred fifty-two adult, cooperative intensive care unit (ICU) patients were interviewed 6 months after hospital discharge about their memory of intensive care. The patient was considered to be cooperative when he/she was aware of self and environment at the interview. The patients were grouped as follows: A (45 patients) substantially no sedation, B (85) morphine, and C (22) morphine and other sedatives. RESULTS: The patients having no memory of intensive care were 38%, 34%, and 23% respectively, in the three groups. They were less ill, according to SAPS II (P <.05), and had a shorter ICU stay (P <.01). Group C patients were more seriously ill according to SAPS II, duration of mechanical ventilation, and length of stay in ICU and in hospital (P <.001). The incidence of factual, sensation, and emotional memories was not different among the three groups. Females reported at least one emotional memory more frequently than males (odds ratio 4.17; 95% CI 10.97-1.59). CONCLUSIONS: The patients receiving sedatives in the ICU are not comparable with those receiving only opiates or nothing, due to the different clinical condition. The lack of memory of intensive care is present in one third of patients and is influenced more by length of stay in ICU than by the sedation received. Sedation does not influence the incidence of factual, sensation, and emotional memories of ICU admitted patients. Females have higher incidences of emotional memories than males.

Adult↗
PubMed1992

A gas-chromatographic determination of the ppb levels of volatile halogenated hydrocarbons in water for injections.

Some volatile halogenated hydrocarbons have been found in commercial large volume parenterals (LVPs) prepared from untreated or treated (disinfected) water. To monitor the presence of volatile halogenated hydrocarbons in the source water and also in the water for injections, a low cost and sufficiently simple procedure has been developed, specifically for the following components: 1,1,1 trichloroethane, 1,1,2 trichloroethylene, 1,1,2,2 tetrachloroethylene, carbon tetrachloride, chloroform, dichlorobromomethane and dibromochloromethane. A Head-space technique coupled with ECD-gaschromatography was used. The procedure is thoroughly discussed in the article, including the results of a ring test for a preliminary validation of this method.

Chromatography, Gas↗
PubMed1985

Physical parameters and biological activity of sulfonamides.

The activity coefficients "gamma" aqueous solution and the diffusion rate constants (Kd) from artificial gastric and intestinal juices were measured for eleven sulfonamides; the corresponding absorption rate constants (Ki) were then calculated. The activity coefficient was correlated with various parameters, such as the n-octanol/water and isoamyl acetate/water partition coefficients, and the absorption constant. The activity coefficient "gamma" plays an important role on the global biological activity, even if partly depending upon chemical interactions. Constant ratios (about 10%) referred to solubility of the sulfonamidic compounds in the "amorphous state" were regarded as available in blood for biological activity, regardless of the respective binding with plasma proteins.

Chemical Phenomena↗
PubMed1978

[Evaluation of biological activity of organic substances by measuring the physico-chemical parameters (author's transl)].

For a particular form (amorphous phase) of physical acting substances the water solubility, in conditions very close to the in vivo ones, has been compared with corresponding biological activities. The reciprocal of the above parameter shows a good correlation with various physico-chemical, biochemical and pharmacological parameters of xanthinic compounds, analgesic alkaloids, barbiturates, sulphonamides. The solubility of the crystalline phase cannot be correlated with the biological activity: the ratio between these two solubilities shows this inability.

Alkaloids↗