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Biomedical subjects

E Conradi

Publications and source records attributed to E Conradi.

17 recordsLinked to original sources
PubMed1998

Evaluation of enalapril combined with diltiazem ER in patients with stage 3-4 essential hypertension.

Enalapril combined with an extended-release formulation of diltiazem was evaluated in a 12-week multicenter trial of 112 patients with Stages 3-4 essential hypertension. Patients were randomized to once daily therapy with enalapril 5 mg plus diltiazem ER 120 mg or 180 mg. Dosages could be titrated and other antihypertensive agents added for blood pressure control. Efficacy was assessed with sitting blood pressures at trough (24 hours postdose). Overall, there was a decrease of -21.7/-18.4 mmHg. Patients responding to enalapril/diltiazem ER alone had a reduction of -15.0/-16.3 mmHg. Of all patients, 70% achieved a trough sitting diastolic blood pressure of < 95 mmHg. Common drug-related adverse experiences were headache, dizziness, rash, and asthenia/fatigue. This once daily fixed-combination of enalapril/diltiazem ER was generally well tolerated and effective when given alone or with other antihypertensives in Stage 3-4 hypertension.

Adult↗
PubMed1996

[Hemodynamics in arterial hypertension treated with running endurance training or nifedipine therapy].

This is a report about the therapeutic behavior of blood pressure and heart rate in patients suffering from hypertension. Forty male patients with hypertension (age: 30-53 years) were treated either with running or swimming therapy according to the stamina principle or with nifedipine therapy (40-60 mg/d). Both groups were randomized. Peripheric hemodynamics were investigated by means of the Xenon-133-muscle-clearance (M. tibialis anterior). The values of interest were half-value time (T1/2) and the mean functional vessel diameter. Additionally total peripheric vascular resistance (TPR) and radiocardiographic cardiac output (CO) were measured. Significant decrease of systolic and diastolic blood pressure values at rest were obtained with the therapeutic regimens. CO increased and the TPR decreased. The decrease of blood pressure during physical therapy and with nifedipine therapy also is due to the enhanced microcirculation. Half-value time of muscle clearance (T1/2) and the mean functional vascular diameter were increased significantly.

Adult↗
PubMed1989

Effects of continuous and pulsed microwave irradiation on distribution of heat in the gluteal region of minipigs. A comparative study.

Eleven experiments were conducted on minipigs for the purpose of determining heat distribution in tissue exposed to therapeutic doses of microwaves. Temperatures were measured by means of coated thermocouples from the cutis, subcutis, musculature, and periost. Irradiation was applied to intensities of 10 W, 40 W and 60 W by means of a "Radarmed 12 S 251" circular emitter and to 60 W, 100 W and 140 W, using a trough emitter. Maximum temperature in superficial tissue layers was reached after five to ten minutes of microwave exposure. The temperature rise in the cutis and subcutis was steeper and at a higher rate than that in the muscles. Continuation of microwave irradiation did not cause any further rise in temperature, which was attributed to induction of hyperaemia. No difference regarding heat distribution was found to exist between pulsed and continuous irradiation at equal wattage.

Animals↗
PubMed1988

[Physical therapy in chronic obstructive lung diseases].

Based on the definition of physiotherapy as having functional orientation aiming to stimulate reactive processes of body itself, the position of physiotherapy is outlined. The most important methods for the treatment of the bronchitic syndrome are described. Their mode of action, target, and dose are explained. In practice, physiotherapy should be applied as a complex series of treatment.

Bronchitis↗
PubMed1987

[Status of physical therapy in the treatment strategy of internal diseases].

The use of physiotherapy as traditionally successful form of therapy is not in the least satisfying in practice. The reasons for this are explained. Issuing from a general assessment of the therapy in the system medical care, principal aspects for an interdisciplinary therapy are demonstrated. Essential for a scientifically proved use of physiotherapy is the differentiation between general and specific aspects in the pathologic process made in the general nosology. The effects of the physiotherapy are shown and its significance as basis therapy is emphasized. Apart from the knowledge of the individual physiotherapeutic remedies, the use of the physiotherapy has as its prerequisite a valuation of the pathogenetic factors and actual additional conditions. Corresponding to the therapeutic aim, the physiotherapy should be conceived either as monotherapy or as a long-term, frequently multi-dimensional therapeutic programme. Essential errors in practice are the technically insufficient and inconsequent use of the treatment capacities. With the help of the recommendations for the use of the physiotherapy in the essential hypertension and rheumatoid arthritis ways are indicated how the potencies of the specialty are to be realised better than hitherto done in chronic diseases.

Arthritis, Rheumatoid↗
PubMed1978

[Experiences gained from the establishment of a complex physical therapy program for the management of female urinary incontinence].

Reported in this paper are preliminary experiences so far obtained from a complex physiotherapeutic programme for conservative and pre-operative treatment of functional urinary incontinence in women. Included in this pilot study were 82 patients of whom 23 (28 per cent) were continent on termination of the therapy, while another 38 (46 per cent) had improved to an extent where they abandoned their original intention to undergo surgery for incontinence. Complex physiotherapy may add favourably to the spectrum of possible therapeutic approaches, provided its proper and differentiated coordination with the generally known surgical approaches.

Electric Stimulation Therapy↗
PubMed1975

Simultaneous determination of propranolol and 4-hydroxypropranolol in plasma by mass fragmentography.

A quantitative method for the simultaneous determination of propranolol and its active metabolite 4-hydroxypropranolol in human plasma is described. Plasma samples are extracted at pH 9.6 with ethyl acetate after the addition of sodium bisulphite and the internal standard oxprenolol. The extracts are derivatized with trifluoroacetic anhydride before separation on a gas chromatograph--mass spectrometer. Detection and quantitation of the trifluoroacetyl derivatives are made by single-ion monitoring. The minimum detectable concentration of propranolol is 1 ng/ml and of 4-hydroxypropranolol 5 ng/ml using 1-ml plasma samples. No interferences from normal plasma constituents or from drugs commonly prescribed together with propranolol were detected.

Chromatography, Gas↗
PubMedDate not supplied

[The gait of patients with full weightbearing capacity after hip prosthesis implantation on the treadmill with partial body weight support, during assisted walking and without crutches].

PROBLEM: Treadmill training with partial body weight support is a new promising technique in the rehabilitation in hip arthroplasty patients. With little data on the gait pattern and extent of pelvitrochanteric muscle activation, this study analysed the gait of hip arthroplasty patients walking on the treadmill and also during floor walking with and without crutches. METHOD: Gait analysis in 19 hip arthroplasty patients capable of full weight bearing included the assessment of kinematics, kinetics and kinesiologic electromyogram of relevant trunk and lower limb muscles during treadmill walking with 15% of body weight support, and during floor walking with and without crutches at comparable walking velocities. RESULTS: Both on the treadmill and with crutches, patients walked less frequent, with a longer stride and more symmetric as compared to the unaided gait. Both techniques, however, resulted in a reduced activation of most of the pelvitrochanteric muscles, particularly when using crutches. The comparison of both supporting methods revealed a higher activity of the M. gluteus medius of the affected side on the treadmill. The amount of body weight reduction was comparable ranging from 10 to 15%. CONCLUSIONS: Treadmill training with constant body weight support enables hip arthroplasty patient to entrain a dynamic and symmetric gait pattern with a better activation of the hip abductor of the affected side as compared to walking with crutches. Nevertheless, the level of activation was less than when walking without crutches which, however, resulted in a limping gait pattern.

Aged↗