PubMed Health⌕ Search

Biomedical subjects

E Cristea

Publications and source records attributed to E Cristea.

At least 19 recordsLinked to original sources
PubMed2000

New substituted 2-(pyrazol-1-yl) o-, m-, p-methylacetanilides with potential local anaesthetic and antiarrhythmic action. Part I.

Fifteen substituted 2-(pyrazol-1-yl)acetanilides were synthesized by N-alkylation of pyrazole and some of its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anaesthetic and antiarrhythmic actions. The new compounds have been characterized by elemental chemical analysis, UV-Vis, IR, 1H, 13C NMR spectra and pharmacology research.

Acetanilides↗
PubMed1981

2-4-Dichloro-phenoxy-acetic acid interactions with the detoxification hepatic systems.

The present work has as aim to establish the interaction of 2-4-dichloro-phenoxy-acetic acid with the detoxification hepatic systems. The activation of the mixed function oxidase-system (MFOS) which converts the compound to a powerful arylating agent detoxified by glutathione-S-transferase was observed. The dose used do not overpass the cell adaptive capacity, tested by the serum enzymes activities, tissue lipid peroxides and glutathione concentration.

2,4-Dichlorophenoxyacetic Acid↗