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Biomedical subjects

E Czestochowska

Publications and source records attributed to E Czestochowska.

At least 19 recordsLinked to original sources
PubMed1992

Subcutaneous low molecular weight heparin versus subcutaneous unfractionated heparin in the treatment of deep vein thrombosis: a Polish multicenter trial.

In a prospective multicenter trial, 149 consecutive patients with phlebographically proven proximal and/or distal deep vein thrombosis of the leg were randomly allocated to receive subcutaneously for 10 days either low molecular weight heparin CY 216 (Fraxiparine) in a fixed dose or unfractionated heparin (UFH) in doses adjusted according to the activated partial thromboplastin time. Pre- and post-treatment phlebograms were assessed blindly using the Arnesen's score system in 134 patients available for analysis of the treatment efficacy. The mean phlebographic score after 10 days of treatment was significantly decreased in both groups (p less than 0.001) in comparison with the baseline score but the difference in score changes between the two groups was not statistically significant. There was an improvement in 45/68 patients (66%) in the Fraxiparine group and in 32/66 patients (48%) in the UFH group, and an increase in the thrombus size in 10/68 (15%) and 12/66 (18%), respectively. One symptomatic non-fatal pulmonary embolism and one major bleeding episode were observed in the UFH group. During a follow-up period of 3 months, two rethromboses had occurred in the UFH group and none in the Fraxiparine group. It is concluded that subcutaneous fixed dose Fraxiparine is safe and at least as effective as subcutaneous adjusted UFH in the treatment of deep vein thrombosis.

Adult↗
PubMed1990

Effect of nitrox saturation diving upon platelet hemostasis.

Two nitrox saturation exposures (seven- and nine-days) at a pressure equivalent to 40 and 45 m (pO2 40-50 kPa) with three divers were carried out. During one exposure 6 excursions from the plateau to the depth of 70 m (one hour) and 60 m (four hours) were made. Before and after the exposures blood platelet count, aggregation and adhesion of blood cells were determined. After the first series of diving a slight increase of adhesion and aggregation was observed, after the other one, despite the larger depth and the excursions from the saturation plateau to 60 and 70 m, a slight decrease of adhesion occurred. This allows to conclude that the phenomenon is related to the decompression load degree as well as to the condition of the divers. Finding about the effect of decompression upon the processes of hemostasis may be useful for the evaluation of the verified system of saturation decompression.

Decompression↗
PubMed1987

Disturbances of platelet function in patients with multiple myeloma.

Coagulation disturbances in patients with multiple myeloma are presented. Platelet disfunction was especially observed, but only in patients with marked hyperproteinemia and a high level of immunoglobulins in plasma, whereas normal adhesion and aggregation were noticed in 3 out of 17 patients without protein disturbances. Chemotherapy as well as plasma exchange caused not only a decrease of the paraprotein level in plasma, but also a normalization of the failure previously observed in platelet function. Our experiments confirm the opinion that protein M in plasma is responsible for the disturbances observed in multiple myeloma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

Clinical investigations on long-term activation of fibrinolysis by anabolic steroids.

The influence of anabolic steroids plus phenformin on the course of disease was studied in patients suffering from occlusive vascular diseases. In arteriosclerosis obliterans of the lower limbs the combined therapy led to a higher percentage of improvement than the control group showed. In coronary heart disease there was also a beneficial effect of this treatment. The drugs were found to exert beneficial clinical effects especially in patients with thrombophlebitis migrans and superficial thrombophlebitis. From the results of this study it is concluded that this therapy may be of clinical value in the treatment of patients with occlusive vascular diseases.

Adult↗
PubMed1985

A case of congenital factor XIII deficiency.

The case of a 53 years old woman was described in whom a congenital factor XIII deficiency was suspected because of deforming scars and hemorrhagic diathesis. A thromboelastographic declination of elasticity as well as decreased factor XIII level up to 5% of normal range were only found in all hemostatic examinations. In 2 children factor XIII decreased to half of its normal level, whereas in the youngest daughter that level was 25%. Sporadically the girl had mild diathesis. No changes in thromboelastograms were observed in members of the patient's family. The platelet function was unchanged in all examined cases.

Factor XIII Deficiency↗
PubMed1979

[Adenomectomy in hemophilia A patients].

A patient with haemophilia A is described in whom a loading blood-loss after adenomectomy developed. The congenital haemorrhagical diathesis was diagnosed only after the surgical intervention, since there did not exist any clinical symptoms. Taking into consideration world literature the problem of adenomectomy in patients with haemophilic is discussed.

Aged↗