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Biomedical subjects

E D Goldsmith

Publications and source records attributed to E D Goldsmith.

6 recordsLinked to original sources
PubMed1979

The effects of aminotriazole (ATZ) on the thyroid gland and the development of the White Leghorn chick.

White Leghorn chicks, injected i.p. (days 3 through 40) with 0.5 g/kg or 1.0 g/kg mean body weight of aminotriazole (ATZ), gained less weight than the control animals. In the 1.0 g/kg ATZ group in comparison to the 0.5 g/kg animals, the responses were of greater magnitude and for longer durations of time. In both experimental groups, the thyroid/body weight ratios increased and were greater than those of the controls after day 10. In the higher dosage group, these ratios increased markedly, whereas with the lower dosage group, the ratios stabilized at a lower value. Histological alterations of the thyroid included hypertrophy, hyperplasia and hyperemia. To study the effect of cessation of drug treatment, groups of animals received the same dosages of ATZ through day 20. At the termination of the experiment (day 41), this resulted in a sharp increase in body weight, experimentals weighing as much as or more than the controls. Regarding the decrease in thyroid/body weight ratios, experimentals never attained the low control values. However, upon cessation of drug treatment, a return towards normal thyroid histology was noted. The gross body weight, the thyroid/body weight ratios, the histological analyses of the thyroidal components and the triiodothyronine and thyroxine determinations in the blood serum demonstrate that ATZ is a potent goitrogenic agent which produces a state of functional hypothyroidism.

Amitrole↗
PubMed1977

A histochemical study of aldehyde fuchsin-positive material and "high-esterase cells" in the pineal gland of the Mongolian gerbil.

The pineal gland of the Mongolian gerbil consists of a superficial gland, stalk and deep pineal. The deep pineal differentiates postnatally. Histochemical studies of the superficial pineal gland indicate that it may be involved in the secretion of protein. Presumptive secretory material visualized by aldehyde fuchsin (AF) and chrome hematoxylin was observed along the course of blood vessels and among the pinealocytes. The distribution and texture of the AF-positive material was distinctive. It did not correspond to the pattern and texture of material stained with PAS, Sudan Black or acid orcein. Staining with AF was markedly reduced after incubation with trypsin, indicating that the AF-positive material is at least partially protein. The amount of stainable material increased with age. The AF-positive material was observed in what appeared to be interstitial or glial cells and processes, and in the processes of perivascular cells. Cells and fibrous processes with high non-specific esterase activity ("high-esterase cells") were observed among the pinealocytes and along the course of blood vessels. The distribution of the "high-esterase cells" and the morphology and texture of their esterase-containing processes were remarkably similar to the morphology and distribution of the material that stained with AF. It may be that the "high-esterase cells" contain AF-positive material. The "high-esterase cells" hydrolyzed both alpha-naphthyl acetate and alpha-naphthyl butyrate. The pinealocytes hydrolyzed only alpha-naphthyl acetate. The "high-esterase cells" appear to form a distinct class of cells within the superficial pineal gland. They are tentatively identified as a type of glial cell.

Acid Phosphatase↗
PubMed1976

Calcified inclusions in the superficial pineal gland of the mongolian gerbil, Meriones unguiculatus.

A histological and histochemical study of the pineal gland of neonatal, juvenile and adult gerbils is described. Calcified inclusions appear within pinealocytes in the superficial pineal about the third week of age, and the incidence of inclusions increased with age until, by the eleventh week, they are found in all animals. The inclusions contain an organic matrix composed of a carbohydrate, probably an acid mucopolysaccharide, complexed to protein. Calcification does not occur in the deep pineal. The data are interpreted to indicate that the formation of calcified inclusions is a normal process within the gerbil pineal. The similarity of the process of calcification in the gerbil and in the human pineal suggests that the gerbil may be an animal of choice for the controlled study of the phenomenon of pineal calcification.

Age Factors↗