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Biomedical subjects

E D Holyoke

Publications and source records attributed to E D Holyoke.

At least 91 records · Page 5Linked to original sources
PubMed1975

The clinical implications of a staging system for carcinoma of the anus.

During the past 20 years, several treatment regimens have been proposed for the management of squamous cell carcinoma of the anus. Our results confirm the general impression that a wide abdominoperineal resection is the treatment of choice, although some good results have been obtained with the use of radium implants and megavoltage radiotherapy in isolated instances. In our series, two patients survived nine years with this form of treatment. To dissipate much of the confusion that surrounds the terminology of those tumors arising in the anal region, we concur with Morson's suggestion that they should be designated as keratinizing and nonkeratinizing. There was no statistically difference in survival rate between tumors arising in the anal canal and in the perianal skin. The importance of delimitating the extent of the disease, before any form of treatment is attempted, has been emphasized, and our staging system has been presented. Finally, the question concerning the management of inguinal node metastases has been further developed with special emphasis on their different significance whether they appear early or late in the course of the disease.

Adult↗
PubMed1975

Endoscopy in patients with malignant conditions of the gastrointestinal tract.

Two hundred and fifteen consecutive upper gastrointestinal endoscopies were performed. It is evident that the patient population in our setting is quite different when compared with that of a general hospital. The incidence of both gastrointestinal hemorrhage and unknown primary malignant tumor is high. In this group of patients, malignant lesions of the stomach were the most common problem encountered. Primary malignant tumors of the stomach account for the diagnoses in approximately 20 per cent of our patients. Fifty per cent of the patients with cancer of the stomach demonstrated invasion of the lower part of the esophagus or esophagogastric junctional area. The accuracy of endoscopic biopsy was correct in 83 per cent of the patients with malignant tumors of the stomach detected by scopic examination. Thirteen per cent false-negative biopsies occurred from infiltrating diffuse lesions. Endoscopy established the diagnosis of carcinoma of the stomach in one-third of the patients with adenocarcinoma of unknown primary source.

Adenocarcinoma↗