Long-term use of minidose heparin in post-myocardial infarction.
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Female↗
Biomedical subjects
E D Johnson
Publications and source records attributed to E D Johnson.
Immune responses to LCM virus infection in vivo and in vitro. Mechanisms of immune-mediated disease.
Both recovery and death of mice following acute infections with lymphocytic choriomeningitis virus appear to be mediated by a population of virus-specific thymus-derived (T) effector lymphocytes that possess lytic activity in vitro against virus-infected syngeneic fibroblasts. Whether recovery or death occurs is determined by the balance between two interdependent factors: (1) the extent of virus-induced modifications in the surfaces of cells comprising "target" tissues, and (2) the efficiency of the immune inductive process leading to the generation of effector T lymphocytes that recognize and destroy these modified cells.
Animals↗
Haemorrhagic fever virus activity in equatorial Africa: distribution and prevalence of filovirus reactive antibody in the Central African Republic.
Seroepidemiological surveys were conducted to determine the frequency and distribution of haemorrhagic fever virus (HFV) activity in the Central African Republic. Human serum specimens (4295) were collected from 5 ecologically distinct zones. Serological evidence of HFV activity was found in all the zones. The filovirus antibody prevalence (24.4%, 1051/4295) was greater than the combined prevalence for Lassa virus, Rift Valley fever virus and Crimean-Congo HFV antibody (1.1%, 45/4295; P < 0.01). Evidence of filovirus activity was found in all zones: 21.3% (914/4295) of the population were seropositive for Ebola virus antibody while only 3.2% (137/4295) were seroreactive with Marburg viral antigens. Age and sex were important host-related factors influencing filovirus activity, particularly in dry grassland and moist forest communities. These communities shared many factors, but differences, such as agricultural practices and ethnic backgrounds, may also affect the risk of infection. Filovirus infections appear to occur without apparent disease. Continued investigations are needed to evaluate the true pathogenicity of the African filoviruses and the likelihood that unidentified serologically cross-reacting and non-pathogenic members of the filovirus family are active in equatorial Africa.
Adolescent↗
Filovirus activity among selected ethnic groups inhabiting the tropical forest of equatorial Africa.
Seroepidemiological surveys were conducted to determine the frequency and distribution of filovirus activity among selected ethnic groups inhabiting the tropical forests of the Central African Republic. 427 serum specimens were collected from hunter-gatherers and subsistence farmers living in forest environs in the Lobaye District south of the river Lobaye and west of the river Oubangui. Striking serological evidence for filovirus activity was found in both populations. Ebola virus appears to be the most active filovirus; 17.6% (75/427) of the Lobaye survey population were seropositive for Ebola virus reactive antibody while 1.2% (5/427) were seroreactive with Marburg viral antigens. Ethnic background appeared to be an important risk factor influencing filovirus exposure in the forest communities. The filovirus antibody prevalence among 21-40 years old male Aka Pygmy hunter-gatherers was significantly (P = 0.03) 3 times higher (37.5%) than that in similarly aged male Monzombo and Mbati subsistence farmers (13.2%). Continued epidemiological investigations are needed to define ethnic-related events influencing human filovirus activity in the Congo basin of equatorial Africa.
Adolescent↗
Antibody prevalence against haemorrhagic fever viruses in randomized representative Central African populations.
Between 1985 and 1987, 5,070 randomly selected persons living in 6 central African countries (Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea and Gabon) were checked for serological evidence of haemorrhagic fever. Rural and urban areas were studied, including ecoclimatic zones ranging from dry savana to tropical rain forest. Virus-reactive antibodies were found with all antigens tested, and the global prevalence of positive sera was distributed as follows: Crimean-Congo haemorrhagic fever virus, 0.22%; Rift Valley fever virus, 0.18%; Ebola virus, 12.40%; Marburg virus, 0.39%; Lassa virus, 0.06%; and Hantaan virus, 6.15%. A significant variation in antibody prevalence was observed within the study regions. Association between the viruses was not observed.
Africa, Central↗
The assessment of insulin, glucose and lipids in ischemic thrombotic cerebrovascular disease.
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Aged↗
Some benchmark searches for testing search capabilities and medical coverage of internet discovery tools.
The past few years have seen a proliferation of search engines for the World Wide Web (WWW), as well as a growing number of specialized subject directories geared to the needs of health care professionals. Yet documentation on scope, coverage, and search features is often uneven at best; and even documented search features may not perform as advertised. This paper will present a group of sample searches to assist users in gauging database size, determining default search operators, and testing for the presence of advanced search features such as case sensitivity, stemming, and concept mapping for medical topics on English-language web sites.
Databases, Factual↗
Thumb-sucking: literature review.
A multidisciplinary literature review of nonnutritive-sucking habits is presented. The causes, prevalence, and risks of these habits are discussed, and factors that contribute to the severity of the habit are identified.
Child↗
Thumb-sucking: classification and treatment.
A new classification and treatment scheme is described that allows practitioners easy classification and appropriate treatment of a wide variety of nonnutritive-sucking habits. Summary classification and treatment reference tables are provided for convenient clinical reference.
Awareness↗