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Biomedical subjects

E D Wolf

Publications and source records attributed to E D Wolf.

12 recordsLinked to original sources
PubMed1991

Treatment of epibulbar melanocytoma in a dog, using full-thickness eyewall resection and synthetic graft.

A limbal, epibulbar melanocytoma was treated by use of a full-thickness eyewall resection. The resulting defect was repaired by use of a synthetic graft of polytetrafluoroethylene. The graft remained in place for 7 weeks and was well tolerated, but failed to be incorporated by the surrounding tissues. New, healthy tissue did grow beneath the graft and allowed the graft to be surgically removed at 7 weeks.

Animals↗
PubMed1991

Spontaneous ophthalmic lesions in young Sprague-Dawley rats.

Eight hundred eight Sprague-Dawley rats were examined for ophthalmic abnormalities during a pretest period in various preclinical safety assessment studies. Persistent pupillary membrane, corneal crystal, healed minor trauma, synechia, coloboma of the iris, lens luxation, cataract, persistent hyperplastic primary vitreous, vitreous hemorrhage, coloboma of the optic disc or choroid, remnant of hyaloid arterial system, retinal hemorrhage, retinal detachment, retinal folding and choroidal defect were observed. The incidences of corneal crystal, synechia, and nuclear cataract in this survey were higher than those reported previously. On the other hand, retinal folding in this survey was less common than that reported previously. These results suggest that background data of eye problems in albino rats should be accumulated in each own laboratory colony. In addition, since spontaneous eye problems are common in young albino rats, elimination of rats with ophthalmic abnormalities from study groups by an ophthalmic examination during a pretest period would facilitate to evaluate toxicity potential of test compounds in safety assessment studies.

Animals↗
PubMed1989

Treatment of serous retinal detachments associated with optic disk pits in dogs.

Serous retinal detachment, associated with optic disk pit, was diagnosed in 28 eyes of 24 dogs. Xenon arc photocoagulation was used in treatment of the detachment. Of 24 dogs, 21 were Collies. In 23 eyes, retinal detachments affected temporal and/or inferior portions of the retina. In 5 eyes, detachments were predominantly superior and/or nasal. A single photocoagulation treatment resulted in reattachments in 25 eyes. Of the 3 remaining detachments, 2 eyes improved with additional photocoagulation, and 1 eye, which was not treated further, had a complete retinal detachment.

Animals↗
PubMed1989

Efficacy of zinc citrate ascorbate for treatment of canine cataracts.

Efficacy of zinc citrate ascorbate was evaluated in 146 dogs (265 eyes) that had various lens opacities. Zinc citrate ascorbate or saline placebo drops were applied topically once or twice daily for 4 to 31 weeks. Of 138 eyes treated with zinc citrate ascorbate, 86 eyes (62.3%) had no change, 48 eyes (34.8%) had increased lens opacity, and 4 eyes (2.9%) had decreased lens opacity. Of 127 eyes treated with a saline placebo, 99 eyes (77.9%) had no change, 25 eyes (19.7%) had increased lens opacity, and 3 eyes (2.4%) had decreased lens opacity. Zinc citrate ascorbate drops were not significantly (P = less than 0.05) more effective in clearing cataracts than were saline drops. Seemingly, zinc citrate ascorbate drops may have caused lens opacities to increase in area and density.

Animals↗
PubMed1978

Rod-cone dysplasia in the collie.

Rod-cone dysplasia in the Collie was studied. Night blindness developed early (6 wk) and progressed to nearly total blindness by 1 year of age. Tapetal hyper-reflectivity, vessel attenuation, and optic nerve pallor were clinically evident by 6 months of age. Electroretinography demonstrated markedly reduced retinal response as early as 16 days of age. The results of selective breedings conformed to a single recessive pattern of inheritance.

Animals↗
PubMed1975

Ophthalmic manifestations of induced sickling of erythrocytes in Japanese sika deer (Cervus nippon).

Nine female Japanese sika deer (Cervus nippon) were used in a total of 25 experiments in which sickling was chemically induced. During these experiments, color fundic and color fluorescein photographs were taken. Fundic changes included retinal vascular attenuation, blood column pallor, and decreased tapetal reflectivity. These changes were most likely directly associated with a decreased hematocrit and a generalized shocklike condition. Three deer had a congested appearance in retinal blood vessels and tapetum lucidum. Two of the 3 deer developed serous detachment of the retina. These changes seemingly were associated with severe venous statis; all 3 deer died shortly after the experiment was terminated. These experiments yielded data only for the acutely affected deer. None of the ocular changes could be considered the result of chronic sickling because of the reversal of sickling that occurred despite continued intravenous administration of bicarbonate. None of the deer developed ocular changes characteristic of sickle cell retinopathy in human beings. The changes in human beings probably result from continued stress and prolongation of sickling, and especially from a multiplicity of repeated severe episodes of sickling occurring over many years.

Alkalosis↗
PubMed1975

In vivo erythrocyte sickling in the Japanese sika deer (Cervus nippon): methodology.

The Japanese sika deep (Cervus nippon) proved to be a suitable animal model for the study of acute phases of in vivo erythrocyte sickling. Ophthalmologic studies can be conducted during or after 1 to 6 hours of effective in vivo sickling. Intravenous administration of 1.75 to 3.5% sodium bicarbonate solution at a rate of 500 to 1,000 ml per hour produced a transient state of alkalosis and in vivo erythrocyte sickling in the sika deer. The percentage of sickled erythrocytes increased as the blood pH increased. Concurrently, the packed cell volume decreased. Sickling was enhanced by 100% oxygen ventilation after endotracheal intubation and light anesthetization. After the induction of erythrocyte sickling, a sickling-reversal phenomenon occurred despite continued bicarbonate administration. During the course of this reversal, the percentage of sickled erythrocytes steadily decreased, the venous blood pH decreased, and the packed cell volume slowly increased. Because of the sickling-reversal phenomenon, chronic erythrocyte sickling was not achieved.

Alkalosis↗
PubMedDate not supplied

Cone-rod dystrophy in the Guinea baboon.

Three stages of macular degeneration associated with diffuse cone-rod dystrophy have been described in a Guinea baboon (P papio) colony. Clinically, the affected animals displayed abnormal behavior associated with decreased vision. Ophthalmoscopically, the lesion in the macula was the only change observable in early cases; retinal vessel attenuation and optic disc pallor were seen only in the advanced cases. The hyperfluorescence of the maculae was the result of loss of pigment in the pigmented epithelium. Electrophysiology supported a cone-rod sequence of this retinal dystrophy. Histologic examination confirmed the theory that the dystrophy began in the cone outer segment but eventually involved all the photoreceptors.

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