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Biomedical subjects

E Dale

Publications and source records attributed to E Dale.

9 recordsLinked to original sources

An evaluated programme of rheumatology training for general practitioners.

The management of painful, upper-limb disorders by 34 general practitioners (GPs) was examined 3 months before and 3 months after personal instruction of GPs by a consultant rheumatologist. Tuition was conducted either in GP surgeries or a hospital out-patient department. Following instruction there were significant increases in the application of appropriate treatments (p less than 0.0005) and of local corticosteroid injections by GPs (p less than 0.005), fewer requests for investigations and less-frequent hospital referrals for consultant rheumatology opinions. Hospital out-patient instruction was associated with a significant reduction of patients' time off work (p less than 0.005) and, in general, differences of management appeared to be more pronounced amongst those GPs instructed in the hospital than in GP surgeries. The study showed that personal instruction of GPs by a consultant rheumatologist may result in modifications of practice, at least in the short term. The evidence indicates that such alterations of GP management may significantly reduce patient morbidity.

Arm

Some considerations of exercise during pregnancy.

In this review the physiologic responses to exercise during pregnancy and the outcome of pregnancies from studies of animal models and human subjects are presented. Based on the clinical concerns about exercise participation during pregnancy and the studies presented herein, certain recommendations for an exercise program for the pregnant woman are given.

Adult

Menstrual dysfunction in distance runners.

The problem of menstrual dysfunction in women who engage in endurance training for participation in distance running events has been studied. Through survey, selected aspects of the personal, training, menstrual, and contraceptive histories of 168 women who were defined as runners, joggers, or controls were evaluated. In addition, defined subsets of the study subjects were evaluated for serum levels of pituitary and ovarian hormones and determination of percentage body fat. The data show significant differences among the 3 groups. It is concluded that menstrual dysfunction in distance runners is a real phenomenon. Presumably this is related to decreased percentage of body fat and/or minimal ovarian function secondary to diminished hypothalamic or pituitary hormone secretion.

Adipose Tissue

A direct radioimmunoassay for estriol-16alpha-glucosiduronate: its use in the determination of plasma and urine levels and renal clearance of this conjugate in pregnancy.

A direct radioimmunoassay which does not require hydrolysis or chromatography has been developed for estriol-16alpha-glucosiduronate in pregnancy plasma and urine. The antigen used in the development of this antiserum was prepared by joining the carboxylic acid group of estriol-16alpha-glucosiduronate covalently to the epsilon-amino group of the lysine residues in bovine serum albumin. Results indicate that the direct radioimmunoassay yields levels of estriol-16alpha-glucosiduronate in late pregnancy urine that are comparable to those obtained by mroe elaborate procedures involving chromatographic separation of the estriol conjugates, followed by enzymic hydrolysis and measurement of the freed estriol. In addition, good correlation was found between the total estrogen values in urine obtained by currently used chemical procedures and urinary levels of estriol-16alpha-glucosiduronate. The renal clearance of estriol-16alpha-glucosiduronate was determined in eight normal women during the third trimester, and the mean value +/- S.D. was 404 +/- 81 ml. per minute (range, 248 to 494). This method is suitable for the evaluation of variations in the plasma and urine levels of estriol-16alpha-glucosiduronate in pregnancy and offers significant advantages over the presently used chemical methods for monitoring fetal well-being.

Animals

Limitations in prediction of gestational age and birth weight by ultrasonographic methods.

The index of predictability of estimated gestational age (EGA) and birth weight (BW) from biparietal diameter (BPD) was tested in 1333 normal pregnancies; 96% of the patients were black. The correlation BPD and actual weeks to delivery was 0.834, r2 =69.5%. Confidence limits were established and a nomogram for EGA was derived. Our nomogram and two similar ones were compared. The overall correlation between them was good, but that for specific BPD and EGA was not. In addition, our BPD values were smaller for corresponding gestational ages in other nomograms. The overall accuracy of estimated delivery date was +/- 1.6 weeks. We were not able to predict birth weight at all from a single, random BPD measurement. We have demonstrated the serious limitations that exist in the prediction of gestational age from previously established nomograms. We infer that this error is even greater when homogenous populations are so studied. We suggest that any published BPD-EGA or BPD-BW nomogram be given close, intensive statistical scrutiny, within the population studied, before it is used. When such scrutiny is not possible, serial sonographic determinations, or longitudinal use of growth charts, would be more acceptable.

Adolescent

Plasma concentrations of connective tissue compounds: I. the effect of uterine involution.

The information obtained in a prospective study of plasma concentrations of connective tissue components during the third trimester of pregnancy, 4 days, and again at 6 weeks postpartum, suggests that the increased concentrations of plasma protein-hydroxyproline (hypro-protein), free proline, and GAG are associated with increased rate of hydrolysis of extraskeletal connective tissue components.

Adolescent

The surgical management of invasive cancer of the cervix in pregnancy.

During a 13 year period ending in July, 1974, 42 obstetric patients with a diagnosis of invasive carcinoma of the cervix were seen. Nine patients were treated with primary radiation therapy; 33 patients were treated with primary surgery. Total hysterectomy with partial vaginectomy was performed in seven patients with Stage I-A, and extensive abdominal hysterectomy with bilateral pelvic lymphadenectomy was performed in 26 patients (14 with Stage I-A, nine with Stage I-B, and three with Stage II-A). Thirty-eight patients are alive and well from three months to 13 years following treatment. Extensive abdominal hysterectomy and pelvic lymphadenectomy can be done in selected obstetric patients with invasive carcinoma of the cervix with an acceptable morbidity and cure rate. Normal ovaries left in place will continue to function normally. Seven patients with a conization diagnosis of Stage I-A had a planned delay in definitive treatment until delivery at term.

Adenocarcinoma