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Biomedical subjects

E De Grazia

Publications and source records attributed to E De Grazia.

At least 19 recordsLinked to original sources

[Enuresis in children. Diagnostic assessment and treatment].

Many theories on the etiology of enuresis have been suggested, including psychogenic, structural abnormalities, dysfunctional aspects. The study consisted of 95 children with primary enuresis (35 girls, 60 boys). 58% of patients presented with enuresis plus evidence of voiding dysfunction. Patients with pure nocturnal enuresis were 17%. 42% of children have normal bladder on urodynamic testing. Anticholinergic medication was effective in children with voiding dysfunction. The base line treatment program, in children with normal urodynamic studies, included psychotherapy, medications, bladder training. Authors present their experience and results of treatment. The usefulness of urodynamic assessment in children with only nocturnal enuresis is discussed.

Adolescent

Epididymo-testicular anomalies in the undescended testis. How important is their effect on infertility?

Infertility in subjects affected by undesceded testis occurs in from 25 to 100% of the cases according to the various Authors. This depends on whether one or both gonads are concerned and on the age when medical and/or surgical treatment of the condition was begun. Our study was made in two successive periods: first we studied the secretory causes of infertility by examining some histological parameters, (MTD, IFT), and endocrinological ones, (basal testosterone and then after HCG, basal gonadotropin and then after GnRH) in 43 subjects of ages ranging between 2 and 13 years who are affected by uni- or bilateral maldescension. We then analysed the excretory causes of infertility and classified and interpreted 108 epididymo-testicular malformations out of a total of 144 undescended testis observed during our last year of work. We conclude that from a histological point of view, from the third year after birth there is a steady progressive reduction in the tubular fertility index in undescended testis compared to scrotal testis. There is no significant reduction, however, in the mean tubular diameter up to the prepubertal phase. From the endocrinological point of view, we found a normal LH secretion and hypertonia in the pituitary secretion of FSH in bilateral maldescension, not found, however, in unilateral maldescension. Finally, anomalies concerning the epididymo-testicular relationship are found in 75% of undescended testis and of these 36% have a definite effect on infertility of the excretory type.

Cryptorchidism

[Flowmetric changes induced by glucagon in the mesenteric artery region during experimental hemorrhagic shock in dogs].

The pharmacological action of glucagon in the regulation of systemic and mesenteric district haemodynamics, in line with the approach that has come to the fore in recent years for treating haemorrhagic shock with vasodilators, suggested a study of the effects of glucagon on mesenteric haemodynamics during haemorhagic shock in dogs. It was shown that the infusion of glucagon increases mesenteric arterial flow and peripheral resistances are reduced without particular systemic modifications.

Animals

[Experimental evaluation of mesenteric flowmetric changes induced by eating and digestion under normal conditions and after vagotomy and gastric resection].

Reference is made to recent data concerning the regulation of mesenteric haemodynamics by enteric hormones. Changes in mesenteric circulation in the course of altered intestinal hormonal secretion were examined. The results showed that a real connection exists between such secretion and the regulation of mesenteric haemodynamics, since flowmeter changes were noted after surgical operations performed on experimental animals.

Animals