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Biomedical subjects

E De Micheli

Publications and source records attributed to E De Micheli.

5 recordsLinked to original sources

Edge-detection schemes highly suitable for hardware implementation.

Two schemes for edge detection of real images based on gradient maxima are presented. Images are filtered with narrow filters to increase localization. Experimental results and theoretical considerations suggest that the exact shape of the filter is not critical for good performance of the algorithm. Therefore a filter can be chosen to allow for a highly efficient hardware implementation, for example, a binary filter or a 4-bit finite-impulse-response filter. Because the digitized values of a binary filter are powers of 2, the hardware implementation does not require time-consuming computations, such as multiplication and time shift, but just appropriate addressings. The performance of this scheme, or a similar scheme using 4-bit filters, is as satisfactory as that of more sophisticated schemes. Therefore these low-cost schemes are likely to be more suitable for hardware implementation.

Algorithms

Age-dependent cerebral metabolic effects of unilateral nucleus basalis magnocellularis ablation in rats.

To investigate the age-dependent functional importance of cholinergic neocortical inputs, and to explore whether cortical cholinergic denervation in aged animals might better model the cerebral metabolic changes of Alzheimer's disease, the effects of unilateral ablation of the nucleus basalis magnocellularis (NBM) on cerebral glucose metabolism were studied in young and aged rats. Regional cerebral metabolic rates for glucose (rCMRglc) were determined, using the [14C]deoxyglucose method, in 48 brain regions of 3- and 24-month old Fischer-344 rats at 3, 7, 14 and 28 days after stereotaxic injection of ibotenate into the right NBM, and in sham-operated animals at 3 and 14 days later. For both ages the peak effect of unilateral NBM ablation occurred 3 days later: in young rats, rCMRglc was significantly reduced (compared to the contralateral side) in all 24 anterior cortical areas examined (mean decline 20%), whereas in aged animals, only 9 of 24 areas showed a significant decline in glucose utilization, and the magnitude of rCMRglc reduction (9%) was smaller. Near complete recovery of rCMRglc occurred by 7 days in young and old rats. We conclude that the basalocortical cholinergic projection plays a smaller role in neocortical function of aged rats, possibly because its tonic activity is reduced. Both young and aged rats undergo cortical metabolic normalization after unilateral NBM ablation; hence the NBM-lesioned aged rat is not a better model of the progressive decline in rCMRglc that occurs in Alzheimer's disease.

Acetylcholinesterase

Effects of flunitrazepam on local cerebral glucose utilization in the rat brain.

Flunitrazepam effects on local cerebral glucose utilization in the rat brain were investigated with the (14C) 2-Deoxy-D-Glucose procedure. The drug decreased glucose utilization in many areas of the rat brain, whereas no increases were observed. In this respect, the metabolic effects of flunitrazepam were different from those of other CNS "depressant" drugs, such as isoflurane and phencyclidine. Compared to the metabolic changes induced by diazepam, flunitrazepam peak effects appeared later and involved a greater number of regions.

Animals