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Biomedical subjects

E De Seta

Publications and source records attributed to E De Seta.

17 recordsLinked to original sources
PubMed2006

Extramedullary plasmacytoma of paranasal sinuses. A combined therapeutic strategy.

Extramedullary plasmacytoma of the head and neck region is a rare malignant tumour comprising approximately 3% of all plasma cell tumours. Approximately 80-90% of extramedullary plasmacytomas involve the Mucosa-Associated Lymphoid Tissue of the upper airways, 75% of these involve the nasal and paranasal regions. Radiotherapy is considered the treatment of choice, surgery being limited to biopsy and to excision of residual disease. A case of extramedullary plasmacytoma of the nasal cavity and ethmoid sinus is reported, in which surgical excision is followed by complementary radiotherapy on the site of the tumour.

Aged↗
PubMed2002

Video-based system for intraoperative facial nerve monitoring: comparison with electromyography.

OBJECTIVE: To validate a recently developed intraoperative facial nerve monitoring system that is based on video control of facial movements. STUDY DESIGN: In a single-subject design study, involving 15 otoneurosurgical patients, the relationship between intensity of neural stimulation, facial movements, and electrophysiologic voltage were measured. The analysis was performed by measuring the ipsilateral oral commissure displacement in relation to different levels of current administered to the nerve during surgical procedures. SETTING: Electromyography and video system intraoperative facial nerve monitoring. PATIENTS: 15 patients (9 men, 6 women; mean age, 61 yr) undergoing a translabyrinthine approach for removal of acoustic neuroma. RESULTS: Electromyography showed slightly greater sensitivity. With regard to the stimulation-response ratio, facial movement and electromyographic amplitude showed very similar responses. CONCLUSIONS: The video system was considered useful in terms of validity and reliability. Furthermore, the authors' surgical experience showed some limitations of electromyography, especially in terms of electrical artifact during cauterization, totally masking the electrophysiologic monitoring.

Electric Stimulation↗
PubMed2000

Intraoperative videomonitoring of the facial nerve.

OBJECTIVE: To propose the application of an intraoperative videomonitoring system in otologic and otoneurologic surgery. The authors also compare results obtained by using this system with findings deriving from electromyography and pneumosensorial monitoring methods. STUDY DESIGN: The single-subject design study, involving six patients with middle ear or otoneurosurgery, compares reliability of different monitoring procedures, especially in terms of advantages and drawbacks. SETTING: Video system versus electrophysiologic and pneumosensorial systems. PATIENTS: Two patients affected with chronic otitis media, two from Meniere's disease, and two from Acoustic Neuroma. INTERVENTIONS: Intraoperative diagnostic and prognostic. RESULTS: Electrophysiologic method shows more sensibility, but is affected by a moderate grade of false positive because of electric artifacts; videomonitoring system showed less sensibility, but appears reliable; pneumosensorial system gives in-between results. CONCLUSIONS: In intraoperative monitoring techniques, reliability and feasibility are the most important factors and are achieved, in this study, by the videomonitorig system. Video recording of images have permitted further off-line analysis.

Adult↗
PubMed1993

Initial experience of peroperative electrocochleography monitoring in stapedectomy.

Clinical experience of intraoperative ECochG monitoring during stapes surgery is reported. Selected surgical phases have been taken into consideration, laying particular stress on the phase corresponding to the opening of the labyrinthine spaces. Compound action potential (CAP) amplitude and latency showed, a supposed, an inversely proportional relationship in most of the cases. Abnormal findings were also recorded in some patients, thus giving rise to different electrophysiological hypotheses. A proposal for an "in vivo" model for the study of the electrophysiological changes due to the opening of labyrinthine spaces is made.

Adult↗
PubMed1988

High-frequency audiometry in children.

On the grounds of recent literature and of their own previous studies, the authors have examined a group of 25 normal-hearing children, ranging from 7 to 10 years of age, with high-frequency audiometry. The results were compared with those obtained in a group of young adults. On the basis of these findings, average threshold values were derived for this age group; such data have not yet been published for this simple headset technique. Furthermore, the comparison between the two age groups enabled the authors to determine a deterioration of the high-frequency hearing threshold which takes place at a fairly early age. Reliability of the equipment, in which headphones were used as transducers, was checked and the reproducibility for this test was shown to be adequate, as seen from the low test-retest variability.

Adolescent↗
PubMed1985

High-frequency audiometry above 8 kHz. Comparative results of normative thresholds obtained with a headphone system and a quasi-free-field system.

Since a standard method for high-frequency audiometry does not yet exist, the authors, using 20 young subjects, compare the results obtained with a quasi-free-field system devised by Osterhammel et al. [Scand. Audiol. 6:91-95, 1977] and those obtained by a headphone system. The headphone system is considered to be better, because it offers many practical advantages.

Adult↗
PubMed1984

'Quasi free-field' audiometry: proposal for a modified transducer system.

The authors studied a group of 13 young adults by using high-frequency techniques in 'quasi free-field' conditions, as suggested by Osterhammel, and comparing the results with those obtained by means of an original method suggested by the present study group. The data relative to this last-mentioned technique confirmed it as being valid on the grounds of test-retest findings and standard deviation. It is concluded that both methods are equally effective for the study of the physiology of the ear, but that the present method is less practical from the clinical point of view.

Adult↗
PubMed1977

Eustachian tube permeability during the nasal provocation test.

The results of manometric study on the permeability of the Eustachian tube after a crisis has been produced by exposing 26 cases of perennial nasal atopy to the threshold-dose of the responsible allergen are reported. In 73% of the cases a reduction of the permeability (16 cases) or a stenosis (4 cases) of the ipsilateral tube were found. The importance of inquiring and specifically treating a nasal allergy in patients suffering from secretory otitis is underlined.

Administration, Intranasal↗
PubMed1975

Rhino-rheo-manometric (R.R.M.) nasal provocation test.

The nasal provocation test--which has been considered till now too much time-consuming and troublesome for the patient--becomes rapid and simple by the use of the rhino-rheo-manometry. It is possible, by this method, to evaluate the conductance of a single nasal fossa and its reduction after allergen challenge. The results of test performed in patients suffering from extrinsic perennial nasal atopy by Dermatophagoides pt. have proved that the test becomes rapid and not troublesome by using the rhino-rheo-manometry. This method, giving a provocation threshold, may be used both in diagnosis and control of specific immunotherapy.

Antigen-Antibody Reactions↗
PubMedDate not supplied

Experiences in the determination of nasal mucociliary transport time.

This study is an attempt to establish the most suitable inert substance and normal parameters for nasal mucociliary transport time in normal adults: 79 subjects were taken into consideration, aged between 19 and 74 years, and were selected on the basis of negative outcome to anterior and posterior rhinoscopy , absence of any recent manifestation of rhinopharyngeal pathology and absence of allergy. The authors examined the possible modification of this particular index of nasal function in relation to the position of the head, when inclined or erect, to physical stress and to the hour at which the trials were carried out (9.30 a.m.-5.30 p.m.); they also carried out a statistical analysis of the results. For the study of the nasal mucociliary transport (MCT) time, an original composition of vegetable charcoal powder and saccharin powder at 3% is used. Vegetable charcoal powder was chosen because, not only it is non-toxic and easy to trace, but also because it is insoluble in water and therefore able to provide data on MCT time much nearer to that of effective MCT. Pure saccharin powder was added to the vegetable charcoal powder both in order to offer further data on a soluble substance as opposed to an insoluble one, and also because, as such, it interacts readily with the fluid which covers the mucus and provides an MCT time presumably nearer to that of clearance. From the statistical analysis of the data, it is possible to affirm that charcoal powder is the most suitable inert substance for the quantification of the parameter of 'normality'.

Adult↗
PubMedDate not supplied

Specific local immunotherapy in nasal allergy (preliminary report).

The preliminary results are presented of a study carried out on 23 subjects with nasal allergy to graminacea, 10 of whom were used as a control group to verify the clinical advantages and the possible side effects of a specific local immunotherapy carried out in spray form using progressively increasing doses of allergen in aqueous solution. From a clinical point of view, on the grounds of the score in the clinical diary, we were able to show that during the preseasonal stage only 5 patients treated with the allergen were free of symptoms as were the controls, whereas during the critical phase they were all free of symptoms in contrast to the crisis presented in the control group. The increase in the threshold of nasal provocation and in the serum level of blocking antibodies, revealed in the majority of the subjects affected by pollinosis and treated locally with the allergen, are to be considered fundamental to the clinical advantage obtained. In agreement with what has already been revealed after specific nasal provocation, local treatment with allergens caused in a majority of cases a slight increase in the time of mucociliar clearance, a phenomenon which must be taken carefully into consideration in as much as it could eventually represent an adverse side effect which needs an adequate countermeasure.

Adolescent↗
PubMedDate not supplied

[Cytologic findings on chronic inflammatory disease of the vocal folds].

The usefulness of cytologic diagnosis in laryngeal pathology is still controversial, also in the cytopathologist's opinion. A sampling procedure such as routine cytodiagnosis can be considered useful for both diagnosis and treatment of non-surgically related laryngeal diseases. This study was designed in order to demonstrate how cytodiagnosis can be useful in etiologic and pathogenetic diagnosis of chronic non-specific inflammatory diseases of the vocal folds. Cytologic sampling was carried out on brushing material of simple and hyperplastic laryngeal inflammations and on normal vocarfolds which were used as control. Through cytologic examination it was possible to evidence specific morphological findings which allowed differentiation of not only healthy from diseased vocal cords, but also hyperplastic from simple inflammatory processes. Moreover, the high incidence of goblet cells and cylindric squamous metaplasia in hyperplastic corditis, as well as the frequent presence of fungal involvement in the simple forms, prompted the Authors to hypothesize pathogenetic mechanisms as well as progression inducing factors of the pathologies in question.

Carcinoid Tumor↗