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E Defrise-Gussenhoven

Publications and source records attributed to E Defrise-Gussenhoven.

15 recordsLinked to original sources
PubMed1985

NOR variability in twins.

The number of AgNOR (NOR+) and the amount of AgNOR (NORM+) were analysed by means of two multilevel analyses of variance in a total of 12 twin pairs: 3 female and 4 male MZ and 5 male DZ pairs. In the first analysis, only zygosity was controlled; in the second, chromosome types D and G were controlled as well as the interaction between chromosome type and zygosity. For NOR+ and NORM+, when chromosome types D and G are not distinguished, the within-pair variance is greater, though not significantly, in DZ than in MZ pairs; but it is highly significantly greater when chromosome type (D or G type) is under control. This confirms an important genetic determination of NOR+ and NORM+ when in the ANOVA model the D and G types are controlled. However, nongenetic factors also influence the Ag-NOR patterns, but not enough to conceal the genetically defined rDNA pattern. Indeed, about 50% of the cells transcribe their rDNA in a way not closely dependent on the rDNA background and significant intrapair differences of NOR+ pattern exist in MZ twins.

Analysis of Variance↗
PubMed1985

Possible linkage relationship between genetic markers and blood magnesium and zinc. A twin study.

In a sample of 63 like-sex dizygotic twins, red blood cell and plasma magnesium and red blood cell zinc concentrations were analyzed for linkage to each of 23 genetic systems by estimating correlation between proportion of genes identical by descent and biological resemblance for the trait. The results suggest possible linkage of red blood cell magnesium with the HLA locus and of red blood cell zinc with the GLO1 locus. However, studies applying more powerful tests are needed to confirm such conclusions.

Female↗
PubMed1983

Genetic and environmental factors in head and face measurements of Belgian twins.

Seventeen head and face measurements of 205 twin pairs, aged 18 to 25 years, are analyzed. In both sexes a significant genetic variance component is found for head length, head breadth, and frontal breadth, for seven breadth measurements of the face, for physio-face height, and nose height. A significant genetic variance component is found for nasion-gnathion, nasion-stomion, and lips height in males and for the two ear measurements in females. We suggest that the sex difference for heritability may be due to random factors and to continued growth from 18 to 25 years in males.

Adolescent↗
PubMed1983

C heterochromatin variation in couples with recurrent early abortions.

The possible influence of the high polymorphic C heterochromatic regions of human chromosomes 1, 9, 16, and Y on meiotic chromosome segregation was investigated. Faulty chromosome segregation may be the result of either an abnormal quantity of C heterochromatin on the homologues, or disequilibrium between the homologues. The aim of our study was to determine whether either a variation in the amounts of total C heterochromatin or differences in the amounts of C heterochromatin between homologues could lead to faulty chromosome segregation. The study was performed on C banded metaphases obtained from peripheral lymphocyte cultures of 15 couples with recurrent early abortions and 15 control couples, all Caucasians. Analysis of variance was first performed on separate metaphases to measure intra-individual, inter-individual, and between population variation in a hierarchical model. Since the significant intra-individual differences covered the other parameters we performed, secondly, a one way analysis of variance on the mean values of metaphases per person in order to measure the inter-individual and between population variation. The results did not show a relationship between C heterochromatin lengths and occurrence of recurrent abortions.

Abortion, Habitual↗
PubMed1982

Genetic and environmental influences on body measurements of Belgian twins.

A study of 100 MZ and 67 DZ twin pairs aged 18 to 25 years has shown a highly significant genetic contribution to the following measurements: standing and sitting height; height on tragus; arm length; biacromial, biiliac, and bitrochanteric diameter; weight; circumference of thigh and of upper arm relaxed and contracted; and head length and breadth. The twins were brought up together and of the same socioeconomical, geographical, ethnical, and cultural origin. Zygosity diagnosis was based on 22 to 26 blood groups. The means of the measurements were smaller in MZ than in DZ twins, some of them significantly so. The intraclass correlation coefficients of the MZ cotwins were all significant and greater than those of the DZ cotwins. In families of same geographical origin, sib-sib correlations were somewhat smaller than those of the DZ cotwins, but for the three diameters of the body the order was reversed.

Adolescent↗
PubMed1981

The inheritance of plasma and red blood cell magnesium and zinc levels studied from twin and family data.

The variability of magnesium and zinc concentrations in plasma and erythrocytes was investigated by twin and family studies. Twins were sampled in two distinct ways and in two different West-European regions. In one of the samples, a distinction was made between twins liver together and twins living apart. Two series of families were studied, one in a homogeneous environment, the other in a more diverse environment. Samples were compared by variance analysis. The results show 1) that genetic variability is significant for red blood cell (RBC) magnesium and zinc, minor for plasma magnesium and absent for plasma zinc; 2) that the family environment affects the extent of resemblance between twins and between siblings more for plasma levels than for RBC levels of magnesium and zinc. Furthermore, the intercorrelation analysis suggests that the genetic regulation systems of RBC magnesium and zinc are different, whereas some of the environmental regulation systems of plasma magnesium and zinc are the same. Biological interpretations are brought forward and discussed.

Adolescent↗
PubMedDate not supplied

Testing for the presence of genetic variance in factors of face measurements of Belgian twins.

Factor analysis with VARIMAX rotation was used to analyse 15 face measurements in Belgian same-sexed twins, aged 18-25 years: 39 dizygotic and 57 monozygotic male pairs and 42 dizygotic and 67 monozygotic female paris. According to Christian's model, we used the ratio of the within-mean squares of dizygotic and monozygotic pairs to test for the presence of a genetic component in the variance of the facial dimensions and of all the rotated factors were statistically significant (P less than 0.05), suggesting a genetic component in the variance. The probabilities of the F values were generally lower in males than in females. The factor analysis yielded five main factors of which three were well separated: face height, ear size and lips. The two others were breadth factors, but were less clearly defined, probably due to a bad selection of variables. A comparison of the F values of the factors with those of their contributing variables seemed to indicate that well-defined factors may better describe genetically determined structures than the original variables can.

Adolescent↗