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Biomedical subjects

E Delilbaşi

Publications and source records attributed to E Delilbaşi.

5 recordsLinked to original sources
PubMed1993

The effects of in vivo selenium supplementation on the amplitude of the spontaneous contractions and the responses to acetylcholine in isolated rabbit ileum.

This study was carried out to investigate the effect of selenium supplementation at a therapeutic level on the isolated ileum contractions and the acetylcholine responses in New Zealand rabbits. While no difference with respect to the controls was found in the spontaneous ileum contraction frequencies a significant increase in the contraction amplitude was noted after 15 days of supplementation. Increasing concentrations of acetylcholine in the perfusion solution resulted in a significant increase of the contraction amplitudes in the supplemented animals as compared to controls. The tissue selenium levels and the gluthathione peroxidase activities were also found significantly higher than the controls. No difference was observed between the contraction numbers in the two groups. These findings indicate that selenium supplementation does not influence the smooth muscle resting potential.

Acetylcholine↗
PubMed1991

Selenium and Behçet's disease.

Behçet's disease is an inflammatory disorder of unknown etiology, characterized by recurrent oral and genital aphthous ulcers, ocular inflammation, and skin lesions of erythema nodosum and acneiform eruptions. Selenium (Se) affects all components of the immune system, i.e., the development and expression of nonspecific, humoral, and cell-mediated responses. In general, a deficiency in Se appears to result in immunosuppression, whereas supplementation with low doses of Se appears to result in augmentation and/or restoration of immunologic functions. In this study, the distribution of Se and IgG, IgM in serum were compared in samples from healthy adult control and Behçet's disease patients. The serum Se levels were measured by AA-30-40 Varian Spectra, and immunoglobulins were measured by immunodiffusion technique. The mean (SD) serum Se level of 54.24 +/- 8.06 ng/mL among Behçet's disease subjects was significantly different (P less than 0.01) from that in the control subjects (90.01 +/- 9.94 ng/mL). We also measured IgG and IgM as 10.01 +/- 2.74 mg/mL and 1.26 +/- 0.29 mg/mL, respectively for patients, and 15.08 +/- 4.73 mg/mL and 1.58 +/- 0.43 mg/mL for controls. The mean values of IgG and IgM for patients were significantly (P less than 0.05) different from the values of controls. It seems, therefore, that a deficiency in selenium impedes the humoral immune response.

Adult↗
PubMed1988

The quantitative investigation of infrared laser effects on the levels of copper and zinc in various tissues.

In order to study the effects of infrared laser irradiation on biological systems, the levels of copper and zinc in various irradiated tissues have been investigated. The zinc level in the muscle of the irradiated group increased (P less than 0.001) compared with the control group while in submandibular glands its level decreased (P less than 0.001). The copper levels in these two types of tissues decreased significantly (P less than 0.001). In irradiated skin, both copper and zinc levels increased compared with the control group (P less than 0.005). Quantitative determination of the trace elements copper and zinc indicated the necessity for more detailed studies of the effect of infrared laser irradiation at the cellular level.

Animals↗
PubMedDate not supplied

Serum selenium and glutathione-peroxidase activities and their interaction with toxic metals in dialysis and renal transplantation patients.

Selenium, aluminum, cadmium, and magnesium concentrations and glutathione-peroxidase activities in sera of 35 healthy individuals, 30 renal transplants, and 30 hemodialysis patients were measured. Serum selenium, aluminum, and cadmium concentrations in both groups of patients were higher than the controls (p less than 0.001), whereas the serum glutathione-peroxidase levels were lower (p less than 0.001). According to our results, it can be concluded that the patients receiving hemodialysis are subjected to more toxic elements than the transplantation patients. These findings imply that dietary selenium supplement may be suggested in renal failure for the detoxification of elements, such as cadmium and mercury. The essential trace element selenium takes part not only in the direct protection of endothelial cells against the accumulation of aggressive oxygen species, but also in the prevention of the toxic effects of cadmium or in the modulation of the active calcium transport.

Adolescent↗