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Biomedical subjects

E Dennis

Publications and source records attributed to E Dennis.

23 records · Page 2Linked to original sources
PubMed1980

Clinical observations in 42 patients with Lassa fever.

Under continuous observation of several months, 42 patients from the eastern province of Sierra Leone, Liberia (Lofa County), and neighbouring Guinea were identified as Lassa fever cases by indirect immunofluorescent antibody technique, indicating that the disease is endemic in these areas. The clinical course varied from mild disease to severe illness with haemorrhagic disorders. The fatality rate was 14%. The occurrence of only two possible secondary cases suggests that person-to-person spread of the disease is unimportant epidemiologically. There was a wide range of patients' ages, tribes, and occupations, including a 2 months old baby and a white US citizen. Clinical, laboratory, and histopathological investigations demonstrated the panorganotropism of Lassa virus. Haematological tests in few selected haemorrhagic cases with Lassa fever did not support coagulation disorders or thrombocytopenia as causing the bleeding tendency. The histopathologic changes bear resemblance to those observed in Argentinian and Bolivian haemorrhagic fever, both being caused by viruses of the Arena group. However, Lassa virus hepatitis may be differentiated from liver lesions occurring in yellow fever, Marburg virus disease, and Ebola (Maridi) haemorrhagic fever.

Adolescent↗
PubMed1976

Donovanosis in Papua New Guinea.

Clinical and epidemiological observations on 87 cases of donovanosis seen at Port Moresby General Hospital are presented, with detailed reports of three cases in which the disease was more severe. The circumstances of infection described were consistent with venereal transmission. Chloramphenicol and gentamicin were effective in curing the disease, while streptomycin was found to be ineffective in a number of cases tested. Complement-fixation tests with Donovania antigen revealed the presence of antibodies in all but one of 23 cases tested, and in nine out of fourteen other patients who on clinical grounds were suspected of having donovanosis but were negative by smear test. The complement-fixation test with Klebsiella antigen was found to be highly specific for donovanosis, but less sensitive than the test using Donovania antigen. The intracellular location of Donovania in tissue and the presence of antibodies which are apparently not protective suggest that cell-mediated immunity may be important in defence against Donovania infection.

Adolescent↗
PubMedDate not supplied

The diversity of case management needs for the care of homeless persons.

Health care providers have been attempting to meet the special needs of homeless people on a national level since 1984. The need to implement strategies specific to serving the diversity of services required by homeless people has been apparent. To devise appropriate strategies, clinical information was drawn from the Health Resources and Services Administration-Health Care for the Homeless (HRSA-HCH) projects, which were created in 1987 primarily to fill such a need. In addition, data gathered by the HCH projects (1984-87) funded by the Robert Wood Johnson and Pew Memorial Trust were used. It is suggested that the past mode of providing health care for the homeless has been found to be inadequate when confronting the complex problems of the homeless person of today. In general, health care providers need to focus more on case management activities, which may include activities not necessarily associated with the provision of health care services (for example, finding and providing food, clothing, shelter, and assessing entitlement eligibility) to achieve the ultimate goal--stabilization--and when possible, reintegration of the homeless person back into society.

Adolescent↗