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Biomedical subjects

E Di Segni

Publications and source records attributed to E Di Segni.

At least 55 records · Page 3Linked to original sources
PubMed1980

Permanent overdrive pacing for the suppression of recurrent ventricular tachycardia in a newborn with long QT syndrome.

A newborn with long QT interval and repetitive ventricular tachycardia of the "torsade de pointes" type was seen at the age of one day. The arrhythmia was resistant to lidocaine, propranolol and atropine, but was controlled by isoproterenol infusion. A transvenous pacemaker, inserted at three days of age, suppressed the ventricular tachycardia at stimulation rates above 100/minute. At 19 days of age a permanent pacemaker at pulse rate of 119 beats/minute was implanted. At one year of age the infant was thriving and was completely free of ventricular arrhythmia.

Cardiac Pacing, Artificial↗
PubMed1980

The beneficial effect of the beta blocker timolol in stable agina pectoris.

Timolol is a new beta blocker with cardioselective properties. A single blind controlled study was performed to assess the efficacy of timolol maleate in doses of 10 to 30 mg per day in 20 patients affected by stable angina pectoris. The patients received a placebo for a baseline period of 2 weeks, followed by 12 weeks of timolol. The number of anginal attacks dropped from 14.9 attacks per week in the baseline period to a minimum of 4.6 attacks per week in the sixth week of treatment (P less than 0.01). The number of tablets of nitroglycerin taken per week was reduced from 6.5 during the baseline period to 2.3 in the sixth week of treatment. Resting heart rate decreased from a baseline mean value of 72 beats per minute to 51.7 and 53.7 per minute at weeks 6 and 12 respectively (P less than 0.01). Blood pressure both at rest and during exercise was significantly reduced. The mean work index measured during bicycle ergometry was 127 units before treatment; it increased by 29.4 units and 36.1 units during week 6 and week 12 respectively (P less than 0.05). There was a marked symptomatic improvement in 50% of the patients. Mild fatigue was a common side effect but it disappeared following reduction of dose. We concluded that timolol maleate significantly reduces the number of anginal attacks and increases the work capacity of patients affected by stable angina pectoris

Adrenergic beta-Antagonists↗
PubMed1979

False aneurysm of the right atrium.

A false aneurysm of the right atrium is described. The false aneurysm appeared after open-heart surgery and was probably related to loosening of a right atrial suture. Because of the low pressure in the right atrium, the danger of rupture seemed to be low, and conservative therapy was chosen.

Female↗
PubMed1979

The beneficial effects of verapamil in chronic atrial fibrillation.

Digitalis preparations frequently fail to control heart rate in many patients who have chronic atrial fibrillation, particularly during physical exertion. The effects of orally administered verapamil, 160 to 240 mg/day, on the heart rate at rest and during mild exercise were studied in 23 digitalized patients with chronic atrial fibrillation of various causes. Verapamil substantially reduced the excessive heart rate response to exercise in well-digitalized patients who had chronic atrial fibrillation.

Aged↗
PubMed1978

Procainamide-induced left anterior hemiblock of the 2:1 type (pseudoelectrical alternans).

A selective defect in cardiac conduction in the anterior division of the left bundle branch was induced in a patient by therapy with procainamide hydrochloride. The defect in conduction, when intermittent, resulted in 2:1 Wencklebach sequences and produced a pattern similar to classic electrical alternans. The prognosis in drug-induced alternans is good, and it is important to differentiate it from true electrical alternans.

Aged↗
PubMed1977

Bradycardia-related (phase 4) left anterior hemiblock.

A case is presented in which left anterior hemiblock (LAH) appeared transiently after the pause terminating atrial pacing, after atrial premature beats and during the slowing of sinus rhythm induced by carotid sinus massage. The transient LAH is attributed to phase-4 block, and is reported in order to add weight to the hypothesis that phase-4 block is a significant factor in the genesis of discrete conduction blocks in the human heart.

Aged↗
PubMed1976

The Wenckebach phenomenon between electric pacemaker and ventricle.

Two cases which exhibited a Wenckebach form of exit conduction between an electrical pacemaker and the ventricular myocardium are presented. This manifests with increasing latency (stimulus to QRS intervals) and ultimate stimulus failure (block). The cycle then repeats itself. The QRS duration also increases progressively within each cycle. The phenomenon connotes an adverse prognosis. Several postulates regarding the mechanism are discussed.

Female↗