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Biomedical subjects

E Diao

Publications and source records attributed to E Diao.

2 recordsLinked to original sources

Common tumors.

Common tumors of the hand and upper extremity are, by definition, benign conditions. There is a predictable pattern of occurrence and presentation for many of these lesions. The practitioner should always bear in mind, however, that any tumor that appears anywhere in the body can appear in the hand and upper extremity. Moreover, several of the benign conditions can, in certain clinical settings, have a predilection for transformation or association with more aggressive conditions. We would emphasize that the approach to any tumor be carefully considered and include an appropriate differential diagnosis. Any suspicious lesion should be examined thoroughly, including first-order screening tests, history, physical examination, radiographic imaging, and laboratory evaluations followed by more detailed diagnostic imaging prior to surgery. Surgery should be approached as a biopsy, with the possibility of frozen section analysis, and the possibility of a two-staged operation for tumor removal with appropriate margins if necessary.

Bone Neoplasms

Kinetic and biochemical heterogeneity in vertebrate chondroepiphyseal regions during development.

The purpose of this study was to see if kinetic and biochemical heterogeneity could be documented in vertebrate chondroepiphyseal regions as they develop from mesenchymal condensations to cartilage. The kinetics of developing proximal and distal femoral chondroepiphyseal regions were studied from early limb bud stage to newborn animals in chicks, mice, and rabbits with thymidine autoradiography. Proteoglycan synthesis in the proximal femoral chondroepiphyseal region of the rabbit was studied with radioactive sulfate incorporation at 28 days of gestation and at 1 and 4 days after birth. The results indicated that these kinetic and biochemical characteristics of the developing chondroepiphyseal regions became heterogeneous very early in development. This early programming of populations of cells for division and for different biochemical functions existed during the fetal period when heterogeneity has been described histologically but has not been well documented.

Animals