Interaction of the inhibitor of the 3',5' cyclic AMP phosphodiesterase of Dictyostelium discoideum with the Affi-Gel blue.
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Adenosine Monophosphate↗
Biomedical subjects
E Dicou
Publications and source records attributed to E Dicou.
A separate phosphodiesterase for the hydrolysis of cyclic guanosine 3',5'-monophosphate in growing Dictyostelium discoideum amoebae.
The presence of a cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase in mutant Dictyostelium discoideum amoebae, deficient in cyclic adenosine 3',5'-monophosphate (cAMP) phosphodiesterase is demonstrated. This enzyme shows a high affinity for cGMP and is not affected by cAMP at concentrations of up to 0.3 mM. It is activated by Mg2+ and Mn2+, and displays no apparent heterogeneity. Biochemical analysis of wild-type amoebae revealed the presence of a cGMP-specific phosphodiesterase sharing several common characteristics with the enzyme of the mutant amoebae. From the evidence presented in this report, it is concluded that the cGMP and cAMP phosphodiesterases of D. discoideum are under separate genetic control.
3',5'-Cyclic-AMP Phosphodiesterases↗
Purification of the inhibitor of the 3'-5' cyclic AMP phosphodiesterase of Dictyostelium discoideum by affinity chromatography.
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3',5'-Cyclic-AMP Phosphodiesterases↗
Synthesis of Dictyostelium discoideum secretory proteins in Xenopus laevis oocytes.
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Animals↗