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Biomedical subjects

E Dugan

Publications and source records attributed to E Dugan.

22 records · Page 2Linked to original sources
PubMed1976

Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.

Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpopulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.

Animals↗
PubMed1975

Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.

Specific anti-Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti-Ia antibodies, but not with specific anti-H-2K antibodies. The population of splenic B cells resistant to anti-Thy-1.2 serum and complement was blocked in a very similar manner by anti-Ia serum, but not by anti-H-2 serum.

Animals↗
PubMedDate not supplied

Disclosure of physician incentives: do practices satisfy purposes?

Under legal pressure, discussion has quickly shifted from whether health plans should disclose how they pay their physicians to how, when, and what should be disclosed and by whom. This paper describes health plans' disclosure practices and evaluates their adequacy and likely impact. It begins by explaining how different reasons for disclosure alter the form and content of disclosure, illustrating these approaches with actual examples. The paper concludes with a recommended approach that attempts to layer and stage disclosures so that people have as much information as they want, when they need it.

Attitude to Health↗