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Biomedical subjects

E Duhard

Publications and source records attributed to E Duhard.

4 recordsLinked to original sources

[Management of presumed onychomycosis in private practice].

BACKGROUND: The aim of this cross-sectional epidemiological survey was to describe the demographic and clinical characteristics of patients consulting for presumed onychomycosis and methods of treatment used by dermatologists in private practice. PATIENTS AND METHODS: The study was conducted among 209 dermatologists in private practice, and involved 2 041 patients with dermatomycosis, from among whom we isolated a total of 531 subjects with onychomycosis. RESULTS: The most commonly affected site was the foot (92.3%), particularly the big toe (93.9%). Matrix involvement was seen in 46.9% of cases. The clinically suspected diagnosis was confirmed by mycological examination in just under half of these patients. The predominance of trichophyton species was confirmed in 64.4% of cases, with Trichophyton rubrum being the main agent (53.2%) followed by Trichophyton mentagrophytes (10.1%). Results were negative in 25.6% of cases. In most instances, treatment was initiated before the results for samples analysis were received. Oral treatment, either with or without topical therapy, was initiated in 85.3% of cases with matrix involvement and in 34% of cases without matrix involvement. DISCUSSION: This survey reveals a wide disparity in diagnostic criteria for onychomycosis as well as treatment methods among dermatologists in private practice. Mycological samples, which alone can confirm the fungal origin of onychopathy, were taken in less than half of all the cases studied. The most commonly prescribed oral treatment was terbinafine. This was frequently instituted in the absence of any matrix involvement and without confirmation of the diagnosis.

Cross-Sectional Studies↗

[Normal and mycotic nail].

Knowledge of anatomy and physiology of the nail unit is necessary to understand onychomycosis, their clinical patterns, and response to the different treatments. It was useful for the discovery of new transungueal products. In this chapter, we describe anatomy and physiology of the normal nail and the main routes of fungus entry that lead to the onychomycosis.

Humans↗

[Prevalence of longitudinal melanonychia in the white population].

OBJECTIVES: The aim of this study was to determine the prevalence of longitudinal melanonychia (ML) in white subjects in order to obtain epidemiological data suggesting management strategies. PATIENTS AND METHODS: We included 99 hospitalized patients in this study, all were examined by a dermatologist. Another 4,400 healthy subjects were examined by a general practitioner. Criteria retained were age, sex, the presence or not of ML, the localization, number of bands, intensity of the coloration and size. RESULTS: The prevalence of ML was 12.6 +/- 3.4 p. 100 (CI 5.9-19.3) and 1.4 +/- 0.18 p. 100 (CI 1.3-1.75) respectively in the 99 and 4,400 subjects. The percentage of subjects increased progressively with age, particularly after 45 years and reached a peak between 56 and 65 years. The age distribution was identical. The most frequent localization was the thumb, followed by the great toe and the index. None of the ML observed had a clinical presentation suggestive of melanoma and no biopsies were taken. CONCLUSION: The frequency of melanonychia is thus higher in this series than that reported by previous studies where less than 1 p. 100 of the subjects had melanonychia. It was highest between the ages of 45 and 65 years. These results should be used when counselling patients and proposing systematic exeresis of ML above the age of 45 years.

Adolescent↗