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Biomedical subjects

E E DANIEL

Publications and source records attributed to E E DANIEL.

At least 19 recordsLinked to original sources
PubMed1965

INFLUENCE OF GLUCOSE ON THE TRANSMEMBRANE ACTION POTENTIAL OF ANOXIC PAPILLARY MUSCLE.

The response of the cat papillary muscle to anoxia has been found to alter depending on the glucose concentration in the medium. At a glucose concentration of 5 mM anoxia caused a marked reduction in force of contraction and action potential duration within 20 minutes. At a glucose concentration of 50 mM anoxia induced similar changes in the force of contraction but little or no change in action potential duration. Elevation of glucose concentration during an anoxic interval reversed the anoxia-induced changes in action potential but had little effect on force of contraction. This effect of glucose could be partially duplicated by xylose and 2-deoxyglucose and in addition, 2-deoxyglucose has been found to prevent the effect of subsequently added glucose. These sugars appear to be transported by a system responsible for glucose transport but are not metabolized to any extent. It would appear therefore that transport of glucose is in some way related to transport of potassium as increased potassium permeability is thought by many to be responsible for anoxia-induced changes in action potential duration.

Action Potentials↗
PubMed1964

A METHOD FOR THE ASSESSMENT OF REPORTS OF DRUG TRIALS.

A stepwise method for the assessment of reports of drug trials was used to determine the validity of drug reports published in The Canadian Medical Association Journal during the five-year period, January 1, 1956, to December 31, 1960. The method is simple and consists of applying four criteria: (1) the presence of adequate controls; (2) randomization of treatments; (3) objective assessment of drug effects; and (4) statistical analysis of results. If these criteria were absent, the assessment was stopped, and the report was felt to be invalid. A total of 203 articles were reviewed and 11 were found to fulfil these criteria. During the same period of time there were 93 additional case reports of drug effects, 39 of which described the effectiveness of a drug without there being adequate controls. The remainder of the case reports described drug toxicities.

Canada↗