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Biomedical subjects

E E De Bruyn

Publications and source records attributed to E E De Bruyn.

4 recordsLinked to original sources
PubMed1998

The relationship between mutual family relations and child psychopathology.

The associations of the mutual mother-child, father-child, and mother-father relationship and various patterns of family relations with child psychopathology were investigated in a sample of 137 families referred to outpatient mental health services. Assessment of the relative association of the different family dyads showed that both the mother-child and the mother-father relationship were related to child problem behaviour. However, whereas the mother-child relationship was consistently more related to externalising behaviour, the mother-father relationship was particularly related to internalising behaviour. Our findings gave clear support for the cumulative risk model: having more negatively qualified relationships was associated with more problem behaviour. Furthermore, our results suggested a protective influence of the parent-child relationship: having one or two positive parent-child relationships was associated with less problem behaviour. No support was found for the cross-generational coalition hypothesis. Implications for future research are discussed.

Adolescent↗
PubMed1996

The riminophenazines, clofazimine and B669, inhibit potassium transport in gram-positive bacteria by a lysophospholipid-dependent mechanism.

The effects of the riminophenazine antimicrobial agents clofazimine and B669 as well as those of lysophosphatidylcholine (LPC), on microbial K(+)-transporting systems were investigated in a range of Gram-positive and Gram-negative bacteria using 42K and 86Rubidium (86Rb) as tracers. Exposing the Gram-positive bacteria to 0.1-10 mg/L of the drugs resulted in a dose-related inhibition of uptake of both radiolabelled cations due primarily to the inhibition of their influx which was prevented by pretreating the microorganisms with 25 mg/L alpha-tocopherol (vitamin E) which forms a complex with lysophospholipids. In contrast, Gram-negative bacteria were resistant to riminophenazine-mediated inhibition of K(+)-transport, with only one of four well-characterised K(+)-transport system mutants of Escherichia coli, namely Kup, being affected by the antimicrobial agents. The selective antimicrobial activity of riminophenazines against Gram-positive bacteria is probably achieved by lysophospholipid-mediated inactivation of K(+)-transport, while Gram-negative microorganisms possess several K(+)-transport systems which are either inaccessible and/or insensitive to lysophospholipids. Thus, K(+)-transport systems may represent novel targets for antimicrobial agents.

Adenosine Triphosphate↗
PubMed1992

Diagnostic classification by experts and novices.

The present study examines differences between experts and novices in classifying symptoms and the effect of the nature of the task on classifying. The study involved three groups of subjects, two expert groups (n = 12, n = 10) and one novice group (n = 12). Thinking-aloud protocols were collected for two classification tasks: sorting of behavioural symptoms into predefined categories and intuitive clustering of behavioural symptoms. In a third task, experts and novices were asked to make typicality ratings of behavioural symptoms. The protocols were analyzed with respect to seven cognitive operations: (a) asking or giving information, (b) associating, (c) abstracting or labelling, (d) explaining, (e) neutral matching, (f) identifying, and (g) differentiating. Results showed an effect of experience and an effect of the task on the relative frequencies of these operations. No differences were found in typicality rating of experts versus novices. These contradictory findings are discussed in relation to Kolodner's model about the evolution of expertise.

Behavior↗