Biomedical subjects

E E Hill

Publications and source records attributed to E E Hill.

11 recordsLinked to original sources

PubMed2001

Craniofacial tissue engineering.

There is substantial need for the replacement of tissues in the craniofacial complex due to congenital defects, disease, and injury. The field of tissue engineering, through the application of engineering and biological principles, has the potential to create functional replacements for damaged or pathologic tissues. Three main approaches to tissue engineering have been pursued: conduction, induction by bioactive factors, and cell transplantation. These approaches will be reviewed as they have been applied to key tissues in the craniofacial region. While many obstacles must still be overcome prior to the successful clinical restoration of tissues such as skeletal muscle and the salivary glands, significant progress has been achieved in the development of several tissue equivalents, including skin, bone, and cartilage. The combined technologies of gene therapy and drug delivery with cell transplantation will continue to increase treatment options for craniofacial cosmetic and functional restoration.

Adipose Tissue↗

PubMed1993

Kong toys for laboratory primates: are they really an enrichment or just fomites?

Simple toys as enrichment devices have been associated with a rapid decline in their use by nonhuman primates. Other facets of toy presentation have not been described previously. For example, a comparison of the effect(s) of an enrichment device between two facilities should be validated if enrichment recommendations are to be made that affect diverse research facilities across the country. Additionally, a comparison of two methods of presentation (one highly accessible to the animal and the other less accessible) of the same enrichment device for potential differences in efficacy could provide direction in implementing an enrichment program based on simple toys. The handling of enrichment devices by nonhuman primates can lead to the spread of microbial contamination. The typical enrichment program rotates enrichment devices among animals to maximize the variety of stimuli available to each primate in the most economic manner. An adequate sanitation program is therefore pivotal to minimizing the potential for enrichment devices to be fomites. We conducted three experiments that addressed these issues. The results confirmed that, although the presence of a simple toy reduced behavioral pathology, there was variability in behavioral effect for an enrichment technique between facilities. Two methods of presentation (on floor and suspended) of a simple toy did not produce any significant differences in use. Finally, we demonstrated that microbial growth can persist on enrichment devices after they have been sanitized in a commercial cagewasher.

Animals↗

PubMed1985