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Biomedical subjects

E E Lack

Publications and source records attributed to E E Lack.

119 records · Page 7Linked to original sources
PubMed1978

Hyperplasia of vagal and carotid body paraganglia in patients with chronic hypoxemia.

Vagal and carotid body paraganglia were obtained from 43 randomly selected autopsies performed at the National Naval Medical Center. In each case, tissue from both sides was step sectioned and comparatively studied. The mean combined weight of carotid bodies in 37 control patients was 25.9 mg. There was good correlation between size and number of separate paraganglia comprising the vagal body (seven left, six right). Lobules were closely related to the ganglion nodosum and were actually within it in three instances. Tissue resembling parathyroid was encountered within 4 of the 86 resected vagus nerves. Lymphocytic infiltration occurred in carotid and vagal body paraganglia of 28% and 16% of patients, respectively. There was Schwann cell proliferatation in carotid body lobules of 2 patients; in another patient, talc emboli were present. The mean combined weight of carotid bodies in 6 patients with chronic hypoxemia was 47.6 mg, significantly greater than in the control group; in each case, lobules were enlarged. Chief cell hyperplasia occurred in vagal body paraganglia of 2 patients; in two other patients, lobules were large with equal proliferation of constituent cells. These morphologic findings indicate that in patients with chronic hypoxemia some vagal body paraganglia can be ascribed a chemoreceptor role similar to but probably less important than that of the carotid body.

Adolescent↗
PubMed1977

Paragangliomas of the head and neck region: a clinical study of 69 patients.

Over a 38-year-period 73 paragangliomas from the head and neck region were seen at Memorial Hospital. These occurred in 69 patients. There were 44 carotid body, 13 vagal body, eight jugulo-tympanic, and three nasal paragangliomas. In addition, one each arose in the orbit, larynx, and area of the aortic arch. Sixty-two patients were surgically treated while three received irradiation only and four were observed but not treated. Follow-up was obtained for 94% of the patients. There were six postoperative deaths, five of which occurred before 1945. Of those treated surgically, 37 had no evidence of recurrent tumor while the paragangliomas recurred locally in 11. All patients in the radiation and untreated groups had persistent tumor. Malignant behavior with death due to tumor was observed in five cases (four carotid body and one vagal body paraganglioma). Using modern techniques carotid body and vagal body paragangliomas can usually be managed by surgery alone. Other paragangliomas of the head and neck due to their anatomic location are sometimes best treated by a combination of surgery and radiation or only by radiation therapy.

Adult↗
PubMed1977

Carotid body hypertrophy in patients with cystic fibrosis and cyanotic congenital heart disease.

The carotid bodies from 71 patients ranging in age from 28 weeks' gestation to 30 years were obtained at autopsy. Patients were divided into two groups based on the presence or absence of chronic hypoxemia. There was a high correlation between the weight of individual carotid bodies in each case. Among the 12 patients with chronic hypoxemia, eight patients had carotid bodies heavier than predicted by statistical analysis. Of these eight patients, six had cystic fibrosis and two had cyanotic heart disease. Morphometric and cell population analyses of the carotid bodies from these eight patients and from those of the control population indicated that enlargement of the carotid bodies during normal or abnormal growth results from proportionate increases in lobule parenchyma and stroma. There was also an increase in the width and length of the lobules without an increase in the diameter of the cell cords or a change in the size or proportion of the chief cells. Growth and development of the carotid bodies were studied in a control group of 59 patients without chronic hypoxemia. There were no sex related differences in carotid body weights. The combined weight of the carotid bodies correlated most strongly with body weight, although there was some correlation with age and body length. A regression equation reflecting the data relating to body weight (BW) is: Combined weight of carotid bodies (in mg.) = 0.29 BW (in kg.) +3.0. Leukemic infiltrates were present in two patients with acute lymphocytic leukemia, and diffuse lymphocytic infiltration with nodule formation was present in one patient with mental retardation. Metaplastic cartilage was present in a carotid body of one patient.

Adolescent↗
PubMed1975

Lymphoid "hypophysitis" with end organ insufficiency.

A clinically hypothyroid patient had bi-lateral adrenal cortical atrophy and an extraordinary lesion of the pituitary gland. The parenchyma of the adenohypophysis was extensively replaced by a predominantly lymphocytic infiltrate with formation of nodules, many of which had pale germinal centers. There were areas of hyalinization with interstitial fibrosis and mildcapsular thickening. A similar lesion of the adenohypophysis has been reported previously, but without the evidence of adenohypophyseal insufficiency present in this case. It is speculated that this lesion may be related to cell-mediated autoimmunity and other organ-specific autoimmune disorders.

Adrenal Glands↗
PubMedDate not supplied

MR and CT findings in pulmonary artery sarcoma.

Pulmonary artery sarcomas are a rare and frequently forgotten cause of pulmonary artery occlusion. We present a case report that details magnetic resonance and new CT findings, which may help establish early diagnosis of this infrequently encountered tumor.

Aged↗
PubMedDate not supplied

Human leg heating using a mini-annular phased array.

The energy deposition pattern within an isolated human leg heated with a mini-annular phased array (MAPA) hyperthermia applicator has been determined. The non-tumor-bearing lower portion of a human leg amputated at the hip due to the presence of a large tumor in the thigh was "fixed" in a 50% ethanol in 0.9% saline solution. Subsequent to this fixation process, the leg was rehydrated in 0.9% saline and heated four times using a MAPA operating at 122 MHz. Specific absorption rates and electric field strengths were calculated from the rates of change of temperature with time measured at 143 different anatomical locations within the leg. When the leg was coaxial with the MAPA and the MAPA was axially positioned midway between the knee and the ankle, the points of maximum heating were skewed away from the center of the MAPA, towards the ankle of the leg and along the central axis of the MAPA. Significant temperature rise was measured inside the bone and the fat as well as inside the muscle of the leg. Bone heating was reduced when the leg was shifted away from the MAPA axis.

Amputation, Surgical↗
PubMedDate not supplied

Undifferentiated ("embryonal") sarcoma of the liver: ultrastructure of a case presenting as a primary intracardiac tumor.

We report the ultrastructure of an undifferentiated ("embryonal") sarcoma of the liver that presented as a right-sided intracardiac tumor in an 8-year-old boy. The patient eventually died because of repeated embolization of tumor to the lungs. At autopsy the hepatic primary was composed of primitive mesenchymal cells with occasional small cysts and ducts lined by benign-appearing epithelium. Electron microscopy of the mesenchymal cells indicated a limited capacity for pluripotential differentiation along fibroblastic, lipoblastic, and even myogenous lines. Epithelial elements closely resembled those lining normal bile ducts but contained increased fibrillar material with haphazard orientation. The histogenesis of this rare hepatic tumor is still unknown, but the occurrence of both epithelial and frankly sarcomatous elements within the primary tumor again raises the possibility of malignant transformation within a pre-existing mesenchymal hamartoma.

Child↗
PubMedDate not supplied

Intestinal malakoplakia in childhood: case report and review of literature.

We report the clinical and pathologic features of primary intestinal malakoplakia in a 14-year-old boy. The transmural involvement of small bowel, chronicity of the disease, and development of fistulas simulated chronic inflammatory bowel disease, specifically Crohn's disease. The diagnosis of malakoplakia was only possible by tissue biopsy. The clinical and pathologic differential diagnosis is briefly reviewed.

Adolescent↗