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E E Markova

Publications and source records attributed to E E Markova.

4 recordsLinked to original sources
PubMedDate not supplied

[Possible role of conformational changes in synaptic proteins in mechanisms of temporary connection formation].

Possible mechanism and the role of structural changes in the proteins of synaptic membranes in the process of formation of the temporary connection is discussed on the basis of existing assumptions and experimental data. Our experimental data suggest that during learning the structural changes occur in the synaptic membrane which are due to the conformation changes in the external and the integral proteins of membranes. Low-molecular proteins of synaptoplasma may play the role of the "carriers" and connectors and at a certain stage promote a conformation changes in synaptic proteins.

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PubMedDate not supplied

[Proteins of rat brain synaptic structures during conditioned reflex activity].

A comparative study was made of the structural-functional groups of proteins of synaptic structures in the cerebral cortex of albino rats during elaboration of a simple food-procuring reflex in one session. The results of estimation of quantitative and qualitative protein changes by the methods of isotope analysis and discelectrophoresis on polyacrylamide gel point to dissimilar changes in membrane and synapto-plasmatic proteins during learning. The process of temporary connections formation is accompanied by structural-chemical reorganizations of the synaptic membranes which evidently involve conformative transitions of external and integral proteins. There is a drastic rise in the rate of metabolism in the group of watersoluble proteins during learning, along with a possibility of "local" changes of synthesis in the fraction of low-molecular proteins.

Animals↗