Biomedical subjects

E E Nel

Publications and source records attributed to E E Nel.

4 recordsLinked to original sources

PubMed1979

Phenotyping of South African black tuberculosis patients for inactivation of isoniazid.

Studies of isoniazid inactivation rates in black tuberculosis patients from South Africa and Birmingham, Alabama, showed a higher frequency of fast inactivation than those of North American Caucasian patients. After an oral test dose of 10 mg/kg isoniazid the percentage of fast inactivators in black patients of South Africa and Alabama was close to 60% while in North American white participants (Canadian and Birmingham Caucasians), the frequency of fast inactivation was approximately 40%.

Administration, Oral↗

PubMed1979

Comparison of isoniazid phenotyping of black and white patients with emphasis on South African blacks.

Black tuberculosis patients from South Africa (S. A.) as well as from Birmingham, Alabama, U.S.A., showed a higher percentage of fast inactivators of isoniazid (INH) than that found in the North American white population, simultaneously sampled. In S. A. blacks, the frequency of fast inactivation was 57.9--59.6%, while in American blacks of Birmingham it amounted to 60.3%; in comparison to the above groups the rate of fast acetylators in Canadian Caucasians was 41.9% and in the USA white population 41.0%. For phenotyping of isoniazid inactivators a urine test was used. In this method the concentrations of INH (including isoniazidhydrazones) as well as acetylisoniazid were determined in the specimens collected 6--8 hrs following a test dose of 10 mg/kg INH.

Administration, Oral↗

PubMed1977

Mycobacterioses.

Explore the source record for details and available documents.

Antitubercular Agents↗

PubMed1977

Pulmonary disease associated with mycobacteria other than tubercle bacilli in miners.

Five patients with lung disease caused by mycobacteria other than tubercle (MOTT) bacilli are described. Mycobacterium kansasii was the causative organism in 4 patients and M. scrofulaceum in 1 patient. The species were repeatedly isolated from sputum specimens cultured on Löwenstein-Jensen medium. The clinical features, mycobacterial isolations, bacteriological properties of the pathogens and the therapeutic problems encountered are discussed.

Adult↗