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Biomedical subjects

E E Petersen

Publications and source records attributed to E E Petersen.

At least 19 recordsLinked to original sources
PubMed1992

[Bacterial infections in pregnancy].

The spectrum of bacterial infections during pregnancy is broad. Among blood-transmitted infections especially listeriosis endangers the child. More frequent are ascending and peripartal infections, which imperil both mother and child. The disturbed vaginal flora, which occurs in 10-30% of all pregnant women, has to be regarded as its reservoir. Cervicitis caused by gonococci or chlamydiae, but also high concentrations of facultative pathogenic bacteria are regarded as the main cause of the preterm rupture of membranes leading to preterm delivery. Especially feared is the group-A-streptococci infection, which appears more frequently. In 5% of all pregnant women a chlamydial cervicitis is found.

Amnion↗
PubMed1991

[Chlamydia infection. A common, usually mild, infection with often severe consequences].

Today, chlamydiae are among the most frequently sexually transmitted organisms. At least 5 to 10% of young, sexually active adults, will have a florid chlamydial infection. On account of its chronic nature, the paucity of symptoms, and the difficulty in diagnosing it, this infection is still underdiagnosed. The spectrum of the manifested pathologies range from genital to abdominal lesions, to conjunctivitis, pneumonia and arthritis. On account of the specific intracellular reproduction cycle, antibiotic therapy is not always able to completely clear up the infection. Today, chlamydial infection is the most common cause of infection-related sterility. During parturition, the neonate is often infected, with subsequent chronicity and sequelae.

Chlamydia Infections↗
PubMed1990

[AIDS and females. Change in problems for the gynecologist].

We report on our experience with 47 HIV-positive women, died in the meantime. 32% stated, that they had never taken i.v. drugs. Their clinical pattern varies greatly. Psychosocial problems and infections, such as genital herpes and candidosis and others predominate. Long-term controls of 12 couples with HIV-negative male partner only showed one case of HIV-transmission. Since 1980 21 children were born by these patients, 7 of them are seropositive 2 years after birth, and one of them has meanwhile died of AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Single dose pefloxacin compared with multiple dose co-trimoxazole in cystitis.

In a double-blind multicentre study the efficacy and safety of a single-dose treatment with pefloxacin (800 mg) was compared with a five-day treatment regimen of 960 mg co-trimoxazole twice daily in the therapy of acute uncomplicated cystitis in women. In order to maintain blindness, patients in the pefloxacin group received placebo to complement the full number of tablets. Nine centres were involved; 155 patients received pefloxacin and 161 patients received co-trimoxazole. Of these, 140 patients treated with pefloxacin and 145 with co-trimoxazole were considered valid for efficacy and safety analysis. At the first follow-up, after seven to ten days, 97.1% of the pefloxacin group and 95.2% of the co-trimoxazole group were bacteriologically cured. At the second follow-up visit, after 28 to 42 days, the urine culture was negative in 95.0% of the pefloxacin group and 90.3% of the co-trimoxazole group. A single dose of 800 mg pefloxacin was demonstrated to be as safe and at least as effective as a five-day regimen of co-trimoxazole in the treatment of uncomplicated cystitis.

Adult↗
PubMed1989

[Infections with herpes viruses in gynecology and obstetrics].

Genital herpes is a sexually transmitted infection that is feared in particular during birth, when the virus can infect the baby during its passage through the birth canal, and lead to the death of the neonate or lasting severe morbidity. Much more frequent, however, is recurrent herpes genitalis that can occur up into old age, and which is usually nothing worse than a nuisance. Owing to the wide spectrum of possible symptoms and their intensity, it is not infrequently recognized either very late in its evolution, or not at all. Varicella in pregnancy is also particularly feared, since it can (rarely) lead to congenital damage or, in the case of maternal peripartal varicella, to severe infection in the neonate.

Chickenpox↗
PubMed1989

[Diagnosis of toxoplasmosis in pregnancy].

Even today, toxoplasmosis infection during pregnancy is an unsolved problem. In studies of 2206 pregnant women, toxoplasmosis specific IgM-antibodies have been detected in 69 cases (3.1%). Using more sophisticated serological techniques only 12 active toxoplasmosis cases needing therapy remained. Decisive discrimination criteria of the various tests were exact time of the examination as well as the level of the antibody titer. Although only 12 toxoplasmosis infections were treated, no connatal infections have been observed. On the other hand, in some outpatients, referred to our clinic, cases of severe connatal toxoplasmosis infections were found although they had undergone therapy. To solve the problem of toxoplasmosis, we recommend a general screening before pregnancy if possible. For optimal results of this screening, serologic reference laboratories and efficient sonography units must be established to obtain, when required, umbilical venous blood.

Animals↗
PubMed1986

[AIDS: problems and consequences in gynecology and obstetrics].

The increasing infection of young pregnant women with the LAV/HTLV-III virus means that AIDS is now also becoming a problem for the gynecologist. This article reports on findings in 6 women, four of whom have borne a child. The three children examined to date are infected, with one of the children manifesting a lymphadenopathy syndrome. This supports the supposition that, in the majority of cases, a diaplacental transmission of the virus to the child takes place during pregnancy. Since pregnancy, moreover, leads to a deterioration in the patient's condition, termination should be advised to women who are seropositive. Now that women belonging to non-risk groups have been found to be infected, generous interpretation of the known indications for antibody scanning in young women is recommended.

AIDS-Related Complex↗
PubMed1985

[Amine colpitis, not only an esthetic problem: increased infection risk in labor].

In 76 women with non-specific vaginitis we could always isolate Gardnerella vaginalis and several anaerobics, especially Bacteroides species, in hgh counts. In 19 puerperae, bacteriologial examinations of the infected episiotomy wound yielded a spectrum of pathogens similar to that of non-specific vaginitis. In 74 per cent of the women with wound infection following episiotomy, non-specific vaginitis had either already been present before childbirth (and identified as Gardnerella vaginalis vaginitis), or was confirmed at the time of infection. Staphylococcus aureus was seen in 16 per cent of the wound infections, whereas other pathogens were identified in 10 per cent. In a prospective study on vaginal flora ante partum and rate of infection post partum, based on 405 vaginal deliveries, 80% of the examined pregnant women had a normal vaginal flora with lactobacilli. In 12%, we found Gardnerella vaginalis, and in 8% a mixed flora. Since the rate of infection in women with Gardnerella vaginalis vaginitis and episiotomy was found to be ten times higher than that in women with Döderlein's flora and episiotomy, it is obvious that Gardnerella vaginalis vaginitis is not just an aesthetic problem.

Adult↗