Biomedical subjects
E Ebling
Publications and source records attributed to E Ebling.
The sebotrophic action of growth hormone (BGH) in the rat.
Sebum production of rats was assessed by measuring the levels of fat extractable by diethyl ether from samples of hair clipped immediately after shampooing with sodium lauryl sulphate and 2 days later. By the use of matched litter mates in was unequivocally demonstrated that the response of the sebaceous glands to testosterone is virtually abolished by hypophysectomy and that it can be completely restored by pure bovine growth hormone.
The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lachrymal glands and of brown adipose tissue in the rat.
The relative responses to testosterone of the prostate, preputial, Harderian, and lachrymal glands, the seminal vesicles and the brown adipose tissue, have been compared in litter-mate, castrated and hypophysectomized-castrated rats, with or without treatment with bovine GH. The responses of both prostate and preputial glands, though not the seminal vesicles, were reduced by hypophysectomy, and restored by GH. Growth hormone had some independent action on the preputial glands, but most of its effect was synergistic with testosterone. The respinse of brown adipose tissue to testosterone was similarly reduced by hypophysectomy, but was not restored by the GH. The weights of the Harderian and lachrymal glands were not affected by castration, but they were considerably reduced by hypophysectomy. Growth hormone had a slight restorative effect on the Harderian glands, but none on the lachrymal glands.
The synergistic action of alpha-melanocyte-stimulating hormone and testosterone of the sebaceous, prostate, preputial, Harderian and lachrymal glands, seminal vesicles and brown adipose tissue in the hypophysectomized-castrated rat.
Alpha-Melanocyte-stimulating hormone was shown to act synergistically with testosterone to stimulate the sebaceous, prostate and the seminal vesicles in hypophys-ectomized-castrated rats. The sebaceous glands differed from the other three organs in that alpha-MSH not only acted synergistically, but also had a significant effect which was independent of the presence of exogenous testosterone. The response of the brown adipose tissue to testerone, considerably reduced by hypophysectomy, was not restored by alpha-MSH. The Harderian and lachrymal glands were also pituitary-dependent and their weights in hypophysectomized-castrated rats were not restored by alpha-MSH.
The responses of the sebaceous glands of the hypophysectomized-castrated male rat to 5 -androstanedione and 5 -androstane-3 ,17 -diol.
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The response of the sebaceous glands of the hypophysectomized-castrated male rat to 5 -dihydrotestosterone, androstenedione, dehydroepiandrosterone and androsterone.
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The response of the sebaceous glands of hypophysectomized-castrated male rats to adrenocorticotrophic hormone and to testosterone.
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The effects of thyrotrophic hormone and of thyroxine on the response of the sebaceous glands of the rat to testosterone.
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The influence of pituitary hormones on the response of the sebaceous glands of the male rat to testosterone.
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The influence of the pituitary on the response of the sebaceous and preputial glands of the rat to progesterone.
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