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Biomedical subjects

E El-Ghazzawi

Publications and source records attributed to E El-Ghazzawi.

10 recordsLinked to original sources
PubMed1979

Transmission and scanning electron microscopic studies of rhinoscleroma.

Using both types of electron microscope, combined transmission and scanning electron microscopic studies were done on 6 patients with rhinoscleroma. The present work suggests the possibility of two types of organisms causing the disease: one type--being in the majority--was a rod-shaped bacillus measuring about 3 micrometers; the other type was a short, stout bacillus with terminal spiral cilia. The ultrastructure of these bacilli has been described. The advantages and limitations of each type of electron microscopy in the investigation of rhinoscleroma have been discussed.

Humans↗
PubMed1979

Electron microscopic study of previously irradiated scleroma.

Nasal biopsies from 2 scleroma patients who had received previous X-ray therapy were investigated under the electron microscope. In the lamina propria, the majority of Mikulicz cells contained numerous small vacuoles. This was attributed to the effect of X-ray therapy causing temporary suppression of the inflammatory process followed by new granuloma formation. The vacuoles of the Mikulicz cells contained some fine granular and fibrillar material of unknown origin. Rounded electron-dense bodies with microprojections on their surface were present near some Mikulicz cells. These structures were considered to be Russell bodies. Occasional small lymph vessels with obstructed lumina were seen. This might indicate the rare spread of Klebsiella rhinoscleromatis bacilli to regional lymph nodes.

Adult↗
PubMed1979

The leprous testis.

A clinical investigative study of 148 male leprous patients demonstrated the presence of testicular lesions in 35 cases. Semen analysis revealed marked oligo-athenozoospermia in 10 cases and azoospermia in 25 cases. Testicular biopsies from leprous testes showed different histologic patterns ranging from spermatogenic arrest to complete hyalinization of both seminiferous tubules and interstitial tissue. Histochemical staining for neurovascular supply revealed degenerative nerve change in addition to altered permeability of the testicular capillaries. There was good correlation between the results of semen analysis and histological and histochemical examination of testicular biopsies.

Adolescent↗
PubMed1977

Effect of tympanic neurectomy on human parotid salivary gland. Histopathologic, Histochemical, and Clinical Study.

Five patients with bilateral chronic recurrent parotiditis and ten patients with unilateral persistent paratoid gland fistulas underwent tympanic neurectomies. Two biopsy specimens from the diseased gland were examined. The first biopsy specimen was taken at the time of operation, while the second one was taken six months later. All specimens were subjected to both histopathologic and histochemical investigations. Definite degenerative and atrophic changes occured in all parotid gland specimens taken six months after selective tympanic neurectomy. All patients were completely cured at about that time. This supported the practical indication of the selective tympanic neurectomy for treating certain benign disorders or diseases of the parotid gland that require persistent arrest of the function of its secretory units.

Atrophy↗
PubMed1975

An ultrastructural study of hypothalamic neurons in monkeys of different ages with special reference to age related lipofuscin.

Ultrastructural comparison hypothalamic neurons from the anterior, middle and posterior hypothalamus have been carried out both in young and aged Cynomologus monkeys. The overall ultrastructure of the hypothalamic neurons studied shows no fundamental difference. Neurons from the supraoptic, paraventricular and infundibular regions often exhibit a spiral arrangement of the smooth surfaced endoplasmic reticulum and the presence of neurosecretory granules (NSG). Lipofuscin is present both in the young and aged monkey. The progressive accumulation of lipofuscin and degenerative changes in the mitochondria are the main age related neurocytological changes. The rate of pigment accumulation however seems to differ in the various regions of the hypothalamus in the young and aged monkey. The young hypothalamus shows more pigment accumulation in the posterior part than in the anterior. In contrast, the aged hypothalamus revealed increased accumulation of pigment in the anterior part as compared to the posterior. The close topographical and morphological association of the pigment to the mitochondria and the pronounced degenerative age changes of the mitochondria, detrimental to oxidative and metabolic processes, suggest that lipofuscin is a stage in the life history of mitochondria and being a fundamental factor in aging. Noteworthy too is the increasing appearance of microglia cells or phagocytes filled with osmiophilic granules close to capillaries in the older age group of monkeys studied.

Age Factors↗
PubMedDate not supplied

[Effects of neurectomy of the tympanic plexus on secretion of the parotid gland in man. Histopathological, histochemical and clinical study (author's transl)].

This study involved five patients suffering from bilateral chronic parotiditis and then with a persistent unilateral fistula of the parotid gland. Two types of parotid biopsy were examined: the first taken during surgery and the second six months later. All of the specimens underwent histopathological and histochemical investigations. Definitive degeneration and atrophic type changes were seen in all the parotid fragments removed six months after selective neurectomy of the tympanic plexus. Six months after surgery, all of the patients were cured.

Atrophy↗