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Biomedical subjects

E Engel

Publications and source records attributed to E Engel.

At least 37 records · Page 2Linked to original sources
PubMed1987

Cytogenetic studies of human testicular germ cell tumours.

In a search for consistent cytogenetic alterations in testicular germ cell cancers we have thus far studied some twenty surgical specimens of seminomas and nonseminomatous tumours. From the literature and our results it is now clear that such testicular tumours generally have a hyperdiploid to hypotriploid chromosomal content, and frequently possess a possibly site-specific chromosomal marker, an isochromosome 12p. A significant correlation between the presence of the i(12p) and advanced clinical stages has been revealed in our study. Several other chromosomal regions are consistently involved in cytogenetic changes: 1p and 1q, 6q, 7p, 9q, 12p, 17q, and 22q. Although there is little doubt that characteristic chromosomal lesions exist in testicular germ cell tumours, the impact which specific lesions may have on tumour progression is still unclear.

Chromosome Aberrations↗
PubMed1987

[Fosfomycin levels in the cerebrospinal fluid of patients with and without meningitis].

18 neurosurgical patients were given 15 g fosfomycin at 8-hour intervals. Simultaneously serum and cerebrospinal fluid (CSF) concentrations were determined periodically over 8 hrs. In patients with noninflamed meninges the CSF-concentrations ranged between 6.48 and 8.98 micrograms/ml. In patients with meningitis the CSF-levels amounted to 20.28 and 39.80 micrograms/ml. For perioperative short-time prophylaxis and postoperative infections in neurosurgical patients therapeutically relevant fosfomycin levels against Staph. aureus und Staph. epidermidis can be achieved.

Adolescent↗
PubMed1987

[Angiography findings following myocardial infarct in young females: the role of oral contraceptives].

In 173 women less than 50 years of age with myocardial infarction, angiographic evidence of coronary sclerosis was observed in only 108 (62%). Completely normal coronary arteries were found in 15 patients (9%) and in 50 patients (29%) an isolated poorly delineated stenosis was found in the presence of otherwise completely normal coronary arteries. Of the 65 patients with myocardial infarction but without typical coronary sclerosis, 47 (72%) were taking oral contraceptives at the time of infarction. In 60% of the oral contraceptive users with infarction, angiographically, there was no evidence of typical coronary sclerosis. With the exception of cigarette smoking, the number of atherogenic risk factors in these patients was low such that myocardial infarction during treatment with oral contraceptives may possibly represent a separate disease entity distinguishable from coronary sclerosis. In support of this, in some cases, repeat angiography demonstrated spontaneous regression of the isolated stenosis. Etiologically, possible thromboembolic vascular occlusion has been assumed. In women in the premenopausal years, coronary sclerosis is uncommon and usually associated with a substantial number of atherogenic risk factors. In this case, 29% of the women had used oral contraceptives, the causal role of which remains uncertain. Even though oral contraceptive use is associated with a higher risk of myocardial infarction, apparently, it cannot be regarded as a typical atherogenic risk factor.

Adult↗
PubMed1986

Ring chromosomes and hematologic disorders.

Based on 5 years of cytogenetic evaluation in hematology, we report our observations on various hematologic proliferative disorders with ring chromosomes. Comparing our data to those previously published in the literature we analyzed the occurrence of the ring in relation to the age of onset, previous history of therapeutic or professional exposure to mutagenic agents, and mean survival. It is concluded that the presence of ring chromosomes may be linked to a poor prognosis.

Adult↗
PubMed1986

Effect of ecological viewing conditions on the Ames' distorted room illusion.

Ecological theory asserts that the Ames' distorted room illusion (DRI) occurs as a result of the artificial restriction of information pickup. According to Gibson (1966, 1979), the illusion is eliminated when binocular vision and/or head movement are allowed. In Experiment 1, to measure the DRI, we used a size-matching technique employing discs placed within an Ames' distorted room. One hundred forty-four subjects viewed the distorted room or a control apparatus under four different viewing conditions (i.e., restricted or unrestricted head movement), using monocular and binocular vision. In Experiment 2, subjects viewed binocularly and were instructed to move freely while making judgments. Overall, the main findings of this study were that the DRI decreased with increases in viewing access and that the DRI persisted under all viewing conditions. The persistence of the illusion was felt to contradict Gibson's position.

Adult↗
PubMed1986

Ectopic nucleolus organizer regions (NORs) in human testicular tumors.

Investigation of nucleolus organizer regions (NORs) in hematopoietic malignancies has indicated that the distribution and rearrangement of these regions may be more important in malignant tissues than is their number. In one of the few studies thus far reported on NORs in human solid tumors, we describe here Ag-NORs in a group of human testicular germ-cell tumors and the corresponding patients. Four of seven malignancies demonstrated consistent ectopic NORs; explanations could include chromosomal rearrangement (insertion?) or derepression of preexisting inactive NORs.

Animals↗
PubMed1986

[Prenatal diagnosis of 3 cases of ring G chromosomes: one 21 and two 22, one of which was de novo].

Three cases of ring G chromosome diagnosed by amniocentesis are reported. In two instances there was paternal transmission of a ring (one r21 and one r22) without clinical manifestation in the fathers, and the two babies resulting from these pregnancies were normal at birth. In the third case, in which a de novo ring 22 was observed in association with IUGR and oligoamnios, the fetus was aborted. The variable phenotypic effects of ring G chromosomes, as well as several aspects of genetic counseling are discussed.

Chromosome Aberrations↗
PubMed1985

Translocation 2;11 and other significant chromosome changes in acute monoblastic leukemia (M5) with clonal evolution: sequential clinical and cytogenetic studies.

An elderly woman presented with pancytopenia resulting from acute monoblastic leukemia (AMoL) type M5a. At the time of diagnosis, the marrow metaphase studies revealed a pseudodiploid idiogram: 46,XX,t(2;11)(q37;q23),(t(7;9;10)(q22;q22;p13). At relapse, 7 months later, a clonal derivative of the initial pseudodiploid pattern was identified. Though alterations of chromosome regions 7q22 and 9q22 are frequently seen in acute nonlymphocytic leukemia (ANLL), 11q structural anomalies are even more specific for this group of leukemias, and the involvement of band 11q23 is particularly striking in AMoL. Various chromosomes may take part in translocations with chromosome #11, but the participation of chromosome #2 as in this case is apparently rare.

Aged↗
PubMed1985

[Experiences with selection criteria in myelomeningocele surgery].

Between 1972 und 1983 85 children with myelomeningocele were treated according to the criteria for selective treatment as given by Lorber. The results of children with early or delayed operation and of those who had only supportive care are presented. Survival time and causes of death in the group of children not operated on are in particular given, the sequelae of selective treatment are discussed.

Cerebrospinal Fluid Shunts↗