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E Enríquez

Publications and source records attributed to E Enríquez.

5 recordsLinked to original sources
PubMed1999

Effects of weak acids on cation accumulation, delta pH and delta psi in yeast.

With glucose as carbon source, as reported by other authors (Conway et al., 1950), yeast cells accumulated large amounts of CO2, carbonic acid, bicarbonate and K+ than when grown with ethanol. The addition of propionic acid to the cells produced an increase in the potassium ion accumulation when cells were incubated with ethanol as substrate, but not when incubated with glucose. In disagreement with Ryan et al. (1971) and Ryan and Ryan (1972), the internal pH of the cells with ethanol was lower than with glucose, eliminating this factor as the limiting factor for potassium accumulation. When the membrane potential difference was estimated, it was found that it was higher with glucose as substrate than with ethanol. In addition, with ethanol the addition of propionic acid produced an increase of the membrane potential, in agreement with the idea of an accumulation of the anions of monoprotic acids, which, being not diffusible, increase the negative membrane potential inside, which can drive the accumulation of larger amounts of monovalent cations. It was also found that the addition of propionic acid to cells incubated with glucose as substrate produced an efflux of CO2 from the cells, so that an exchange of the acid appears to take place.

Bicarbonates↗
PubMed1996

Obstructive and restrictive pulmonary dysfunction increases disability in Parkinson disease.

OBJECTIVE: The purpose of this study was to determine in Parkinson disease the impact of pulmonary dysfunction on daily living activities (DLA). PATIENTS: Extrapyramidal motor impairment, pulmonary dysfunction, and DLA disabilities were studied in 58 Parkinson patients consecutively enrolled in a rehabilitation service at a university hospital. MAIN OUTCOME MEASURES: Extrapyramidal motor impairments were assessed by the Unified Parkinson's Disease Rating Scale (UPDRS) and the DLA disabilities by the UPDRS, Hoehn-Yahr, and Schwab-England scales. The pulmonary dysfunctions were assessed by spirometry with flow-volume loops, body plethysmography with lung volumes computation, and maximal inspiratory and expiratory static mouth pressures. RESULTS: Parkinson patients showed important modifications of pulmonary function with a decrease in forced vital capacity, forced expiratory volume in the first minute, and arterial PO2, and an increase in residual volume and total airway resistance (RAW). In addition, they showed a high incidence of airway ventilatory obstructions and restrictive dysfunction. The impact of lung disease on daily living activities in Parkinson disease patients was higher in subjects with restrictive pulmonary dysfunctions (Schwab-England test and turning in bed and adjusting bedclothes, walking, falling, and freezing when walking items of UPDRS) and airway obstructions (handling utensils, dressing and hygiene items of UPDRS). CONCLUSIONS: Airway obstructions or restrictive pulmonary dysfunctions present a high prevalence in Parkinson disease, contributing as a main factor for DLA dysfunctions. The evaluation and rehabilitation of respiratory disturbances should be systematically included in the management of these patients.

Activities of Daily Living↗
PubMedDate not supplied

Slender versus threatening angiodysplasias: observe, operate or obturate? A delusive decision.

Beside the immediate success of surgery and of embolization of angiodysplasias, certain number of patients return to medical consultation, because recanalization of the arteriovenous fistulae after their resection or obturation. From the presentation of two clinical cases of thoracic angiodysplasia: one of them slender, and threatening the other, the authors point out the complications and recurrence after surgical resection or arterial embolization. The recurrence takes place even when only one artery remains permeable after resection or embolization of the fistula. There are cases where the affected limb has to be amputated. However, angiodysplasia shows itself in the stump of the amputee limb. Uncontrolled angio-genesis is the natural history or postoperatory evolution of angiodysplasias, probably originated by an erroneous genetic program, which persist in spite of resection of the vascular malformation, causing a therapeutic failure.

Adult↗
PubMedDate not supplied

[Ergotism caused by automedication].

The authors report 7 cases of gangrenous ergotism (six women and one man) secondary to an overdose of ergotamine ingested in order to relieve migraine crisis. In all cases, patients presented symptoms and signs of severe arterial constriction confirmed by echography and angiography. Hallucinations were absent. Ergotamine ingestion was discontinued and treatment was based on vasodilators and sympathectomy. After treatment, all seven patients showed clinical improvement with disappearance of the vasospastic symptoms and signs, and an increase in the plethysmographic index of blood perfusion, measured by Doppler echography. These changes were observed even in a patient who lost two toes of the right foot. Although, none of the patients presented hallucinations, the authors made reference to the historical first use of the ergot in magic and religious rites that took place in Eleusis, at the time of classic Greece, as well as the more recent mystic use of ergot in Salem, New England, in 1692. Migraine is indeed a serious disease, frequently causing despair to the patient, who attempts to alleviate the migraneous crisis with an overdose of ergotamine. Accordingly, physicians must be aware of prophylactic vasodilating drugs, reducing the risk of ergotism.

Adult↗