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Biomedical subjects

E Eriksson

Publications and source records attributed to E Eriksson.

At least 19 recordsLinked to original sources
PubMed1979

Determination of prekallikrein in plasma by means of a chromogenic tripeptide substrate for plasma kallikrein.

A method for plasma prekallikrein determination utilizing a chromogenic tripeptic substrate is presented. The method has a good reproducibility and can easily be automized. Several parameters have been optimized. By using mixtures of deficient plasmas and pooled normal plasma or purified factors it was proved that prekallikrein was the factor determined and that more than 10% (of normal plasma concentration) of FXII and HMW kininogen were essential for the activation of prekallikrein in our method. Further experiments showed that the method was fairly selective and was not influenced by inhibitors present in normal plasma. The later finding was attributed to the high dilution of plasma made possible by using a potent activator and a sensitive substrate.

Dextrans↗
PubMed1979

White blood cell consumption in the microcirculation after a major burn.

The mesenteric microvasculature was observed before and after a distant full-thickness cutaneous burn in rats. Diameters, flow velocities, and white blood cell sticking and emigration were measured. Between 30 and 360 minutes postburn 13 to 16 WBC's were found to stick to the venular walls which had an area of 1.57 x 10(4) microns(2). Therefore, the number of WBC's emigrating from the vascular compartment during the 6-hour observation period could be as many as 0.51 X 10(9)/kg. Based on known values for total stores of WBC's, the data suggest that granulocyte sticking and emigration could account for a consumption of granulocytes that on an acute basis could deplete the body stores, which could explain the apparent decrease in total body granulocytes seen clinically following major thermal trauma.

Animals↗
PubMed1979

Dissolution of cobalt from hard metal alloys by cutting fluids.

On grinding hard metal alloys containing cobalt, the dissolution of cobalt during 5 days was studied for nine commercial cutting fluids. After 1 day, a major part of the cobalt liberated from the material ground is found in solution. This percentage decreases when grinding is continued using the same coolant fluid. Only a small fraction of the cobalt is found in particles in the circulating fluid. The bulk must be in the sediment in the storage tank, where it does no harm to the workers' skin. The final concentration of cobalt found in some fluids may be hazardous.

Air Pollutants, Occupational↗
PubMed1979

Problems in recording arthroscopy.

Several good combinations of photographic equipment are available today for recording arthroscopies. Some of them are so simple to use that everyone can obtain good still pictures through the arthroscope. It is usually preferable to enlarge the arthroscopic pictures in order to get better slides for presentations during lectures and at scientific meetings. Movie film and video tape offer a more dynamic recording but are both fairly expensive. The use of video tape can cause problems during presentations to larger audiences. Video tape, however, can be transferred to 16 mm. movie film, which is the international standard in the teaching world. Color TV has three different standards in different parts of the world and there are at least four different video casette systems available today.

Documentation↗
PubMed1979

Ender nailing in fractures of the diaphysis of the femur.

Sixteen fractures of the diaphysis of the femur were nailed according to the Ender technique. Fifteen of these were of types for which Küntscher nailing was contraindicated. In five of the injuries a comminuted fracture of the femoral shaft was present, associated with a fracture of the proximal end of the femur. Most of the nailings were done closed. The time of surgery was short and the blood loss, small. All of the fractures healed and no major postoperative problems were noted.

Adolescent↗
PubMed1979

Immunization aginast tetanus with aluminium free-versus aluminium contain triple vaccine.

In order to discover if elimination of aluminium from the very effective triple vaccine gives an unsatisfactory immunity against tetanus, the following investigation has been performed. 47 children were immunized in 1968 and 1969 during the first year of life with 3 injections of aluminium free triple vaccine given with an interval of 4--6 weeks. The vaccine contained 10 Lf tetanus toxoid per dose. 8 years later, during 1976 and 1977, they were given boosters containing aluminium adsorbed Td with 4 Lf tetanus toxoid. The above mentioned group was compared with 29 children immunized in the 1950's in the same way but with aluminium adsorbed triple vaccine (13--19 Lf tetanus toxoid per dose). The booster with DT given 6 to 7 years later contained 8 Lf aluminium adsorbed tetanus toxoid. The serum content of tetanus antitoxin was determined before and after the booster. The result showed that the tetanus immunity was very satisfactory even though the basic immunization was performed with aluminium free triple vaccine.

Aluminum↗
PubMed1978

Prevention of dermal ischemia after thermal injury.

One percent methylprednisolone acetate was evaluated as a pharmacologic agent in the prevention of dermal ischemia following burning. Standardized partial thickness burns were inflicted on guinea pigs. Burned guinea pigs were separated into five groups; one was treated with topical steroid, one with systemic steroid, one with both, one with emollient base without steroid, and one served as an untreated control. Histology and depth of dermal ischemia were evaluated by india ink perfusion technique. Untreated controls showed progressive dermal ischemia with complete absence of india ink-filled vessels in the dermis by 24 hours. Topical steroid alone improved dermal perfusion as suggested by relative levels of india ink filling. Topical steroid in the dosage used does not potentiate infection in standard burn wound sepsis models. Preservation of dermal appendages was seen secondary to improved dermal microcirculation with a ninefold increase in hair follicles in treated guinea pigs compared with controls.

Administration, Topical↗
PubMed1978

Experimental flap delay with formic acid.

Using dorsal, cranially based 10 X 3 cm composite pedicle flaps in rats, the effects of an injection of 2 ml of formic acid in different concentrations was studied. Concentrations of 0.2 per cent gave a very significant increase in flap survival over controls. Preoperative penicillin did not influence the outcome.

Animals↗
PubMed1977

Hepatitis B immune globulin in prevention of hepatitis B among hospital staff members.

In a double-blind trial of hospital staff members at risk of contracting hepatitis B, 110 subjects received hepatitis B immune globulin or immune serum globulin prophylactically. An additional 125 individuals working in the same locations were unwilling to participate in the trial and received no prophylaxis. During the study period of 28 months, 13 cases of clinical hepatitis B occurred in the untreated group, whereas only three cases occurred among the subjects who received prophylaxis.

Adult↗
PubMed1977

Microvascular effects of a topically applied cationic triphenylmethane dye (crystal violet).

The effects of local application of crystal violet on the microcirculatory system are reported. The testing system consisted of vital microscopy of the cheek pouch of the hamster and microangiography of rabbit's ear. It appeared that the early microcirculatory disturbances caused by a dilute aqueous solution of crystal violet were transient, whereas considerable tissue toxicity was shown in the long-term experimental model. A direct cytotoxic effect is suggested.

Angiography↗
PubMed1976

Active immunization against tetanus in man. II. Combined active and passive prophylaxis with human tetanus immune globulin.

19 Persons were actively immunized with adsorbed tetanus toxoid and were simultaneously given tetanus immune globulin of human origin, TIG(H), in doses of 500-1500 IU. Their antitoxin titres were followed for 1 year. Seven persons were given only TIG(H), 500 IU and 1500 IU and their antitoxin titres were followed for 3 months to 1 year. For comparison, 30 military recruits were actively immunized with adsorbed tetanus toxiod according to common practice. Their antitoxin titres were followed for 1 year. The response to complete active immunization could not be demonstrated to be impaired by passive immunization, when 500 IU or 1500 IU OF TIG(H) were given simultaneously with toxoid. The titres were in accordance with those achieved by active immunization of the recruits.

Adult↗
PubMed1975

Hepatitis B immune serum globulin in prevention of hepatitis B among hospital personnel. Preliminary report from a controlled trial.

At Sahlgren Hospital, Göteborg, hepatitis B has been a serious problem for several years among the personnel in the hemodialysis and renal transplantation wards as well as in the chemical laboratories. For this reason a randomized controlled clinical study with conventional gammaglobulin and hepatitis B immune globulin was started in May 1973. The titer of anitbodies against HBsAg by passive hemagglutination was 1:100 and approximately 1:350,000, respectively. Newly employed staff without a history of jaundice and without demonstratable HBsAg (RIA) or HBsAb (RIP) in serum were enrolled in the trial. Assignment of the two preparations was performed by random numbers and the ampoules were labelled only with the serial number of the participant. Three cc of either preparation was administered i.m. within seven days after admission and was repeated three months later. After that no further injections were given. Each participating employee was followed up with liver function tests, IEOP, RIA and RIP tests for at least six months after the last injection. Preliminary results from this double-blind study, which is still going on, are presented.

Clinical Trials as Topic↗
PubMedDate not supplied

Hepatitis B immune serum globulin and standard gamma globulin in prevention of hepatitis B infection among hospital staff: a preliminary report.

In May 1973 a controlled double-blind clinical trail with prophylactic injects of hepatitis B immune serum globulin (antibody titer by passive hemagglutination 1:355,000) and standard gamma globulin (1:100) was started in Sahlgren's Hospital, Göteborg, Sweden. The annual attack rate of clinical hepatitis B in the three departments studied had been 5 to 8 per cent during recent years. A total of 118 members of the hospital staff were prophylactically treated while 125 staff members were unwilling to participate and received no prophylactic treatment. During the first 20 months of study nine cases of clinical hepatitis B with jaundice occurred within the untreated group (7.2 per cent) while three cases (2.5 per cent) were observed in prophylactically treated individuals. After decoding it was found that 60 individuals had received specific hepatitis B immune serum globulin while 58 had received standard gamma globulin. Two of the three clinical cases of hepatitis B occurred within the standard gamma globulin group. Both groups included two individuals with transient antigenemia only and the standard gamma globulin group also included four individuals with antibody seroconversion.

Antibody Formation↗