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Biomedical subjects

E Esser

Publications and source records attributed to E Esser.

At least 55 records · Page 3Linked to original sources
PubMed1975

[First clinical results of radiotherapy following partial synchronization by bleomycin].

On the Ehrlich-ascites tumor and on the solide Ehrlich carcinoma of the mouse, bleomycin causes a large fixation in the (G2+M)-phase of the cell cycle of the tumor cells. Even in certain human solide tumors, after the application of bleomycin in a predetermined period an increase of the G2 portion of the proliferating cells can be observed. By individual control which can be peraformed rapidly and with high accuracy by impulse cytophotometry, this partial synchronisation effect can be used for radiotherapy.

Animals↗
PubMed1975

[Radiotherapy of inoperable orofacial squamous epithelial carcinomas following pharmacologically induced partial synchronization].

A therapeutical method of inoperable squamous cell carcinomas based on cell kinetics has been applied since 1969 by using 5-fluorine-uracil. Impulse cytophotometric tests did not confirm the degree of partial synchronization due to 5FU that had been assumed so far on the basis of autoradiographic techniques. The results obtained in 46 patients with inoperable malignant epithelial tumors of the maxillo-facial region that were better than those obtained with radiological therapy only, can to a certain extent be contributed to 5FU. First impulse cytophotometric findings in biopsies of animal and human tumors show that Bleomycin clearly produced partial synchronization due to a reversible stop in the radiation-sensitive G2 phase.

Aged↗
PubMedDate not supplied

Modified neoadjuvant therapy regime with low dose irradiation in advanced head and neck cancer patients: preliminary results of a pilot study to minimize side effects.

We analysed the files of 52 patients with advanced head and neck tumors who were treated in a pilot phase. The therapy consisted of two courses of induction chemotherapy with ifosfamide and cisplatin followed by hyperfractionated-accelerated radiotherapy with a total dose of only 30 Gy. Surgery was performed within the following 7 days with tumor resection and neck dissection. Histologically we found in 50% of the specimens total necrosis of the tumor. The median survival time is calculated to be 22 months. The median follow-up time thus far is 36 months. Hence, therapy results are comparable to other therapy schedules. But side effects, especially late side effects had become minor. Therefore, our therapy regime results in augmentation of the quality of life of these patients.

Adult↗
PubMedDate not supplied

Diagnosis of bronchial carcinoma on sections of paraffin-embedded sputum. Sensitivity and specificity of an alternative to routine cytology.

The diagnostic accuracy of sputum cytology for the diagnosis of bronchial carcinoma using paraffin-embedded, serially sectioned and hematoxylin and eosin-stained specimens was tested in 4,297 sputum samples from 1,889 patients, 219 of whom had bronchial carcinoma. The diagnostic sensitivity depended mainly on the number of investigated samples and was 85.4% with three sufficient sputa. The sensitivity was not influenced by the histologic types, location or TNM stage of the tumor. The specificity of the method was 99.5%. In three cases localization of sputum cytologically diagnosed bronchial carcinomas was not possible immediately (occult carcinomas, pTx); in two of these cases the bronchial carcinomas were located during follow-up. The third patient died without verification of the cytologic diagnosis. According to our results, sputum cytology on serial sections is a valuable instrument for mass screening of high-risk groups for the early detection of bronchial carcinoma. Lower sensitivities of sputum cytology in mass screening programs for the early diagnosis of lung cancer are discussed critically.

Carcinoma, Bronchogenic↗